Potentiation of tissue culture rabies vaccine by adjuvants.

Fenje, P; Pinteric, L.

doi:10.2105/ajph.56.12.2106

Cited by 17 publications

(7 citation statements)

References 19 publications

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“…Additional study is needed to develop further the described method so as to allow the determina-VOL. 6,1972 485 on August 1, 2020 by guest http://iai.asm.org/ Downloaded from tion of the degree of protection against rabies in a single serum sample. This seems to be possible by the application of a comparative assay in which an unabsorbed part of the serum is tested against another portion, absorbed with viral antigen.…”

Section: Resultsmentioning

confidence: 99%

Antibody and Immunoglobulin Response to Antirabies Vaccination in Man

1972

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Serum neutralization antibody and immunoglobulin responses in 30 individuals were studied in paired serum samples which had been obtained before and 2 to 3 weeks after the administration of a recall dose of rabies tissue culture vaccine. The immune reaction consisted of a predominantly immunoglobulin G (IgG) antibody response. Also, a significant increase in neutralizing antibody titers was observed, but without a consistently correlated change of the IgG levels in the individual serum samples. The radial immunodiffusion test appears to contain the elements necessary for the development of a routine test to determine rabies antibody in single serum samples.

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Section: Resultsmentioning

confidence: 99%

Antibody and Immunoglobulin Response to Antirabies Vaccination in Man

1972

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“…(i) The CVS strain of fixed rabies virus, diluted to contain 100 to 200 mouse LD50 per 0.03 ml, was mixed with equal amounts of either interferon pool B or with serum from uninoculated rabbits (control). After incubation of these sets at 37 C for 1.5 hr, the standard mouse test for the determination of rabies virus-neutralizing antibodies was performed as in a previous study (7). No neutralizing activity to CVS was detected in either rabbit serum.…”

Section: Resultsmentioning

confidence: 99%

“…MATERIALS AND METHODS The rabies street virus originated from a naturally infected fox (7). The virus suspension was stored as a 10% homogenate of the salivary gland and contained 8,000rabbit intramuscular (im) LD5o per 0.4 ml.…”

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confidence: 99%

Effect of Administered Interferon on Rabies in Rabbits

Postic¹,

Fenje²

1971

Applied Microbiology

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This study describes the effect of interferon on the survival of rabbits infected with a street strain of rabies virus. Interferon was prepared by collecting serum from rabbits injected with Newcastle disease virus and was characterized by biological and physicochemical methods. Rabbit serum interferon mixed and incubated with a suspension of rabies virus did not neutralize its infectivity. Rabbits were inoculated into the hind leg muscle with approximately 80 LD50 of virus. Interferon was administered intravenously or intramuscularly, or by both methods, in the same or opposite leg as virus. Mortality due to rabies was significantly reduced by the concurrent administration of 8 x 105 units of interferon divided between the site of virus inoculation and intravenously. There was less protection if 3 hr elapsed between the inoculation of virus and interferon. Treatment given 24 hr after infection did not prevent death but prolonged the incubation period.

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“…The Street-Alabama-Dufferin (SAD) strain, which was developed using hamster kidney cells, has been used to produce MLV vaccines [8,9]. Although modified live rabies vaccine strains (ERA, Flury, and SAD) are safe and potent in dogs, the WHO stopped recommending MLV rabies vaccines for parenteral inoculation in animals in 2004.…”

Section: Current Rabies Vaccinesmentioning

confidence: 99%

The present and future of rabies vaccine in animals

Yang

Kim

Lee

et al. 2013

Clin Exp Vaccine Res

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An effective strategy for preventing rabies consists of controlling rabies in the host reservoir with vaccination. Rabies vaccine has proven to be the most effective weapon for coping with this fatal viral zoonotic disease of warm-blooded animals, including human. Natural rabies infection of an individual is always associated with exposure to rabid animals, and the duration of clinical signs can vary from days to months. The incubation period for the disease depends on the site of the bite, severity of injury, and the amount of infecting virus at the time of exposure. The mortality of untreated cases in humans is 100%. Over the last 100 years, various rabies vaccines have been developed and used to prevent or control rabies in animals, such as modified live vaccine, inactivated rabies vaccine, and oral modified live vaccine. These have proved safe and efficacious worldwide. New-generation rabies vaccines, including recombinant rabies virus-based vaccines, vectored vaccines, DNA-based vaccines, and plant vaccines, have been explored to overcome the limitations of conventional rabies vaccines. This article discusses current and next-generation rabies vaccines in animals.

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Potentiation of tissue culture rabies vaccine by adjuvants.

Cited by 17 publications

References 19 publications

Antibody and Immunoglobulin Response to Antirabies Vaccination in Man

Antibody and Immunoglobulin Response to Antirabies Vaccination in Man

Effect of Administered Interferon on Rabies in Rabbits

The present and future of rabies vaccine in animals

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