Potentially pathogenic circulating autoantibodies to cardiac troponin are present in hemodialysis patients

Jefferies, Helen J.; Tertti, Risto; Wittfooth, Saara; Burton, James O.; Metsärinne, Kaj; Pettersson, Kim; McIntyre, Christopher W.

doi:10.1111/hdi.12514

Hemodialysis International

2016

DOI: 10.1111/hdi.12514

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Potentially pathogenic circulating autoantibodies to cardiac troponin are present in hemodialysis patients

Helen J. Jefferies

Risto Tertti

Saara Wittfooth

et al.

Abstract: This is the first description of cTnAAb in HD patients, which raises the possibility that longitudinal exposure to repetitive HD-induced cardiac injury may lead to further autoimmune-based myocardial insult.

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2024

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Home Dialysis in Patients with Cardiovascular Diseases

Reaves,

Weiner,

Sarnak

2024

CJASN

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Kidney failure with replacement therapy and cardiovascular disease are frequently comorbid. In patients with kidney failure with replacement therapy, cardiovascular disease is a major contributor to morbidity and mortality. Conventional thrice-weekly in-center dialysis confers risk factors for cardiovascular disease including acute hemodynamic fluctuations and rapid shifts in volume and solute concentration. Home hemodialysis (HD) and peritoneal dialysis (PD) may offer benefits in attenuation of cardiovascular disease risk factors primarily through improved volume and blood pressure control, reduction (or slowing progression) of left ventricular mass, decreased myocardial stunning, and improved bone and mineral metabolism. Importantly, while trial data are available for several of these risk factors for home HD, evidence for PD is limited. Among patients with prevalent cardiovascular disease, home HD and PD may also have potential benefits. PD may offer particular advantages in heart failure given it removes volume directly from the splanchnic circulation, thus offering an efficient method of relieving intravascular congestion. PD also avoids the risk of blood stream infections in patients with cardiac devices or venous wires. We recognize that both home HD and PD are also associated with potential risks and these are described in more detail. We conclude with a discussion of barriers to home dialysis and the critical importance of interdisciplinary care models as one component of advancing health equity with respect to home dialysis.

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Home Dialysis in Patients with Cardiovascular Diseases

Reaves,

Weiner,

Sarnak

2024

CJASN

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Potentially pathogenic circulating autoantibodies to cardiac troponin are present in hemodialysis patients

Abstract: This is the first description of cTnAAb in HD patients, which raises the possibility that longitudinal exposure to repetitive HD-induced cardiac injury may lead to further autoimmune-based myocardial insult.

Cited by 1 publication

References 20 publications

Home Dialysis in Patients with Cardiovascular Diseases

Home Dialysis in Patients with Cardiovascular Diseases

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