Potentiation of the immobility response elicited by bandaging and clamping in mesencephalic rats

Cruz, Fidel de la; Urióstegui, T.; Zamudio, Sergio; Pacheco, Jorge; Garcia, M. C.; Quevedo, Lucı́a; Chuc, Eliezer

doi:10.1016/0031-9384(95)00123-z

Cited by 9 publications

(3 citation statements)

References 22 publications

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“…Many experiments have produced immobility responses by damaging certain regions of the brain that control postural reflexes and locomotion, such as the lateral hypothalamus [6]. As well, mesencephalic lesioned rats have also been tested and shown an increase in different ways of immobility [7]. The so-called catatonia of schizophrenics is related to some hyperactivity in the dopaminergic system, since it is highly susceptible to neuroleptic drug treatment.…”

Section: Introductionmentioning

confidence: 99%

Differential Effect on Two Immobility Responses by Chronic Administration of 1,3-di-o-Tolyl-Guanidine (Sigma Receptor Agonist) in Rats with Neonatal Ventral Hippocampal Lesion

Jaramillo¹,

Cruz²,

Vargas³

et al. 2014

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The effect of chronic administration of the sigma agonist: 1,3-di-o-tolyl-guanidine (DTG), in neonatal ventral hippocampal lesioned (nVHL) rats, on the immobility by clamping and dorsal immobility, were investigated. The nVHL increases the duration of immobility by clamping, but does not affect the duration of the dorsal immobility. We found that DTG augments the duration of the dorsal immobility in the unlesioned rats, but does not modify the duration of immobility induced by clamping the neck. DTG also counteracts the increase in the duration of the immobility by clamping produced by nVHL. However, the increase in the duration of the dorsal immobility produced by DTG is counteracted by nVHL. These results are discussed with respect to the differential effect on the two immobility responses tested, suggesting that they are different forms of immobility mediated by different mechanisms although they behaviorally share common characteristics.

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Section: Introductionmentioning

confidence: 99%

Differential Effect on Two Immobility Responses by Chronic Administration of 1,3-di-o-Tolyl-Guanidine (Sigma Receptor Agonist) in Rats with Neonatal Ventral Hippocampal Lesion

Jaramillo¹,

Cruz²,

Vargas³

et al. 2014

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“…Old, neonatal and mesencephalic rats respond in a similar way to more diverse stimuli, involving either clamping or bandaging [48]. Therefore, the evidence seems to provide some basis for formulating the hypothesis that the neocortex could be "weakened" in old rats by the administration of potassium, at least for some IRs (clamping and bandaging).…”

Section: Discussionmentioning

confidence: 84%

“…Several lines of evidence indicate that the neocortex is involved in inhibiting the IR response: 1) this susceptibility decreases in the young animals at the time when the neocortex matures [45]; 2) the surgical decortication of unsusceptible animals can make them susceptible [45]; 3) KCl-induced spreading depression of the neocortex also potentiates the IR [46] [47]; and 4) mesencephalic rats are more susceptible to IR than intact adult rats [48]. The mesencephalic rats are similar to neonatal rats, but have more diverse stimuli, either clamping or bandaging are capable of inducing IR.…”

Section: Discussionmentioning

confidence: 99%

Immobility Responses Affected by Potassium in Old Rats

Garcés‐Ramírez¹,

Morales-Dionisio²,

Flores³

et al. 2020

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Four immobility responses (IR): elicited by clamping, bandaging, grasping and inversion, and their modification by potassium and spironolactone was studied in old Wistar rats (body weight, 500 g). When undrugged, only clamping and grasping, but not bandaging and inversion induced an IR in rats. Potassium and spironolactone significantly enhanced the duration of IR induced by clamping but not by grasping. They also induced an immobility response by bandaging, but not by inversion. The data suggest that IR induced by clamping and bandaging are somehow related to changes in the potassium serum levels. Consequently, such a relationship may be a suitable model to study some forms of paralysis in human beings which are related to changes in the potassium serum levels.

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Inhibition of midbrain-evoked tonic and rhythmic motor activity by cutaneous stimulation in decerebrate cats

2003

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The effect of mechanical and electrical stimulation of cervical cutaneous afferents was analysed on both the centrally induced tonic and rhythmic activities in hindlimb antagonist muscle nerves of 16 decerebrate paralysed cats. Electrical stimulation of dorsal midbrain evoked in the nerve to the tibialis anterior muscle (TAn) either rhythmic discharges (n=14), associated with tonic discharges in ten cats, or only tonic discharges (n=4). Centrally induced activity in the ipsilateral nerve to gastrocnemius medialis (GMn) occurred in fewer cats (n=12) and displayed similar patterns as in TAn. Manual traction of the scruff of the neck reduced the TAn tonic and rhythmic discharges (n=6) by 73% (P<0.05) and 71% (P<0.05), respectively, and reduced only the tonic component of GMn discharges (by 41%, n=3). Electrical stimulation (impulses 0.1-0.5 ms, 50 Hz) of cervical nerves belonging to C5 or C6 dermatomes, the intensity (0.4-4 mA) of which induced minimal inhibition of both TAn and GMn discharges, reduced significantly the tonic component of TAn discharges (by 39%, n=4). At higher intensities of electrical cervical nerve stimulation (2-6 mA) inducing maximal inhibitory effect, both tonic and rhythmic activities in TAn and GMn were both significantly reduced by, respectively, 81% and 94% in TAn (n=7), and by 49% and 43% in GMn (n=7). Electrical cervical nerve stimulation consistently reduced the isolated tonic discharge in TAn by 66% (n=4, P<0.05) and in GMn by 23% (n=3) when present. Thus the tonic component was more sensitive to inhibition than the rhythmic component of hindlimb muscle nerve activity.

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Potentiation of the immobility response elicited by bandaging and clamping in mesencephalic rats

Cited by 9 publications

References 22 publications

Differential Effect on Two Immobility Responses by Chronic Administration of 1,3-di-o-Tolyl-Guanidine (Sigma Receptor Agonist) in Rats with Neonatal Ventral Hippocampal Lesion

Differential Effect on Two Immobility Responses by Chronic Administration of 1,3-di-o-Tolyl-Guanidine (Sigma Receptor Agonist) in Rats with Neonatal Ventral Hippocampal Lesion

Immobility Responses Affected by Potassium in Old Rats

Inhibition of midbrain-evoked tonic and rhythmic motor activity by cutaneous stimulation in decerebrate cats

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