Potentiation of Brain Bioavailability Using Thermoreversible Cubosomal Formulation
Harshvardhan Jain,
Bala Prabhakar,
Pravin K. Shende
Abstract:The aim of the present study was to develop and evaluate intranasal formulations of the thermoreversible fluoxetine cubosomal in situ gel. This gel was intended for permeation and bioavailability enhancement to target the brain effectively by bypassing the blood−brain barrier (BBB). Fluoxetine-loaded cubosomes were prepared by the homogenization method followed by the cold method approach to develop in situ gel. Fluoxetineloaded cubosomes displayed a higher encapsulation efficiency (82.60 ± 1.25%) than fluoxet… Show more
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