Potentialy Of Flavonoid Miana (Coleus Atropurpereus) Leaves Estract As Anti Mycobacterium Tuberculosis H37rv Strain And Mdr With Microscopy Observation Drug Susceptibility (Mods)

Abstract

There is high resistance cases for Isoniazid and Rifampin and more famous withMulti-drug resistant tuberculosis (MDR-TB). From data in Makassar, South sulawesishowed 19,2 MDR-TB cases from new TB patient, and more 13,5% resistance cases forfirstline-TB drugs (STR, INH, RIF,and ETH), and >2 resistance for secondline-TBdrugs (OFL,KAN,AMK). Treatment for tuberculosis mostlly not effective because Multidrugresistanttuberculosis (MDR-TB) cases is very high.WHO recomended traditionalmedicine for improvement of healthy in coummunity, preventive and pharmaceuticalpreparation for all diseases. Research in 2013 showed 85,71% that Torajas TB patientin South Sulawesi used traditional medicine such as Miana (Coleus atropurpereus)leaves estract as complement for TB drugs. Our study showed flavonoid component fromqualitative method used sianida (HCl-Mg) from ethanol 96% Miana (Coleusatropurpereus) leaves estract .Qualitative method using Spektrofotometer UV-V showedthe total of flavonoid component from ethanol 96% miana (Coleus atropurpereus) leavesestract is 8,59 mgRE/gram ekstract.. The result showed were at concentrations (10%,20% ,40 % , 60 % ,80 % and 100%) ethanol 96% miana (Coleus atropurpereus) leavesestract were effecttively inhibit Mycobacterium tuberculosis H37RV strain. Were atconcentration (10%, 20% ,40 % dan 60 %) ethanol 96% miana (Coleus atropurpereus)leaves estract were not effecttively inhibit MDR-TB but effecttively were at concentration (80 % and 100%).

Toll Like Receptor 4 Expression Profile in Mice Infected Mycobacterium Tuberculosis Given with Miana Leaves Extract (Coleus scutellarioides (L.) Benth) (Tuberculosis Preventive and Curative Mechanisms)

“…Secondary metabolites in EDM function as antibacterials with various mechanisms such as immunostimulants, cytokine immunodepressants, inhibiting cell DNA synthesis, agglutinating proteins, damaging cell wall membranes. 23,[27][28][29] The use of OAT as antituberculosis takes months, 6 months and even 9 months. The length of the treatment period allows side effects that cause treatment to be interrupted and cure is not achieved.…”

Preparasi dan Karakterisasi Sistem Pembawa Liposom dari Ekstrak Etanol Daun Miana (Coleus atropurpureus L. Benth)

“…Formasi pigmen di dalam daun ditentukan secara genetik dan juga dipengaruhi faktor lingkungan seperti cahaya dan lingkungan. Corak, bentuk dan warna miana beranekaragam, tetapi yang berkhasiat obat adalah daun yang berwarna merah kecoklatan [1]. Tanaman yang dikelompokkan ke dalam jenis tanaman hias ini ternyata memiliki khasiat yang sangat banyak.…”

“…Telah diketahui beberapa studi yang dilakukan tentang senyawa aktif daun miana (Coleus atropurpereus) yaitu berupa flavonoid, saponin, steroid, tanin, minyak atsiri, eugenol, senyawa polifenol, alkaloid, etil salisilat, kalsium oksalat, senyawa rosmarinic acid (RA) [1]. Salah satu senyawa yang bermanfaat pada tanaman ini adalah flavonoid berupa antosianin [3].…”

Characteristics and quality of eggs from laying hens fed on Miana plant flour (Coleus atropurpureus L.)

“…The leaves are triangular or ovoid in shape and vary in color from green to purplish-red. The flowers are in the form of stacked strands at the top of the stalk with variations in red or white, purple or yellow [3]. Mano (2018) stated that miana is an ornamental plant that can be used as traditional medicine originating from Southeast Asia.…”