Potentialities of the Lymphocyte, With an Additional Reference to Its Dysfunction in Hodgkin's Disease

Skin Window Cellularity and Macrophage Changes in Hodgkin’s and Non-Hodgkin’s Lymphomas

“…Although the earlier literature is somewhat conflicting [7][8][9], a reduction in cellularity has previously been described in treated cases of Hodgkin's disease [7]. In the pres ent investigation, however, none of the pa tients with Hodgkin's disease had received treatment and although 7 out of the 20 pa tients with non-Hodgkin's lymphoma were treated, a highly significant depression of cellularity could still be observed when only the untreated cases were considered.…”

Histochemical Studies of Leukocytes from an Inflammatory Exudate

“…In this connection it is interesting that the alkaline phosphatase and phosphorylase activity of blood neutrophils varies under pathological conditions (3,16,21), whereas for instance esterase activity, record ed by the naphthol AS-D chloroacetate method, presents no such changes (4). The alkaline phosphatase activity in neutrophils from "skin windows" has previously been studied by R ebuck et al and P e r il l ie and F in c h , who found that the activity in migrating neutrophils varies with that of blood neutrophils under pathological conditions (9,12,13).…”

“…and later R ebuck ct al. used Wulff, Histochemical Studies of Leukocytes from an X X X /1963 the same method for the staining of "skin window" preparations (12). The technique, however, is unsatisfactory as the results are difficult to interpret due to marked diffusion of the reaction product.…”

Quantitative Studies of Macrophages in Blood Cultures in Hodgkin’s Disease

“…In skin window preparations in Hodgkin's disease, Rebuck et al [15] re ported a reduction of the overall cellularity, whilst, using a similar tech nique, G hosh et al [7] found a copious cellular migration (over 90% of the cells being macrophages) either in normal subjects and in Hodgkin's disease.…”