Potentiation of antifungal activity of terbinafine by dihydrojasmone and terpinolene against dermatophytes

Pinto, Ânderson de Vasconcelos; Oliveira, Josenildo Cândido de; Medeiros, César Augusto Costa de; Silva, Shellygton Lima; Pereira, Fillipe de Oliveira

doi:10.1111/lam.13371

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…The high correlation of α-Phellandrene, Eucalyptol, Terpinolene and α-Terpineol with the inhibition effect was also demonstrated in previous findings. [49][50][51][52][53] Using the rule of variation between constituent difference and biological activity, the EO compounds could be applied in the targeted inhibition of different kinds of strains. addition, according to the antioxidant effect and gray correlation analysis, the content of rosemary EO in the compounded EOs was positively correlated with the antioxidant effect, and its good antioxidant effect was attributed to the high content of β-Pinene.…”

Section: Discussionmentioning

confidence: 99%

Contribution of Constituents in Rosemary‐Magnolia Compound Essential Oil to Antibacterial, Antioxidant and Cytotoxicity Bioactivities Revealed by Grey Correlation Analysis

Song

Zhang

Jin³

et al. 2023

Chemistry & Biodiversity

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The compound of essential oils (EOs) is a key approach to achieving the superimposed efficacy of plant EOs. In this article, grey correlation analysis was applied for the first time to explore the compound ratios and contribution between constituents and the bioactivity of the compound EOs. There were 12 active constituents shared in rosemary and magnolia EOs prepared by negative pressure distillation. With different proportions, these two EOs were blended and analyzed for the antioxidant, bacteriostatic and antitumor effects. According to the results of the inhibition circle, minimum bactericidal and inhibitory concentration, the most obvious inhibition effect of the compound EOs on different strains of bacteria was shown in Staphylococcus aureus. The results of antioxidant test showed that single EO from rosemary had the best antioxidant effect, and its EO content was directly proportional to the antioxidant effect. The cytotoxicity results showed that, there was a significant difference in the lethality of the compound EOs between tumor cells Mcf-7 (human breast cancer cells) and SGC-7901 cells (human gastric cancer cells). Furthermore, single EO from magnolia had an obvious inhibitory effect on the growth of Mcf-7 cells and SGC-7901 cells, and the cell lethality rate was as high as 95.19 % and 97.96 %, respectively. As the results of grey correlation analysis, the constituents with the maximal correlation of inhibitory effects on bacteria were as follows: S. aureus -Terpinolene (0.893), E. coli -Eucalyptol (0.901), B. subtilis -α-Pinene (0.823), B. cereus -Terpinolene (0.913) and Salmonella -α-Phellandrene (0.855). For the ABTS and DPPH scavenging effects, the constituents with the maximal correlation were (À )-Camphor (0.860) and β-Pinene (0.780), respectively. In terms of the effects of the active constituents of compound EOs on the inhibitory activities of tumor cells Mcf-7 and SGC-7901, the three active constituents of γ-Terpinene, (R)-(+)-β-Citronellol and (À )-Camphor were in the top three, and their correlation were Mcf-7 (0.833, 0.820, 0.795) and SGC-7901 (0.797, 0.766, 0.740). Our study determined the contribution degree of active constituents in the antibacterial, antioxidant, and antitumor bioactivities of rosemarymagnolia compound EOs, and also provided new insights for the research of EOs combination formulations.

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Section: Discussionmentioning

confidence: 99%

Contribution of Constituents in Rosemary‐Magnolia Compound Essential Oil to Antibacterial, Antioxidant and Cytotoxicity Bioactivities Revealed by Grey Correlation Analysis

Song

Zhang

Jin³

et al. 2023

Chemistry & Biodiversity

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“…Camphor can downregulate genes related to biofilm formation, thus reducing the virulence of C. albicans [73]. Terpinolene works by disrupting C. albicans membrane integrity [74]. Another bioactive compound from C. xantorrhiza is xanthorhizzol, a bisabolane-type sesquiterpenoid that can disrupt C. albicans cell membrane [75].…”

Section: Discussionmentioning

confidence: 99%

Tropical Medicinal Plant Extracts from Indonesia as Antifungal Agents against Candida Albicans

Geraldi¹,

Wardana²,

Aminah³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: Candida albicans is responsible for a wide range of medical ailments, from harmless cutaneous to life-threatening bloodstream infections. Growing cases of antifungal-drug resistance strains of C. albicans become a rationale to explore and develop novel anti-candida agents. In this paper, we assessed the anti-candida activity of the methanolic extracts of various tropical medicinal plants from Myrtaceae, Poaceae, and Zingiberaceae, commonly used in Indonesia to treat fungal infections. Methods: Candida albicans strain ATCC 10231 was used as a subject to assess the anti-Candida activities of plant methanolic extracts through disc diffusion assay. Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC) were observed. Results: All plant extracts in this study showed antifungal activities against C. albicans. Among them, Cymbopogon citratus, Curcuma xanthorrhiza, Curcuma aeruginosa, and Zingiber officinale var. rubrum showed the lowest MIC and MFC value of 3.8 mg/mL. Conclusions: The growth inhibition of C. albicans on disc diffusion assay was demonstrated by Z. officinale var. rubrum and C. longa, which were comparable to antifungal nystatin. Further investigation of the chemical constituents of the extracts and the cytotoxicity test is needed to further develop plant-derived anti-candida agents.

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“…antinociceptive [38][39][40], neuroprotective [41][42][43][44], sedative/motor relaxant [45][46][47], and antifungal [48,49] properties. This broad range of metabolites in different concentrations provides unique therapeutic applications for full spectrum extracts.…”

Section: Biosynthesis Of Phytocannabinoidsmentioning

confidence: 99%

“…They are mainly responsible for the odor and taste present in cannabis flowers and are used in perfume fragrances and cleaning products worldwide. Besides these organoleptic characteristics, terpenes/terpenoids have been studied for their therapeutic potential, with works analyzing analgesic [19][20][21], anti-inflammatory [22][23][24][25][26], gastroprotective [27][28][29], anxiolytic/antidepressant [30][31][32][33][34][35], apoptotic/antimetastatic [36,37] antinociceptive [38][39][40], neuroprotective [41][42][43][44], sedative/motor relaxant [45][46][47], and antifungal [48,49] properties. This broad range of metabolites in different concentrations provides unique therapeutic applications for full spectrum extracts.…”

Section: Introductionmentioning

confidence: 99%

Converting Sugars into Cannabinoids—The State-of-the-Art of Heterologous Production in Microorganisms

et al. 2022

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The legal cannabis market worldwide is facing new challenges regarding innovation in the production of cannabinoid-based drugs. The usual cannabinoid production involves growing Cannabis sativa L. outdoor or in dedicated indoor growing facilities, followed by isolation and purification steps. This process is limited by the growth cycles of the plant, where the cannabinoid content can deeply vary from each harvest. A game change approach that does not involve growing a single plant has gained the attention of the industry: cannabinoids fermentation. From recombinant yeasts and bacteria, researchers are able to reproduce the biosynthetic pathway to generate cannabinoids, such as (-)-∆9-tetrahydrocannabinol (∆9-THC), cannabidiol (CBD), and (-)-∆9-tetrahydrocannabivarin (∆9-THCV). This approach avoids pesticides, and natural resources such as water, land, and energy are reduced. Compared to growing cannabis, fermentation is a much faster process, although its limitation regarding the phytochemical broad range of molecules naturally present in cannabis. So far, there is not a consolidated process for this brand-new approach, being an emerging and promising concept for countries in which cultivation of Cannabis sativa L. is illegal. This survey discusses the techniques and microorganisms already established to accomplish the task and those yet in seeing for the future, exploring upsides and limitations about metabolic pathways, toxicity, and downstream recovery of cannabinoids throughout heterologous production. Therapeutic potential applications of cannabinoids and in silico methodology toward optimization of metabolic pathways are also explored. Moreover, conceptual downstream analysis is proposed to illustrate the recovery and purification of cannabinoids through the fermentation process, and a patent landscape is presented to provide the state-of-the-art of the transfer of knowledge from the scientific sphere to the industrial application.

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Potentiation of antifungal activity of terbinafine by dihydrojasmone and terpinolene against dermatophytes

Cited by 11 publications

References 32 publications

Contribution of Constituents in Rosemary‐Magnolia Compound Essential Oil to Antibacterial, Antioxidant and Cytotoxicity Bioactivities Revealed by Grey Correlation Analysis

Contribution of Constituents in Rosemary‐Magnolia Compound Essential Oil to Antibacterial, Antioxidant and Cytotoxicity Bioactivities Revealed by Grey Correlation Analysis

Tropical Medicinal Plant Extracts from Indonesia as Antifungal Agents against Candida Albicans

Converting Sugars into Cannabinoids—The State-of-the-Art of Heterologous Production in Microorganisms

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