Potentiality of Melittin-Loaded Niosomal Vesicles Against Vancomycin-Intermediate Staphylococcus aureus and Staphylococcal Skin Infection

Sangboonruang, Sirikwan; Semakul, Natthawat; Obeid, Mohammad A.; Ruano, Marta; Kitidee, Kuntida; Anukool, Usanee; Pringproa, Kidsadagon; Chantawannakul, Panuwan; Ferro, Valerie A.; Tragoolpua, Yingmanee; Tragoolpua, Khajornsak

doi:10.2147/ijn.s325901

Cited by 25 publications

(26 citation statements)

References 81 publications

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“…These results show that the surfactants used here are relatively not toxic and these nanoparticles can be used safely to encapsulate and improve the kinetic profile of atenolol. This was comparable with the cytotoxicity results reported in the literature for other niosomes ( Obeid et al, 2021b ; Gebril et al, 2022 ; Sangboonruang et al, 2021 ). For example, in the work of Hajizadeh et al , niosome prepared by film hydration technique with Span 40: Tween 40: cholesterol at molar ratio of 35:35:30 was shown to have low toxicity and good safety for healthy cells ( Hajizadeh et al, 2019 ).…”

Section: Resultssupporting

confidence: 92%

Characterisation of niosome nanoparticles prepared by microfluidic mixing for drug delivery

Obeid¹,

Khadra²,

Aljabali³

et al. 2022

International Journal of Pharmaceutics: X

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Section: Resultssupporting

confidence: 92%

Characterisation of niosome nanoparticles prepared by microfluidic mixing for drug delivery

Obeid¹,

Khadra²,

Aljabali³

et al. 2022

International Journal of Pharmaceutics: X

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“…As there is no exposure to microwave radiation after formulation, and given the low exposure time (1min), it is likely that this effect would be temporary. This could easily be determined in future work, by examining the relative release rates of a fluorescent molecule such as carboxyfluorescein from formulations prepared with the MW method and other described methods in the literature such as the heating method which has previously been used in such studies [36][37][38]. The increased permeability of the vesicle on exposure to microwave radiation may actually be beneficial in the formulation process, as it could reasonably be expected that this would work in both directions.…”

Section: Discussionmentioning

confidence: 99%

Mucosal and systemic immune responses following mucosal immunisation of tetanus toxoid entrapped in lipid nanoparticles prepared by microwave reactor

Gebril¹,

Obeid²,

Bennett³

et al. 2022

European Journal of Pharmaceutics and Biopharmaceutics

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“…A negative charge causes electrostatic repulsion between particles, resulting in greater formulation stability [ 63 ]. However, the stability of particles strongly depended on Span 60 because highly negatively charged Span 60-containing niosomes bind many proteins, resulting in particle precipitation [ 64 ]. Therefore, a nonexcessive negative charge is suitable for niosome preparation.…”

Section: Resultsmentioning

confidence: 99%

Development of Nanoemulsions for Wound Dressings Containing Cassia alata L. Leaf Extraction

Sangkaew

Wanmasae

Bunluepeuch

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Natural polymer-based hydrogel films possess considerable potential for use in biomedical applications and are excellent for wound healing. The purpose of this research was to use ionic crosslinking to improve the mechanical characteristics, absorption of fluid in the wound, and drug release behavior of Cassia alata L. (CA) extract loaded niosomes (CANs) that were incorporated in an alginate-pectin film (A/P). Then, chemically crosslinked A/P hydrogels were obtained by immersing them in different concentrations of calcium chloride (CaCl2) (0.5–1% w/v) for 15–120 s. The degree of crosslinking was controlled by both contact time and CaCl2 concentration. The optimal crosslinking conditions were 1% CaCl2 for 15 seconds. In this study, the following features of the hydrogel films were investigated: physical properties, morphological characteristics, drug loading, in vitro drug release, antibacterial activity, wound healing activity, cytocompatibility profiles, and hemocompatibility. The crosslinked hydrogel films maintained their physical integrity during use, with the 1% film attaining the best results in the shortest period (15 sec). Then, in vitro drug release from the films was examined. Crosslinking was observed to prolong the release of the CA extract from the hydrogel film. Finally, a cell viability experiment was conducted to evaluate the cytotoxicity profile. The A/P composite film exhibited excellent wound dressing qualities and good mechanical properties in preformulation testing. The in vitro drug release profile indicated that the A/P created a regulated drug release profile, and the cell viability experiment revealed that the film was nontoxic and hemocompatible. A/P composite films can be produced using CAN extract as a possible wound dressing. However, further studies in animals and humans are required to determine both safety and effectiveness.

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Potentiality of Melittin-Loaded Niosomal Vesicles Against Vancomycin-Intermediate Staphylococcus aureus and Staphylococcal Skin Infection

Cited by 25 publications

References 81 publications

Characterisation of niosome nanoparticles prepared by microfluidic mixing for drug delivery

Characterisation of niosome nanoparticles prepared by microfluidic mixing for drug delivery

Mucosal and systemic immune responses following mucosal immunisation of tetanus toxoid entrapped in lipid nanoparticles prepared by microwave reactor

Development of Nanoemulsions for Wound Dressings Containing Cassia alata L. Leaf Extraction

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