Potentially carcinogenic effects of hydrogen peroxide for tooth bleaching on the oral mucosa: A systematic review and meta-analysis

Silveira, Felipe Martins; Schuch, Lauren Frenzel; Schimidt, Tuany Rafaeli; Lopes, Marina Paparotto; Wagner, Vivian Petersen; Só, Bruna Barcelos; Palo, Renato Miotto; Martins, Manoela Domingues

doi:10.1016/j.prosdent.2022.02.001

Cited by 3 publications

(2 citation statements)

References 43 publications

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“…These limitations make the outcomes of these studies difficult to interpret or translate as to whether there is a carcinogenic potential for hydrogen peroxide in animals. Moreover, a recent systematic review and meta‐analysis reported that there is no current evidence that hydrogen peroxide has a carcinogenic effect on the oral mucosa 145 …”

Section: Adverse Effects Of Bleachingmentioning

confidence: 99%

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Intracoronal tooth bleaching – A review and treatment guidelines

Amer

2023

Australian Dental Journal

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Intracoronal bleaching is a minimally invasive procedure that was introduced into dentistry in the 19th century. The role of that procedure in enhancing the colour of teeth subjected to internal discolouration while being conservative made it extremely popular amongst dental professionals. Different materials and techniques have been utilized over the years attempting to obtain predictable long‐term results while minimizing any associated risks. Contemporarily, bleaching agents are mainly based on peroxide‐releasing compounds in different formulations and delivery systems. Different theories have been formulated on the bleaching mechanism of such agents, but the exact mechanism is yet to be proven. The effect of hydrogen peroxide‐based bleaching agents on the organic structure of enamel and dentine has been extensively investigated to address the effects of bonding of resin‐based restorative materials to hard tooth structure. Multiple case reports raised a concern about the contribution of intracoronal bleaching in developing invasive root resorption. Modification of intracoronal bleaching techniques was thus necessary to address such concerns. This review will provide a summary of the important aspects of intracoronal bleaching, focusing on how it applies to the contemporary clinical setting. © 2023 Australian Dental Association.

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Section: Adverse Effects Of Bleachingmentioning

confidence: 99%

“…Moreover, a recent systematic review and meta-analysis reported that there is no current evidence that hydrogen peroxide has a carcinogenic effect on the oral mucosa. 145…”

Section: Carcinogenic Potentialmentioning

confidence: 99%

Intracoronal tooth bleaching – A review and treatment guidelines

Amer

2023

Australian Dental Journal

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Bleaching effectiveness and cytotoxicity of new experimental formulation of niobium-based bleaching gel

et al. 2023

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New Insights Regarding the Use of Relevant Synthetic Compounds in Dentistry

Dumitrel,

Matichescu,

Dinu

et al. 2024

Molecules

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Worldwide, synthetic compounds are used for both in-office and at-home dental care. They are a valuable resource for both prophylactic and curative treatments for various dental problems, such as tooth decay, periodontal diseases, and many more. They are typically preferred due to their broad range of actions and ability to produce targeted, rapid, and long-lasting effects. Using a 0.12% chlorhexidine mouthwash is capable of reducing the plaque index from 47.69% to 2.37% and the bleeding index from 32.93% to 6.28% after just 2 weeks. Mouthwash with 0.1% OCT is also highly effective, as it significantly lowered the median plaque index and salivary bacterial counts in 152 patients in 5 days compared to a control group (p < 0.0001), while also reducing the gingival index (p < 0.001). When povidone-iodine was used as an irrigant during the surgical removal of mandibular third molars in 105 patients, it resulted in notably lower pain scores after 2 days compared to a control group (4.57 ± 0.60 vs. 5.71 ± 0.45). Sodium hypochlorite is excellent for root canal disinfection, as irrigating with 1% NaOCl completely eliminated the bacteria from canals in 65% patients. A 0.05% CPC mouthwash proved effective for perioperative patient care, significantly decreasing gingival bleeding (p < 0.001) and suppressing Streptococcus levels even one week post-surgery. Lastly, a 6% H2O2 paint-on varnish and 6% H2O2 tray formulations successfully bleached the teeth of 40 patients, maintaining a noticeably whiter appearance up to the 6-month follow-up, with significant color differences from the baseline (p < 0.005). Synthetic compounds have a large research base, which also provides a greater awareness of their mechanism of action and potential adverse effects. For a better understanding of how they work, several methods and assays are performed. These are protocolary techniques through which a compound’s efficacy and toxicity are established.

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Potentially carcinogenic effects of hydrogen peroxide for tooth bleaching on the oral mucosa: A systematic review and meta-analysis

Cited by 3 publications

References 43 publications

Intracoronal tooth bleaching – A review and treatment guidelines

Intracoronal tooth bleaching – A review and treatment guidelines

Bleaching effectiveness and cytotoxicity of new experimental formulation of niobium-based bleaching gel

New Insights Regarding the Use of Relevant Synthetic Compounds in Dentistry

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