Potentiation effects of antimicrobial photodynamic therapy on quorum sensing genes expression: A promising treatment for multi-species bacterial biofilms in burn wound infections

Pourhajibagher, Maryam; Mahmoudi, Hassan; Rezaei-Soufi, Loghman; Alikhani, Mohammad Yousef; Bahador, Abbas

doi:10.1016/j.pdpdt.2020.101717

Cited by 20 publications

(12 citation statements)

References 41 publications

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“…Photodynamic therapy has been shown to be able to reduce the expression profile of the QS system genes associated with biofilm formation by A. baumannii . Pourhajibagher et al observed that in A. baumannii , P. aeruginosa , and S. aureus multispecies biofilms photosensitized with indocyanine green, the expression levels of abaI , agrA , and lasI , were downregulated, respectively [ 177 ]. These findings may have potential implications of photodynamic therapy for the treatment of multispecies bacterial biofilms involved in burn wound infections.…”

Section: Prevention and Treatment Strategies Against A Baumannii Biofilmmentioning

confidence: 99%

Gram-Negative Bacteria Holding Together in a Biofilm: The Acinetobacter baumannii Way

et al. 2021

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Bacterial biofilms are a serious public-health problem worldwide. In recent years, the rates of antibiotic-resistant Gram-negative bacteria associated with biofilm-forming activity have increased worrisomely, particularly among healthcare-associated pathogens. Acinetobacter baumannii is a critically opportunistic pathogen, due to the high rates of antibiotic resistant strains causing healthcare-acquired infections (HAIs). The clinical isolates of A. baumannii can form biofilms on both biotic and abiotic surfaces; hospital settings and medical devices are the ideal environments for A. baumannii biofilms, thereby representing the main source of patient infections. However, the paucity of therapeutic options poses major concerns for human health infections caused by A. baumannii strains. The increasing number of multidrug-resistant A. baumannii biofilm-forming isolates in association with the limited number of biofilm-eradicating treatments intensify the need for effective antibiofilm approaches. This review discusses the mechanisms used by this opportunistic pathogen to form biofilms, describes their clinical impact, and summarizes the current and emerging treatment options available, both to prevent their formation and to disrupt preformed A. baumannii biofilms.

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Section: Prevention and Treatment Strategies Against A Baumannii Biofilmmentioning

confidence: 99%

Gram-Negative Bacteria Holding Together in a Biofilm: The Acinetobacter baumannii Way

et al. 2021

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“…Simultaneously, it significantly reduces the number of bacterial cells and the expression level of QS genes of major pathogens on burn wounds. APDT with ICG combined with antibacterial, anti-biofilm, and gene expression inhibitors effectively treat multispecies bacterial biofilms correlated with burn and wound infection (80,81).…”

Section: Antimicrobial Pdt (Apdt)mentioning

confidence: 99%

Non-antibiotic methods against Pseudomonas aeruginosa include QS inhibitors: a narrative review

Xiang¹,

Ding²,

Cao³

et al. 2021

Ann Palliat Med

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The prevalence of antibiotic resistance is a growing worldwide problem in the control of pathogens, particularly negative bacteria that are resistant to antibiotics, Pseudomonas aeruginosa (PA) is one of these bacteria. The development of new effective antibiotics is time-consuming and costly, and the new antibiotics may become resistant again. Therefore, non-antibiotic clinical treatment for antibiotic-resistant PA infection is necessary and needs to be strengthened. The antibiotic resistance (AR) mechanism of PA is complex. Biofilm formation is one of the reasons why its resistance is difficult to overcome. The formation of biofilms is mainly regulated by quorum sensing (QS). QS is a mechanism by which PA increases its virulence by producing small diffusible molecules, which regulates a series of genes associated with virulence and nutrient acquisition. QS inhibitors are potions that obstruct QS systems in bacteria and destruction of virulence. This review summarizes AR mechanism of PA, Basic knowledge of QS of PA and some nonantibiotic methods for inhibiting PA, including QS inhibitors, which have potential and far-reaching significance for antibiotic-resistant PA's clinical treatment. The review helps to provide new ideas and new schemes for clinical anti-PA infection research and treatment, and has positive significance for delaying the occurrence of bacterial drug resistance and antibiotic use management.

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“…The RNAIII gene is the main effector of the agr system. It acts as a small RNA that regulates the expression of many virulence factors, including most of the genes that encode proteins associated with the cell wall and extracellular structures [50]. These factors are also associated with the formation of BF.…”

Section: Modulation In Gene Expression By Photodynamic Therapymentioning

confidence: 99%

“…Pourhajibagher et al [50], evaluated in multiple species, including S. aureus, the cell viability of bacterial BF subjected to ICG as a photosensitizer. The gene expression of the QS system and the arg gene was determined and compared to untreated bacteria.…”

Section: Modulation In Gene Expression By Photodynamic Therapymentioning

confidence: 99%

Photodynamic Treatment of Staphylococcus aureus Infections

Palavecino¹,

Pérez²,

Zúñiga³

2021

Photodynamic Therapy - From Basic Science to Clinical Research

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Introduction: Staphylococcus aureus is a Gram-positive coconut that causes various life-threatening infections and, in turn, represents a major producer of healthcare-associated infections. This pathogen is highly resistant to antibiotics, which has made it difficult to eradicate in recent decades. Photodynamic therapy is a promising approach to address the notable shortage of antibiotic options against multidrug-resistant Staphylococcus aureus. This therapy combines the use of a photosensitizing agent, light, and oxygen to eradicate pathogenic microorganisms. The purpose of this study is to provide relevant bibliographic information about the application of photodynamic therapy as an alternative antimicrobial therapy for Staphylococcus aureus infections. Methods: This review was achieved through a bibliographic search in various databases and the analysis of relevant publications on the subject. Results: A large body of evidence demonstrates the efficacy of photodynamic therapy in eliminating biofilm- or biofilm-producing strains of Staphylococcus aureus, as well as antibiotic-resistant strains. Conclusion: We conclude that photodynamic therapy against Staphylococcus aureus is a recommended antibacterial therapy that may complement antibiotic treatment.

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Potentiation effects of antimicrobial photodynamic therapy on quorum sensing genes expression: A promising treatment for multi-species bacterial biofilms in burn wound infections

Cited by 20 publications

References 41 publications

Gram-Negative Bacteria Holding Together in a Biofilm: The Acinetobacter baumannii Way

Gram-Negative Bacteria Holding Together in a Biofilm: The Acinetobacter baumannii Way

Non-antibiotic methods against Pseudomonas aeruginosa include QS inhibitors: a narrative review

Photodynamic Treatment of Staphylococcus aureus Infections

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