Potentially Inappropriate Medications Use among Older Adults with Comorbid Diabetes and Hypertension in an Ambulatory Care Setting

Alwhaibi, Monira

doi:10.1155/2022/1591511

Cited by 9 publications

(8 citation statements)

References 33 publications

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“…Following exclusion of 213 duplicate studies, 1258 studies were excluded by the titles and abstracts. Ninety-four studies with 371 224 692 older outpatients were included for analysis (Figure 1; eAppendix 2 in Supplement 1).…”

Section: Resultsmentioning

confidence: 99%

“…Forty-one studies were conducted in Asia, followed by 22 studies in Europe, 14 studies in North America, 8 studies in South America, 7 studies in Africa, and 2 studies in Oceania. Between 1999 and 2021, a total of 51 studies were performed in high-income countries, 23 studies in upper- to middle-income countries, 17 studies in lower- to middle-income countries, and 3 studies in low-income countries. Sixty-three studies of the PIM prevalence estimates were based on the Beers criteria, 26 studies…”

Section: Resultsmentioning

confidence: 99%

“…Between 1999 and 2021, a total of 51 studies were performed in high-income countries, 23 studies in upper- to middle-income countries, 17 studies in lower- to middle-income countries, and 3 studies in low-income countries. Sixty-three studies of the PIM prevalence estimates were based on the Beers criteria, 26 studies were based on the STOPP/START criteria, 13 studies on localization criteria that were developed based on the characteristics of medication for older patients in their own country, and 13 studies on other criteria. Eighty-five studies…”

Section: Resultsmentioning

confidence: 99%

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Prevalence of Use of Potentially Inappropriate Medications Among Older Adults Worldwide

Tian,

Chen,

Zeng

et al. 2023

JAMA Netw Open

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ImportanceThe use of potentially inappropriate medications (PIMs) is widespread yet continues to receive little attention in outpatient services.ObjectiveTo estimate the overall prevalence of PIM use in outpatient services.Data SourcesPubMed, Embase, and Web of Science were searched to identify relevant studies published from January 1, 1990, to November 21, 2022.Study SelectionObservational studies that reported the prevalence of PIM use among older patients in outpatient services were screened.Data Extraction and SynthesisTwo reviewers independently selected eligible articles, extracted data, and assessed the risk of bias. A random-effects meta-analysis was conducted to pool the prevalence estimates.Main Outcomes and MeasuresThe global patterns in the prevalence of PIM use among older patients in outpatient services were estimated, and the temporal trends and regional differences in PIM use were investigated.ResultsA total of 94 articles with 132 prevalence estimates were analyzed, including nearly 371.2 million older participants from 17 countries. Overall, the pooled prevalence of PIM use was 36.7% (95% CI, 33.4%-40.0%). Africa had the highest prevalence of PIM use (47.0%; 95% CI, 34.7%-59.4%), followed by South America (46.9%; 95% CI, 35.1%-58.9%), Asia (37.2%; 95% CI, 32.4%-42.2%), Europe (35.0%; 95% CI, 28.5%-41.8%), North America (29.0%; 95% CI, 22.1%-36.3%), and Oceania (23.6%; 95% CI, 18.8%-28.8%). In addition, the prevalence of PIM use is highest in low-income areas. Use of PIMs among older patients has become increasingly prevalent in the past 2 decades.Conclusions and RelevanceThis study of patterns of PIM use by different groups, such as geographic regions and World Bank countries, suggests noticeable geographic environment and economic income differences in the burden of PIMs in outpatient services. Furthermore, the high prevalence trend in the past 2 decades indicates that the global burden of PIM use continues to be worthy of attention.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Prevalence of Use of Potentially Inappropriate Medications Among Older Adults Worldwide

Tian,

Chen,

Zeng

et al. 2023

JAMA Netw Open

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“…It is clear that elders with comorbid conditions such as diabetes and hyperlipidemia demand a combination of antihypertensive medication. Focus on comorbid of hypertension and diabetes, it has the negative effect of potential inappropriate medication in almost one of two individuals with at least taken seven medications [32]. The rule of comorbid as one of the key factors to achieve blood pressure control may not be eliminated, but there are still many strategies that need to be explored as the effort to control the incidence of unpredictable complications.…”

Section: Discussionmentioning

confidence: 99%

The Most Common Predictors of Uncontrolled Blood Pressure Among Hypertensive Elders: A Systematic Review

Dewi¹,

Ahmad²

2023

International Journal of Advanced Health Science and Technology

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Aging process implies challenges for the elderly, specifically related to degeneration in the vascular system. Elderly living with hypertension considers to undergo ongoing treatment to prevent severe brain, heart and kidney damage. Hypertension is getting harder to control if the patients unaware with the factors that outweigh blood pressure control. This study aims to assess the most common predictors of uncontrolled blood pressure, which involved elders with hypertension. The method used is a Literature Review obtained from databases of Scopus, Science Direct, PMC, and SAGE. The result revealed that the most common predictor that modifiable is obesity, whereas unmodifiable factors are age and comorbid. It is indicated that the require intervention for hypertensive elder is focused on body weight and comorbid management. This literature review result is beneficial for the elderly of knowing the needs of lifestyle changes and nurse also easier to determine the appropriate intervention to achieve blood pressure control among elders. INDEX TERMS Predictor, uncontrolled, blood pressure, hypertension, elder.

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“…It promotes the emergence of medication-related problems (MRP) [ 10 ]. Potentially inappropriate medications (PIMs) are medications whose adverse risk exceed their health benefits when prescribed in older adults [ 11 ]. They are associated with adverse clinical outcomes such as falls and risk of frailty in the elderly and can lead to higher utilization of healthcare resources and hospital admissions [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

A combination of Beers and STOPP criteria better detects potentially inappropriate medications use among older hospitalized patients with chronic diseases and polypharmacy: a multicenter cross-sectional study

et al. 2023

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Background Research on potentially inappropriate medications (PIM) and medication-related problems (MRP) among the Chinese population with chronic diseases and polypharmacy is insufficient. Objectives This study aimed to investigate the prevalence of PIM and MRP among older Chinese hospitalized patients with chronic diseases and polypharmacy and analyze the associated factors. Methods A retrospective cross-sectional study was conducted in five tertiary hospitals in Beijing. Patients aged ≥ 65 years with at least one chronic disease and taking at least five or more medications were included. Data were extracted from the hospitals’ electronic medical record systems. PIM was evaluated according to the 2015 Beers criteria and the 2014 Screening Tool of Older Persons’ Prescriptions (STOPP) criteria. MRPs were assessed and classified according to the Helper-Strand classification system. The prevalence of PIM and MRP and related factors were analyzed. Results A total of 852 cases were included. The prevalence of PIM was 85.3% and 59.7% based on the Beers criteria and the STOPP criteria. A total of 456 MRPs occurred in 247 patients. The most prevalent MRP categories were dosages that were too low and unnecessary medication therapies. Hyperpolypharmacy (taking ≥ 10 drugs) (odds ratio OR 3.736, 95% confidence interval CI 1.541–9.058, P = 0.004) and suffering from coronary heart disease (OR 2.620, 95%CI 1.090–6.297, P = 0.031) were the influencing factors of inappropriate prescribing (the presence of either PIM or MRP in a patient). Conclusion PIM and MRP were prevalent in older patients with chronic disease and polypharmacy in Chinese hospitals. More interventions are urgently needed to reduce PIM use and improve the quality of drug therapies.

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Potentially Inappropriate Medications Use among Older Adults with Comorbid Diabetes and Hypertension in an Ambulatory Care Setting

Cited by 9 publications

References 33 publications

Prevalence of Use of Potentially Inappropriate Medications Among Older Adults Worldwide

Prevalence of Use of Potentially Inappropriate Medications Among Older Adults Worldwide

The Most Common Predictors of Uncontrolled Blood Pressure Among Hypertensive Elders: A Systematic Review

A combination of Beers and STOPP criteria better detects potentially inappropriate medications use among older hospitalized patients with chronic diseases and polypharmacy: a multicenter cross-sectional study

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