Potentiating Effect of Excessive Fructose Consumption on the Development of Obesity in Offspring of Gestational Stressed Mothers

Abstract

It has been shown that gestational stress of mothers leads to the birth of offspring with decreased body weight and a low level of leptin in the plasma. In adulthood in these offspring with the same amount of consumed food weight and fat mass higher than the corresponding figures in the offspring of mothers intact. The sons of stressed mothers established the presence of leptin resistance hypothalamic structures regulate the body’s energy, which is manifested in the absence of anorectic’s effects at hyperleptinemia. Long-term intake of fructose in the body the children of stressed mothers leads to aggravation due to leptin resistance and gestational already at a young age can contribute to the development of obesity.

Estrogens and female developing brain: two sides of the coin

“…In accordance with the concept of fetal origin of adult health and diseases [9][10][11], an early-life events can create the risks of diseases in the late periods of life [12][13][14][15]. Insufficiency or excess of nutritional factors during pregnancy can cause epigenomic changes in the developing fetus [16].…”