Potentiate the activity of current antibiotics by naringin dihydrochalcone targeting the AdeABC efflux pump of multidrug-resistant Acinetobacter baumannii

Verma, Privita; Tiwari, Monalisa; Tiwari, Vishvanath

doi:10.1016/j.ijbiomac.2022.07.065

Cited by 10 publications

(1 citation statement)

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“…These antibiotics can be used alone or combined. The ability of CRAB to resist antibiotic can be referred to its ability to produce carbapenemase enzyme, or alter the antibiotic binding site or cause outer membrane disruption or active efflux of the antibiotic (Verma et al 2022 ). Furthermore, this resistance has extended to K. pneumoniae , which has higher prevalence than any other Enterobacteriaceae member.…”

Section: Introductionmentioning

confidence: 99%

The impact and safety of encapsulated nanomaterials as a new alternative against carbapenem resistant bacteria. a systematic review

Abdallah,

Shebl,

Abdelsalam

et al. 2024

World J Microbiol Biotechnol

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The emergence of multi drug resistant bacterial infections has caused a critical problem with implication on hospitalization and mortality rates. This systematic review aims to review the combined antimicrobial effect of nanoparticles attached to the traditionally used antibiotics, to overcome the antibiotic resistance crisis. In this systematic search we focused on preclinical studies that have used animal models, to test and evaluate the effect of nanomaterials added to antibiotics against gram negative bacteria with carbapenem resistance. Where, this newly formed structure has led to significant decrease in bacterial load in animal model serum. Furthermore, by evaluating nanomaterial cytotoxicity and inflammatory markers, promising results were established, where low toxicity indices were presented, supporting the ability of this new pathway to be used as an alternative to abused antibiotics. Our research collected the various data and showed encouraging preclinical one for using nanomaterials with antibiotics. This undeniable route should be considered, due to its ability to contribute to the treatment of multi drug resistant bacterial infections. These findings provide base for future studies and reinforce the need for more evaluation and testing on the safety of nanomaterials against bacterial infections.

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Section: Introductionmentioning

confidence: 99%