Potentially Same Novel <i>Ehrlichia</i> Species in Horses in Nicaragua and Brazil

Vieira, Thállitha Samih Wischral Jayme; Qurollo, Barbara A.; Mongruel, Anna Cláudia Baumel; Baggio, Rafael Antunes; Vidotto, Odilon; Breitschwerdt, Edward B.; Vieira, Rafael Felipe da Costa

doi:10.3201/eid2405.172076

Cited by 15 publications

(7 citation statements)

References 5 publications

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“…Consequently, further molecular diagnostic assays are needed for determination of the causative agent. A recent study from South America based on phylogenetic analysis of the 16S rDNA, sodb, and groEL genes and translated amino acids found that Brazilian and Nicaraguan Ehrlichia isolates from horses probably belong to the same novel Ehrlichia species infecting horses, differing from E. ruminantium (Vieira et al, 2018). Still, the vector, the biology and the pathogenicity of the novel Ehrlichia species infecting equines are not known.…”

Section: And Ninementioning

confidence: 99%

Seroprevalence of Anaplasma phagocytophilum, Ehrlichia spp. and Borrelia burgdorferi infections in horses: first report from Northern Bulgaria – Short communication

Tsachev

Baymakova

Pantchev

2019

Acta Veterinaria Hungarica

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Lyme borreliosis, granulocytic anaplasmosis and monocytic ehrlichiosis are well studied in humans and dogs. In horses, these diseases are not widely investigated and limited information is available about their occurrence. The purpose of this study was to present the first ELISA-based report on the seroprevalence of Anaplasma phagocytophilum, Ehrlichia spp. and Borrelia burgdorferi in horses from Northern Bulgaria. A total of 192 horses were investigated from three regions in Northern Bulgaria (Northwestern, North-Central and Northeastern Bulgaria). All equine sera were tested for A. phagocytophilum, Ehrlichia spp. and B. burgdorferi antibodies by a commercial rapid ELISA test. Antibodies against A. phagocytophilum were found in all the three regions at a mean frequency of 12% (23/192), ranging from 9.38 to 15.63% by region. Antibodies against Ehrlichia spp. were found in horses from one region (Northeastern) at a rate of 0.5% (1/192). Anti-B. burgdorferi antibodies were detected in all the three regions with a mean frequency of 15.1% (29/192), ranging from 14.06 to 17.19% by region. A co-exposure to A. phagocytophilum and B. burgdorferi was observed in 6.3% of the cases (12/192). This is the first report on the natural exposure of horses to these bacteria (A. phagocytophilum, Ehrlichia spp. and B. burgdorferi) in Northern Bulgaria.

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Section: And Ninementioning

confidence: 99%

Seroprevalence of Anaplasma phagocytophilum, Ehrlichia spp. and Borrelia burgdorferi infections in horses: first report from Northern Bulgaria – Short communication

Tsachev

Baymakova

Pantchev

2019

Acta Veterinaria Hungarica

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“…Several recent studies from North America (South Central United States, Oklahoma), South America (Brazil), and Central America (Nicaragua) documented reactivity to Ehrlichia spp. in horse serum [ 42 , 43 ], and molecular and phylogenetical studies suggest a potentially novel Ehrlichia species different from currently recognized species [ 22 , 44 ]. However, the main vector and the clinic significance of this newly identified equine Ehrlichia species are yet unknown.…”

Section: Discussionmentioning

confidence: 99%

“…A previous study in Romania confirmed the presence of E. canis DNA in ticks infesting dogs, in southeast Romania [ 45 ]. However, future extended surveys are planned to provide additional data for understanding if Romanian horses are reactive to E. canis or to a potential novel Ehrlichia species, as recently described [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Serological Evidence of Natural Exposure to Tick-Borne Pathogens in Horses, Romania

2021

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The purpose of this study was to investigate the seroprevalence of selected tick-borne-pathogens (TBPs) among Romanian horses. For this, a total of 223 animals originating from north, central, and southeast Romania, including horses from stud farms (n = 118) and working horses (n = 105), were tested using a commercial rapid ELISA-based test. Overall, 10.3% (95% confidence interval (CI): 6.7–15.1%) of the tested horses were seropositive for antibodies (Ab) against Anaplasma phagocytophilum. Additionally, 18.8% (95% CI: 13.9–24.6%) and 0.5% (95% CI: 0.01–2.5%) of horses were seropositive for Ab against Borrelia burgdorferi sensu lato and Ehrlichia spp., respectively. Among the tested horses, 3.1% were seroreactive to two or three pathogens. These findings show the natural exposure of Romanian horses to zoonotic tick-borne pathogens and emphasize the need for further studies to better understand the epidemiology of equine tick-borne diseases in Romania.

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“…Besides, E. ruminantium as well as several closely related Ehrlichia species, E. ewingii, E. canis and E. muris-like agent have also been proved to infect human [10][11][12][13][14]40]. Although some Ehrlichia species were characterized from ticks or vertebrate animals in recent years [6,[41][42][43][44][45], few studies have been carried out on their pathogenicity to human beings. In this study, due to the far relationship between Candidatus E. hainanensis and other Ehrlichia species, it is di cult to speculate whether it may infect human or not.…”

Section: Discussionmentioning

confidence: 99%

Molecular Detection and Identification of “Candidatus Ehrlichia hainanensis”, A novel Ehrlichia Species in Rodents from Hainan Province, China

Zhao

Xue

et al. 2020

Preprint

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Background: Ehrlichia is a genus of Rickettsiales bacteria closely related to human/animal disease and it plays an important role in public health. Naturally they are hosted by mammals such as canines, bovines, wild rodents and vectored by ticks. Results: In this study, we collected 121 rodent samples including 67 Niviventer fulvescens, 27 Rattus tanezumi, 24 Chiromyscus sp., 2 Rattus nitidus and 1 Leopoldamys edwardsi from Hainan province, which consists of the second largest island in China. The presence and genetic diversity of Ehrlichia was evaluated and characterized by amplifying and sequencing the 16S rRNA, groEL and gltA genes. An Ehrlichia was detected in 5 of the 67 Niviventer fulvescens samples (7.46%). The 16S rRNA, groEL and gltA genes show highest 99.20%, 89.87% and 83.86% identity to known Ehrlichia sequences. In the phylogenetic trees they form a distinct cluster from any other species.Conclusions: We propose that this Ehrlichia present a putative novel species nominated as ‘Candidatus Ehrlichia hainanensis’. Its pathogenicity to human is still to be further researched and molecular surveillance in local populations is needed.

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Potentially Same Novel Ehrlichia Species in Horses in Nicaragua and Brazil

Cited by 15 publications

References 5 publications

Seroprevalence of Anaplasma phagocytophilum, Ehrlichia spp. and Borrelia burgdorferi infections in horses: first report from Northern Bulgaria – Short communication

Seroprevalence of Anaplasma phagocytophilum, Ehrlichia spp. and Borrelia burgdorferi infections in horses: first report from Northern Bulgaria – Short communication

Serological Evidence of Natural Exposure to Tick-Borne Pathogens in Horses, Romania

Molecular Detection and Identification of “Candidatus Ehrlichia hainanensis”, A novel Ehrlichia Species in Rodents from Hainan Province, China

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