Potentially Effective and Safe Anti-Helicobacter pylori Natural Products: Chemometric Study

Abstract

<jats:p> The susceptibility of Helicobacter pylori to three essential oils (EOs), 12 naturally occurring monoterpene hydrocarbons, oxygenated and phenolic monoterpenes and three reference antibiotics were studied. Classification and comparison of essential oils and monoterpenes on the basis of their chemical composition and antibacterial activity were made by the utilization of principal component analyses (PCA) and agglomerative hierarchical clustering (AHC). The most abundant compound in the Thymus glabrescens Willd. and Thymus pulegioides L. EOs is geraniol (33.8% and 52.5%), while the main constituent in Satureja kitaibelii Wierzb. ex Heuff. EO is limonene (16,1%). The compound that was the most active against H. pylori was carvacrol. EOs of T. glabrescens and S. kitaibelii exhibit higher antibacterial ability in comparison with all monoterpenes, except carvacrol, probably based on the concept of synergistic activity of essential oil components. PCA separated essential oils based on chemical composition and explain 96.5% of the total variance in the first two principal components. Essential oils, phenolic monoterpenes and two antibiotics were classified in the same sub-cluster within AHC analyses. EOs of T. glabrescens and S. kitaibelii can be used to treat infections caused by H. pylori, as a potentially effective, cheap and safe natural products. Further research of antibacterial activity of selected monoterpenes, essential oils and standard antibiotic combinations, as well as clinical study are required. </jats:p>

GC-MS Profiling, Anti-Helicobacter pylori, and Anti-Inflammatory Activities of Three Apiaceous Fruits’ Essential Oils

“…Phytochemicals, which are good for human health and may even help in preventing diseases, are mainly found in plants. Herbal drugs and their essential oils are known to possess a wide range of pharmacological activities [ 20 , 37 , 38 ]. For thousands of years, essential oils had been used as antibacterial and anti-inflammatory agents [ 39 ].…”

Perspectives on the enhancement of commercially available antibiotics by natural products

“…Limonene and other essential oils, as in Table 1, may be obtained by green extraction methods, they evaporate with time, and they can be detected by electronic noses, which can facilitate quality control in the food industry. Other type of components could be also included in antimicrobial formulations or in the design of plastic polymers that allow for virulence factors modulation [15, 165, 89, 121, 166, 148].…”