Potentially inappropriate prescribing (IP) for elderly medical inpatients in Taiwan: A hospital-based study

Liu, Chien‐Liang; Peng, Li Ning; Chen, Yi Tsun; Lin, Ming Hsien; Liu, Li Kuo; Chen, Liang Kung

doi:10.1016/j.archger.2011.07.001

Cited by 77 publications

(101 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, their application may be more suitable in the clinical context for a comprehensive medication review of individual patients. They have been used by researchers in different jurisdictions in Europe and elsewhere to evaluate the quality of prescribing in the elderly (120)(121)(122)(123)(124), and have been endorsed as being an appropriate choice for evaluating the quality of prescribing of elderly patients with multiple chronic conditions (125,126).…”

Section: Explicit Potentially Inappropriate Prescriptions Criteriamentioning

confidence: 99%

“…STOPP criteria were selected to evaluate the quality of prescribing, as these criteria have been endorsed by different jurisdictions and research groups in Europe and elsewhere to evaluate the quality of prescribing in the elderly (120)(121)(122)(123)(124)(125)(126), and in order to facilitate the comparison with other studies. However, there are nationally developed criteria that have been adapted to Swedish settings (111).…”

Section: Potentially Inappropriate Prescribing In the Elderlymentioning

confidence: 99%

See 1 more Smart Citation

Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects

Hedna

2015

View full text Add to dashboard Cite

Aim:The aim of this thesis is to estimate and analyse the burden of potentially inappropriate prescriptions (PIPs) in the elderly and non-adherence to long-term medications among adults across care settings, and to investigate how IUM is associated to DRMs. Methods:A meta-analysis summarised the previous evidence on the percentage of adverse drug reactions (ADRs) associated to IUM across healthcare settings (Study I). From a cohort in the general population, using medical records and register data, the prevalence of PIPs in the elderly and its association with ADRs were estimated retrospectively (Study II). From the same cohort, the factors associated with refill non-adherence to antihypertensive therapy, considering the use of multiple medications, and the association between non-adherence and sub-therapeutic effects (STEs) were investigated (Study III). A survey assessed the refill behaviour to antihypertensive, lipid lowering and oral antidiabetic medications (undersupply, adequate supply and oversupply), and its association with perceived ADRs and STEs (Study IV).Results: IUM was the cause 52% and 45% of ADRs occurring in adult outpatients and inpatients respectively. Across healthcare settings, 46% of the elderly refilled PIPs over a 6-month period;PIPs were considered the cause of 30% of all ADRs; and the elderly who were prescribed PIPs had increased odds to experience ADRs (OR 2.47, 95% CI 1.65-3.69). In total, 35% was nonadherent to the full multidrug therapy and 13% was non-adherent to any medication (complete vi non-adherence). Sociodemographic factors (working age and lower income) were associated with non-adherence to any medication, while clinical factors (use of specialised care, use of multiple medications, and being a new user) with non-adherence to the full multidrug therapy. STEs were associated with non-adherence to any medication a month prior to a healthcare visit (OR 3.27, 95% CI 1.27-8.49), but not with long-term measures of non-adherence. Among survey respondents, 22% of the medications were oversupplied and 12% were undersupplied. Inadequate refill behaviour was not associated with reporting ADRs or STEs (p<0.05). Conclusions:A large proportion of ADRs occurring in hospital is caused by IUM, but more knowledge is needed in other settings. PIPs are common in the elderly general population and associated with ADRs. Therefore decreasing PIPs could contribute towards ADR prevention.Considering the use of multiple medications may help to better understand the factors associated with non-adherence to a multidrug therapy for tailoring the interventions to patient needs.Monitoring the adherence prior to a healthcare visit may facilitate interpreting STEs. Yet, the absence of an association between long-term measures of refill non-adherence with clinical and perceived DRMs suggest the need to enhance the knowledge of this association in clinical practice.In summary, this thesis shows a significant potential for improvements of medication use and outcomes.Key words: Drug-related morbidity, medica...

show abstract

Section: Explicit Potentially Inappropriate Prescriptions Criteriamentioning

confidence: 99%

Section: Potentially Inappropriate Prescribing In the Elderlymentioning

confidence: 99%

Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects

Hedna

2015

View full text Add to dashboard Cite

show abstract

“…Many of the studies on medication use in the elderly focus on inpatients, outpatients or those living in the community (Flores, Mengue, 2005;Winit-Watjana, Sakulrat, Kespichayawattana, 2008;Lin et al, 2011;Rajska-Neumann et al, 2011;Varallo et al, 2011;Liu et al, 2012;Pinto, Ferre, Pinheiro, 2012), while research on drug use by elderly institutionalized adults is still scarce (Correr et al,2007;Aguiar et al, 2008;O'Mahony et al, 2010;Fochat et al, 2012). The purpose of this study was to identify and quantify drug use in elderly institutionalized adults using the Beers Criteria (2012).…”

Section: Introductionmentioning

confidence: 99%

“…Institutionalized older adults differ from those who live with their families as they present specific characteristics such great frailty, impaired functionality, and physical, psychological and social dependence (Gorzoni, Pires, 2006). Comorbidities and chronic degenerative diseases make the elderly prone to using concomitant medications, increasing the risk of adverse events occurrence (RajskaNeumann et al, 2011;Liu et al, 2012 The need for caution in prescribing drugs to older adults has led to the development of a number of tools to assist this practice. One of these resources is the Beers Criteria of potentially inappropriate medications (PIM) use in older adults, developed by Beers et al (1991).…”

Section: Introductionmentioning

confidence: 99%

Potentially inappropriate medication use in institutionalized older adults according to the Beers Criteria

Ganassin

Matos

Toffoli-Kadri

2014

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

The need for specific care, coupled with new family arrangements, has contributed to the increasing institutionalization of elderly members. The purpose of this study was to evaluate drug use by institutionalized older adults according to Beers Criteria. This prospective, longitudinal study was conducted in the three non-profit long-stay geriatric care institutions of Campo Grande, in the Central-West region of Brazil. All subjects aged 60 years and above on November 2011 were included and followed until November 2012. Eighteen subjects were excluded and the final sample consisted of 133 individuals aged 60 to 113 years. Overall, 212 medications were used at geriatric care institution A, 532 at B, and 1329 at C. Thirty-four drugs were inappropriately prescribed 89 times at geriatric care institution A (41.98%), 49 prescribed 177 times at B (33.27%), and 91 prescribed 461 times at C (34.68%). Statistical differences in the inappropriate drug use were found between genders (p=0.007). The most commonly used potentially inappropriate medication were first-generation antihistamines (15.34%). There was a high frequency in the use of potentially inappropriate medications which can initiate marked side effects and may compromise the fragile health of institutionalized elderly. Thus, adopting the Beers Criteria in prescribing medication contributes to minimize adverse reactions and drug interactions.

show abstract

“…Using STOPP criteria PIMs were found in 29-44% of acutely ill hospitalized patients, primary care centers and nursing homes from different countries (Gallagher, O'Mahony, 2008;Cahir et al, 2010;Liu et al, 2012;Ubeda et al, 2012;Bradley et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Exposure to potentially inappropriate medications in Brazilian elderly outpatients with metabolic diseases

Martins

Mori

Dórea

et al. 2016

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

Potentially inappropriate prescribing (IP) for elderly medical inpatients in Taiwan: A hospital-based study

Cited by 77 publications

References 24 publications

Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects

Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects

Potentially inappropriate medication use in institutionalized older adults according to the Beers Criteria

Exposure to potentially inappropriate medications in Brazilian elderly outpatients with metabolic diseases

Contact Info

Product

Resources

About