Potentiation of Growth Hormone Activity in Sheep Using McNcclcnal Antibodies

Pell, J. M.; Johnsson, I. D.; Pullar, R.A.; Morrell, David J.; Hart, I. C.; Holder, A. T.; Aston, R.

doi:10.1677/joe.0.120r015

Cited by 38 publications

(15 citation statements)

References 12 publications

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“…[8][9][10][11][12][13] Here, we show that antibody buffering can occur in a different body compartment, the CSF. Using a small molecule ligand, 2-phenyl-oxazol-5-one-methylene-γ-amino butyrate, we demonstrate that antibody buffering can extend the pharmacokinetic profile of a drug in the rat cerebrospinal fluid.…”

Section: Introductionmentioning

confidence: 99%

Antibody Buffering in the Brain

O’Hear

Foote²

2006

Journal of Molecular Biology

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Section: Introductionmentioning

confidence: 99%

Antibody Buffering in the Brain

O’Hear

Foote²

2006

Journal of Molecular Biology

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“…An enhancing effect on gonadotropin activity was described in vivo in Snell dwarf mice using the uterine weight bioassay, with polyclonal Abs directed against the β-subunit of ovine FSH [95] and monoclonal Abs directed against bovine FSH [96]. Likewise, anti-GH [97] and anti-TSH [98] monoclonal Abs exhibiting enhanced bioactivity both in vitro and in vivo when complexed with their cognate hormone have been described [99,100]. More recently, Boyman et al have demonstrated the enhancing effect of IL/anti-IL Ab complexes (IL-2 and IL-7) in cancer treatment [101,102].…”

Section: Enhancing Antibodies Complexed With Gonadotropins As Biased mentioning

confidence: 99%

Novel pathways in gonadotropin receptor signaling and biased agonism

Ulloa‐Aguirre

Crépieux

Poupon

et al. 2011

Rev Endocr Metab Disord

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Gonadotropins play a central role in the control of male and female reproduction. Selective agonists and antagonists of gonadotropin receptors would be of great interest for the treatment of infertility or as non steroidal contraceptive. However, to date, only native hormones are being used in assisted reproduction technologies as there is no pharmacological agent available to manipulate gonadotropin receptors. Over the last decade, there has been a growing perception of the complexity associated with gonadotropin receptors' cellular signaling. It is now clear that the Gs/cAMP/PKA pathway is not the sole mechanism that must be taken into account in order to understand these hormones' biological actions. In parallel, consistent with the emerging paradigm of biased agonism, several examples of ligand-mediated selective signaling pathway activation by gonadotropin receptors have been reported. Small molecule ligands, modulating antibodies interacting with the hormones and glycosylation variants of the native glycoproteins have all demonstrated their potential to trigger such selective signaling. Altogether, the available data and emerging concepts give rise to intriguing opportunities towards a more efficient control of reproductive function and associated disorders.

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“…Indeed, peripherally administered therapeutic antibodies against amyloid ␤-peptide are found in the central nervous system (8) and enhancing antibodies to porcine growth hormone (GH) change the distribution of tissue GH (107,114). An intriguing observation in antibody enhancement of peptide hormone activity is that only a proportion of exogenous hormone needs be complexed to antibody for potentiation to occur (51,88).…”

Section: Identifying Important Parameters Of Antibody Interactions Inmentioning

confidence: 99%

Antibodies as molecular mimics of biomolecules: roles in understanding physiological functions and mechanisms

Hill

Flint

Pell

2008

Advances in Physiology Education

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Physiologists have routinely used understanding of the immune system to generate antibodies against regulatory molecules, growth factors, plasma membrane receptors, and other mammalian molecules in the development of analytical tools and assays. In taking this notion further, antibodies have been used in vivo to modulate physiological systems and to improve our understanding of their molecular interactions. To develop antibodies with physiological activity (efficacy), physiologists have worked with immunologists in developing interdisciplinary insights, requiring basic knowledge of immune system function in designing strategies to generate antibodies that interact with endogenous molecules of physiological interest, in vivo. Antibodies in different physiological systems have been shown to enhance or inhibit endogenous molecular functions. Two approaches have been used: passive and active immunization. Antibodies in these contexts have provided tools to develop further insights into molecular physiological mechanisms. Perhaps surprisingly, enhancing antibodies have been developed against a diverse set of target molecules including several members of the growth hormone/insulin-like growth factor-I axes and those of the beta(2)-adrenoceptor axis. Antibodies that inhibit the actions of somatostatin have also been developed. A further novel approach has been the development of antibodies that interact with adipose cells in vivo. These have the potential to be used in therapeutic antiobesity approaches. Antibodies with efficacy in vivo have provided new insights into molecular physiological mechanisms, enhancing our understanding of these complex processes.

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Potentiation of Growth Hormone Activity in Sheep Using McNcclcnal Antibodies

Cited by 38 publications

References 12 publications

Antibody Buffering in the Brain

Antibody Buffering in the Brain

Novel pathways in gonadotropin receptor signaling and biased agonism

Antibodies as molecular mimics of biomolecules: roles in understanding physiological functions and mechanisms

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