Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients

Durmuş, Nurdan Şentürk; Çinçin, Aslı Tufan; Can, Büşra; Yıldızeli, Şehnaz Olgun; Kocakaya, Derya; İlhan, Birkan; Bahat, Gülistan

doi:10.1590/1806-9282.20220907

Cited by 3 publications

(1 citation statement)

References 20 publications

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“…In a recent study by Durmus et al , an investigation into the relationship between PIM and in-hospital mortality among older adults with COVID-19 did not identify a significant link. 56 Notably, their study’s limited scope as a single-centre cross-sectional study may have restricted its generalisability. In contrast, our study relies on a propensity score-matched nationwide cohort, enhancing its representativeness.…”

Section: Discussionmentioning

confidence: 99%

Potentially inappropriate medication as a predictor of poor prognosis of COVID-19 in older adults: a South Korean nationwide cohort study

Kim,

Hong

2024

BMJ Open

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ObjectivesTo investigate the association between exposure to potentially inappropriate medication (PIM) and poor prognosis of COVID-19 in older adults, controlling for comorbidity and sociodemographic factors.Design and settingNationwide retrospective cohort study based on the national registry of COVID-19 patients, established through the linkage of South Korea’s national insurance claims database with the Korea Disease Control and Prevention Agency registry of patients with COVID-19, up to 31 July 2020.ParticipantsA total of 2217 COVID-19 patients over 60 years of age who tested positive between 20 January 2022 and 4 June 2020. Exposure to PIM was defined based on any prescription record of PIM during the 30 days prior to the date of testing positive for COVID-19.Primary outcome measuresMortality and utilisation of critical care from the date of testing positive until the end of isolation.ResultsAmong the 2217 COVID-19 patients over 60 years of age, 604 were exposed to PIM prior to infection. In the matched cohort of 583 pairs, PIM-exposed individuals exhibited higher rates of mortality (19.7% vs 9.8%, p<0.0001) and critical care utilisation (13.4% vs 8.9%, p=0.0156) compared with non-exposed individuals. The temporal association of PIM exposure with mortality was significant across all age groups (RR=1.68, 95% CI: 1.23~2.24), and a similar trend was observed for critical care utilisation (RR: 1.75, 95% CI: 1.26~2.39). The risk of mortality and critical care utilisation increased with exposure to a higher number of PIMs in terms of active pharmaceutical ingredients and drug categories.ConclusionExposure to PIM exacerbates the poor outcomes of older patients with COVID-19 who are already at high risk. Effective interventions are urgently needed to address PIM exposure and improve health outcomes in this vulnerable population.

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Section: Discussionmentioning

confidence: 99%

Potentially inappropriate medication as a predictor of poor prognosis of COVID-19 in older adults: a South Korean nationwide cohort study

Kim,

Hong

2024

BMJ Open

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Screening Oropharyngeal Dysphagia in Older Adults

Şentürk Durmuş,

Can,

Alkaç

et al. 2024

Topics in Clinical Nutrition

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This study investigated the use of the Eating Assessment Tool 10 (EAT-10) in predicting clinical outcomes in older adults hospitalized with COVID-19 infections between February and June 2021. The EAT-10 was performed for all patients. Thirty one percent and 23% of the 153 patients had oropharyngeal dysphagia risk and in-hospital mortality, respectively. Older age (hazard ratio: 1.08; 95% confidence interval, 1.03-1.13; P = .003) and higher EAT-10 score (hazard ratio: 1.02; 95% confidence interval, 1.01-1.04; P = .043) were associated with in-hospital mortality. Older age and having increased risk of oropharyngeal dysphagia were independently associated with a higher risk of in-hospital mortality in older patients with COVID-19.

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Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatients

Chen,

Tian,

Zeng

2023

BMC Geriatr

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Objectives The purpose of this study was to assess the impact of polypharmacy, potentially inappropriate medications, and drug-drug interactions on in-hospital mortality in older COVID-19 inpatients. Methods A cross-sectional study was conducted using electronic medical data from a tertiary hospital in Chengdu from December 2022 to January 2023. The 2019 AGS/Beers criteria was used to evaluate the potentially inappropriate mediation (PIM) status of older COVID-19 inpatients (age ≥ 65 years), the drug-drug interactions were evaluated on Medscape, and multivariate logistic regression was used to identify the risk factors associated with in-hospital mortality. Results A total of 206 older COVID-19 inpatients were included in the study. The mean number of drugs per day was 13.04. The prevalence of PIM use based on the 2019 AGS Beers Criteria was 66.99%. The prevalence of drug-drug interactions was 61.65%. Logistic regression demonstrated that age ≥ 80 (OR: 10.321, 95% CI: 1.649, 64.579, P = 0.013), renal insufficiency (OR: 4.740, 95% CI: 1.366, 16.447, P = 0.014), long-term hospitalization (OR: 6.637, 95% CI: 1.030, 42.779, P = 0.046), severe pneumonia (OR: 50.230, 95% CI: 5.180, 487.041, P = 0.001) were influencing factors associated with in-hospital mortality in older COVID-19 inpatients. Conclusions The polypharmacy, potentially inappropriate medications, and drug-drug interactions were seen in many older COVID-19 inpatients.

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Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients

Cited by 3 publications

References 20 publications

Potentially inappropriate medication as a predictor of poor prognosis of COVID-19 in older adults: a South Korean nationwide cohort study

Potentially inappropriate medication as a predictor of poor prognosis of COVID-19 in older adults: a South Korean nationwide cohort study

Screening Oropharyngeal Dysphagia in Older Adults

Polypharmacy, potentially inappropriate medications, and drug-drug interactions in older COVID-19 inpatients

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