Potentials of Two Nigerian Spices—&amp;lt;i&amp;gt;Piper nigrum&amp;lt;/i&amp;gt; and &amp;lt;i&amp;gt;Monodora myristica&amp;lt;/i&amp;gt; as Sources for Cheap Natural Antioxidants

Uyoh, Edak Aniedi; Chukwurah, Peter Nkachukwu; Akarika, Roseline C.; Antia, Victoria A.

doi:10.4236/ajps.2013.45137

Cited by 7 publications

(7 citation statements)

References 21 publications

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“…T. tetraptera oleoresin obtained the second-highest absorbance values, while M. myristica oleoresins had the least absorbance levels . The TAC recorded in this current work seemed higher than those of M. myristica 35 , including those of aqueous and ethanolic extracts of fruits, pulps, and seeds of T. tetraptera 8 . Nonetheless and for emphasis, the TAC assay is based on the ability of a reducing agent (antioxidant) to reduce molybdenum (VI) ions to molybdenum (V) giving a green phosphomolybdate (V) complex at 765 nm 20 , 37 , 39 .…”

Section: Resultscontrasting

confidence: 61%

“…For example, the highest concentration (640 µg/mL) of T. tetraptera oleoresin obtained maximum scavenging power (93.46%) that appeared significantly higher (p < 0.05) compared to the others, which specifically demonstrates enhanced antioxidant properties. Previous reports show roughly 29–37.7% scavenging powers of M. myristica seeds could concur with maximum concentration of 120 µg/mL 35 , contrasting 10–41% when concentration is maximum at 400 µg/mL 7 . Lower DPPH scavenging has been recorded at T. tetraptera fruit and bark ethanolic and hydroethanolic extracts 1 , 4 , 36 .…”

Section: Resultsmentioning

confidence: 76%

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Chemical composition, antibacterial efficacy, and antioxidant capacity of essential oil and oleoresin from Monodora myristica and Tetrapleura tetraptera in Southeast Nigeria

Okechukwu

Ugwuona

Ofoedu

et al. 2022

Sci Rep

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Specific to the West African sub-region, previous studies involving fruit, stem, and bark of Tetrapleura tetraptera as well as seeds of Monodora myristica have largely focused on phytochemical properties of aqueous and methanolic and ethanolic extracts. To supplement existing information, the chemical composition, antibacterial efficacy (tested against Escherichia coli and Staphylococcus aureus), and antioxidant capacity (1,1-diphenyl-2-picrylhydrazyl (DPPH∙) radical scavenging, ferric reducing power, and total antioxidant capacity) of essential oil and oleoresin extracted from T. tetraptera fruit and M. myristica seeds cultivated in Southeast Nigeria, were studied. Essential oil and oleoresin were respectively extracted by steam distillation and aqueous maceration. By way of gas chromatograph mass spectrometry (GC–MS) analysis, the chemical compounds from essential oil and oleoresin from M. myristica and T. Tetraptera samples totaled 6 and 5, as well as 27 and 16, respectively. Besides the oleoresin of M. myristica and the essential oil of T. tetraptera showing some resistance against S. aureus, the oleoresins seemed highly susceptible to E. coli—all of which demonstrated concentration-dependence to the antibacterial inhibition zone. Scavenging DPPH radical, reduction power activity, and total antioxidant capacity increased with essential oil and oleoresin extracts' concentrations, which positions M. myristica and T. tetraptera spices as very promising for food preservation, especially against autoxidation and microbial spoilage.

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Section: Resultscontrasting

confidence: 61%

Section: Resultsmentioning

confidence: 76%

Chemical composition, antibacterial efficacy, and antioxidant capacity of essential oil and oleoresin from Monodora myristica and Tetrapleura tetraptera in Southeast Nigeria

Okechukwu

Ugwuona

Ofoedu

et al. 2022

Sci Rep

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“…The total phenolic content of the extract which was 965.01 μ g equivalent of gallic acid/mg was, however, less than the 9.8–15.9 mg catechin equivalent/g of the three Piper species reported by Agbor and colleagues [ 32 ]. The antioxidant property of P. nigrum is largely due to the flavonoids and phenols present in the extracts which protect the body against free radical damage [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…Phytochemical screening was performed to detect the presence of some active components in the PNS crude extract using the method of Harborne [ 38 ]. These active components were alkaloids, phenols, tannins, saponins, steroids, anthocyanins, flavonoids, and anthraquinones.…”

Section: Methodsmentioning

confidence: 99%

Protective and Ameliorative Effects of Hydroethanolic Extract of Piper nigrum (L.) Stem against Antiretroviral Therapy-Induced Hepatotoxicity and Dyslipidemia in Wistar Rats

Enyang,

Sonibare,

Tchamgoue

et al. 2024

Journal of Toxicology

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Antiretroviral therapy (ART) has revolutionized the lives of people living with HIV/AIDS by overall improving their quality of life and increasing life expectancy. However, ART-associated hepatotoxicity and metabolic disorders in HIV/AIDS patients are growing concerns to clinicians, especially due to the long-term use of the drugs. This study reported on the phytochemical and pharmacological profile of hydroethanolic extracts of Piper nigrum stem (PNS) and evaluated its protective effect against tenofovir/lamivudine/efavirenz (TLE)-induced hepatotoxicity and dyslipidemia in Wistar rats. Cytotoxic, antioxidant, and anti-inflammatory assays were performed on PNS. Thirty-six rats divided into 6 groups of 6 animals/group were administered: distilled water, 17 mg/kg TLE, 17 mg/kg TLE and 100 mg/kg silymarin, 17 mg/kg TLE, and Piper extract (200 mg/kg, 400 mg/kg, or 800 mg/kg) orally for 28 days. The body weight of animals was recorded every 7 days. On Day 29, the rats were sacrificed, and blood samples were collected for hematological and biochemical tests. Portions of the liver and kidneys were collected for histological evaluation, while liver homogenates were prepared from the rest to measure antioxidant enzymes. PNS possessed in vitro cytotoxic, antioxidant, and anti-inflammatory activities. A significant decrease p<0.05 in the body weight of rats treated with PNS was observed. A significant high platelet count p<0.05 was observed in the PNS800 mg/kg group. A considerable decrease in alkaline phosphatase and triglycerides was observed in the silymarin and PNS group compared to the TLE-only group. The findings also show a significant increase in catalase and glutathione in the TLE-only group compared to the normal group, while SOD decreased. Histological observations revealed normal hepatic and renal tissues in the silymarin, and PNS-treated groups compared to the normal control, while leucocyte infiltration was observed in the TLE-only group. These results suggest that PNS extract possessed antioxidant activity that alleviated TLE-induced toxicity. Further studies are necessary to understand the pharmacokinetic interactions between ART and PNS.

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“…It consists of about 109 genera and 2440 species (Couvreur et al 2012). Economically, the family is important as a source of edible fruits (Aziz et al 2016);cosmetics and perfumes (Leboeuf et al 1982;Bele et al 2011, Akpabio andAkpapan 2012;Uyoh et al 2013;Handayani 2016); timber (Nurfadilah et al 2017); traditional medicines (Wang et al 2002;Blessing et al 2010;Purwantiningsih et al 2011;Wang et al 2012;Rosandy et al 2013;Biba et al 2014;Enabulele et al 2014); processed foods and beverages (Bele et al 2011;Akpabio and Akpapan 2012;Eze-Steven et al 2013;Tatdao et al 2014); ornamental plants (Handayani 2016;Handayani 2017); pesticides (Bele et al 2011;Cheng et al 2012); and other comodities (Wakhidah et al 2017). Members of the Annonaceae play an important ecological role in terms of species diversity, especially in tropical rainforest ecosystems (Couvreur et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Diversity, potential and conservation of Annonaceae in Bogor Botanic Gardens, Indonesia

Handayani

2018

Biodiversitas

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Handayani T. 2018. Diversity, potential and conservation of Annonaceae in Bogor Botanic Gardens, Indonesia. Biodiversitas 19: 591-603. The Annonaceae is a large family of trees, shrubs and climbers consisting of about 109 genera and 2440 species. This family has important economic value for fresh fruit, cosmetics and perfumes, timber, traditional medicines, processed foods and beverages, insecticides, and ornamental plants. It also has an important role in forest ecosystems and in environmental management, as a key habitat organism. Despite its many uses, the family has not received special attention, and many of its species have been forgotten. Therefore, efforts are required to conserve the Annonaceae. Conservation of the Annonaceae depends upon ex-situ as well as in-situ methods. Conservation by ex situ approaches is considered effective because it can save from extinction species that are rare, endemic or of as yet recognized, unknown usefulness.The research reported in this paper aimed to determine Annonaceae diversity in Bogor Botanic Gardens (BBG), West Java, Indonesia as well as its current and potential utilization, with a view to developing ways of ensuring preservation of the collection within the Gardens. The study used direct observation of the Garden’s collection, compilation and scrutiny of relevant data from the long-term BBG registration database, analysis of past research data, and a literature study. Currently, BBG holds in its collection about 28 genera and 83 species of the Annonaceae family. The collection is estimated to cover 80% of the total species scattered across the Malesian region. Within the collection there are 49 tree species (59.04%), 14 shrub species (16.87%) and 20 liana species (24.09%). Most of the collections are from Java and Sumatra, while the fewest are from Maluku Islands and Papua. Among 40 species observed, 7 species are used for their fruit, 7 species have cosmetic or perfume uses, 22 species are a source of timber, 34 species have uses in traditional medicine, 6 species are used in the food or beverage industry, 19 species can be used as ornamental plants, 8 species for insecticides, and 4 species for other uses.The Annonaceae collections consist of young and old plants.Plants within the Gardens that are more than 100 years old include trees (7 species), shrubs (3 species) and a liana (1 species).The most widely used parts for traditional medicine are roots and leaves. This paper discusses the efforts taken by BBG to conserve the Annonaceae, include maintaining the diversity of the collection, researching the potential usefulness of the collection and exploring different approaches to its conservation.

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Potentials of Two Nigerian Spices—<i>Piper nigrum</i> and <i>Monodora myristica</i> as Sources for Cheap Natural Antioxidants

Cited by 7 publications

References 21 publications

Chemical composition, antibacterial efficacy, and antioxidant capacity of essential oil and oleoresin from Monodora myristica and Tetrapleura tetraptera in Southeast Nigeria

Chemical composition, antibacterial efficacy, and antioxidant capacity of essential oil and oleoresin from Monodora myristica and Tetrapleura tetraptera in Southeast Nigeria

Protective and Ameliorative Effects of Hydroethanolic Extract of Piper nigrum (L.) Stem against Antiretroviral Therapy-Induced Hepatotoxicity and Dyslipidemia in Wistar Rats

Diversity, potential and conservation of Annonaceae in Bogor Botanic Gardens, Indonesia

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