Potentiation of Renoprival Hypertension by Alanine, Pyruvate and Lactate

Ee, Muirhead; Jones, Frances E.; Ja, Stirman

doi:10.1152/ajplegacy.1957.191.3.537

Cited by 3 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 8 dogs the whole kidney was explanted to the peritoneum under sodium pentobarbital anesthesia as follows. 1) The left kidney was removed through an anterior midline abdominal incision.…”

Section: Explantation Proceduresmentioning

confidence: 99%

“…The diet and saline were given once daily. The general design of the experiment was the same as that used previously (7,8). After the second nephrectomy, the mean arterial pressure was obtained twice daily about 5 to 6 hours apart for 4 days.…”

Section: Explantation Proceduresmentioning

confidence: 99%

“…The hemolytic state may be identified by a shortening of the survival of the erythrocytes in vivo (5). The hypertension of bilateral nephrectomy has been shown to be aggravated by sodium (6), sodium and dietary protein (7), and sodium plus alanine, lactate or pyruvate (8). The evaluation of this type of hypertension, as observed in the dog, has been standardized in our laboratory by giving the animal a prescribed amount of protein by diet and of sodium by vein (7).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Renal Autoexplantation and Protection Against Renoprival Hypertensive Cardiovascular Disease and Hemolysis *

Muirhead¹,

Stirman²,

Jones³

1960

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

“…In 8 dogs the whole kidney was explanted to the peritoneum under sodium pentobarbital anesthesia as follows. 1) The left kidney was removed through an anterior midline abdominal incision.…”

Section: Explantation Proceduresmentioning

confidence: 99%

Section: Explantation Proceduresmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Renal Autoexplantation and Protection Against Renoprival Hypertensive Cardiovascular Disease and Hemolysis *

Muirhead¹,

Stirman²,

Jones³

1960

J. Clin. Invest.

Self Cite

View full text Add to dashboard Cite

“…In studies on renoprival hypertension, Muirhead et al (247) have shown that the eleva tion of pressure can be potentiated by addition to the diet of excessive pro tein, alanine, pyruvate, or lactate. GroUman (248) has been able to produce renal hypertension in both rats and dogs by either potassium or choline deficiency, and these effects can be further accentuated by substituting 1 per cent sodium chloride for the animal's drinking water or by administering alcohol.…”

Section: Abnormalities Of the Peripheral Circulationmentioning

confidence: 99%

Peripheral Circulation

Guyton¹

1959

Annu. Rev. Physiol.

View full text Add to dashboard Cite

During the two years since Peterson's review of the peripheral circulation in the Annual Review of Physiology (1), such a tremendous volume of litera ture on this subject has appeared that the references reviewed in the present paper have had to be selected with extreme care. Also, because the pharma cological aspects of the peripheral circulation were reviewed in the Annual Review of Physiology by Bovet & Carpi in 1957 (2), only those aspects of the pharmacology of the peripheral circulation that shed light on physiological mechanisms will be covered. This paper presents, first, the general dynamics of the peripheral circulation and then studies relating to certain peripheral circulatory diseases and regional vascular beds. BLOOD VOLUMEMeasurements.-The methods for measuring blood volume have been reviewed by Mertz (3). Especially interesting in the past two years has been the development of far more knowledge concerning the vascular-extravascu lar interchange of fluids and proteins (4 to 12), the lack of which has long been one of the major deterrents to accurate measurements of blood volume. Studies, particularly by Mayerson et al. (4, 5) and Huggins et al. (7 to 11), have shown that transfusion of large excesses of blood or other fluids into the circulation can sometimes so overstretch the capillaries that a "stretched pore phenomenon" (5) occurs, allowing excessive leakage not only of fluid into the extravascular spaces but also of large portions of the plasma pro tein. Becapse of this effect the usual dilution techniques for measuring blood volume become very inaccurate. However, by using radioactive protein, then allowing the plasma proteins to come to equilibrium with the extra vascular proteins, and finally mathematically accounting for the extra vascular portion of the proteins, it is possible to determine plasma volumes with reasonable accuracy even when proteins leak from the circulation very rapidly (4, 6). Regulation of blood volume.-Sjostrand (13), in reviewing the regulation of blood volume, points out that the basic regulatory factor is the capacity of the vascular system itself. The next factor of importance is the shift of fluids through the capillary membrane between the extravascular and vascu lar spaces. Following transfusion into a normal animal, fluid loss into the tissues begins immediately and continues until the blood volume is read justed to a normal value; and, conversely, following hemorrhage the dynam ics of capillary equilibrium cause an immediate onset of fluid transfer into 1 The survey of the literature pertaining to this review was concluded May 1,1958. 239 Annu. Rev. Physiol. 1959.21:239-270. Downloaded from www.annualreviews.org Access provided by University of California -San Francisco UCSF on 02/02/15. For personal use only. Quick links to online content Further ANNUAL REVIEWS

show abstract

Metabolites and Hypertension: Insights into Hypertension as a Metabolic Disorder

et al. 2020

View full text Add to dashboard Cite

For over 100 years, essential hypertension has been researched from different perspectives ranging from genetics, physiology, and immunology to more recent ones encompassing microbiology (microbiota) as a previously underappreciated field of study contributing to the cause of hypertension. Each field of study in isolation has uniquely contributed to a variety of underlying mechanisms of blood pressure regulation. Even so, clinical management of essential hypertension has remained somewhat static. We, therefore, asked if there are any converging lines of evidence from these individual fields that could be amenable for a better clinical prognosis. Accordingly, here we present converging evidence which support the view that metabolic dysfunction underlies essential hypertension.

show abstract

Potentiation of Renoprival Hypertension by Alanine, Pyruvate and Lactate

Cited by 3 publications

References 0 publications

Renal Autoexplantation and Protection Against Renoprival Hypertensive Cardiovascular Disease and Hemolysis *

Renal Autoexplantation and Protection Against Renoprival Hypertensive Cardiovascular Disease and Hemolysis *

Peripheral Circulation

Metabolites and Hypertension: Insights into Hypertension as a Metabolic Disorder

Contact Info

Product

Resources

About