Potential Usefulness of Inflammatory Markers to Monitor Respiratory Functional Impairment in Sarcoidosis

S, Kos; Dieijen-Visser, Marja P. van; Mulder, Paul; Drent, Marjolein

doi:10.1373/49.9.1510

Cited by 140 publications

(114 citation statements)

References 31 publications

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“…As sarcoidosis is an inflammatory disease, it has been expected to observe increased values of hsCRP, ACE (11,12) and SAA compared to controls (13,14) and our results were in agreement with these findings (Table I). Increased concentrations of SAA may be a consequence of either increased production of proinflammatory cytokines that stimulate hepatic production of SAA (11) or activated cells in granulomas that also produce SAA (15).…”

Section: Discussionsupporting

confidence: 92%

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Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients

Ivanišević¹,

Stefanović²,

Kotur‐Stevuljević³

et al. 2017

Arh farmaciju

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SummaryMatrix metaloproteinases (MMPs) and their specific inhibitors -tissue inhibitors of matrix metalloproteinases (TIMPs) play an important role in pulmonary extracellular matrix destruction. Sarcoidosis is an inflammatory disease affecting multiple organs. It has been reported that MMP-9 and TIMP-1 levels were increased in bronchoalveolar lavage fluid and induced sputum of sarcoidosis patients. The aim of our study was to evaluate MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations and MMP-9/TIMP-1 ratio in sarcoidosis patients, their relationship with inflammatory markers and their ability do predict the existence of disease. We included 101 sarcoidosis patients and 50 healthy subjects. Serum samples were analyzed. Besides routine biochemical parameters, high-sensitive C-reactive protein (hsCRP), serum amyloid A (SAA), MMP-9, TIMP-1 and MMP-9/TIMP-1 complex concentrations were measured. MMP-9 (P<0.05), hsCRP, SAA and TIMP-1 (P<0.001) concentrations were significantly increased in patients whereas MMP-9/TIMP-1 complex was higher in patients, but with marginal significance. In sarcoidosis, TIMP-1 correlated significantly positively with inflammatory parameters (P<0.05). Uni-variate analysis showed that MMP-9, TIMP-1, hsCRP and SAA had the ability to predict the existence of sarcoidosis. In the model consisted of MMP-9, TIMP-1, hsCRP and SAA, only SAA remained significant predictor of disease (P<0.01). Results showed the significance of MMP-9 and TIMP-1 in sarcoidosis.

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Section: Discussionsupporting

confidence: 92%

“…Increased concentrations of SAA may be a consequence of either increased production of proinflammatory cytokines that stimulate hepatic production of SAA (11) or activated cells in granulomas that also produce SAA (15).…”

Section: Discussionmentioning

confidence: 99%

Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients

Ivanišević¹,

Stefanović²,

Kotur‐Stevuljević³

et al. 2017

Arh farmaciju

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“…Similarly to neopterin, it was elevated in progressive rather than in stable disease or patients with Löfgren syndrome (Ziegenhagen et al, 2003). It was shown to be the most reliable activity marker when compared with hsCRP (hs for high sensitivity), SACE and SAA (Rothkrantz-Kos et al, 2003). The same authors reported that only 7 of 31 untreated patients with low sIL2R values, but 8 of 11 with high sIL2R values needed treatment in follow-up observation (meaning that 73 % of patients with high values, but only 23% of patients with low sIL2R had less favorable outcome).…”

Section: Other Immunological Markersmentioning

confidence: 96%

“…Serum amyloid A (SAA) is another acute phase reactant which is related to HDL-cholesterol. Its diagnostic value in sarcoidosis is similar to CRP (Rothkrantz-Kos et al, 2003), but recent data show its potential role in the pathogenesis of sarcoidosis, as it was shown to be deposited in granuloma cells. This molecule is capable of triggering the release of cytokines through an interaction with toll-like receptor 2 (Chen et al, 2010).…”

Section: Acute Phase Reactantsmentioning

confidence: 97%

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Prognostic Factors in Sarcoidosis

Piotrowski¹

2011

Sarcoidosis Diagnosis and Management

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Paraoxonase 1 and atherosclerosis‐related diseases

et al. 2019

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A direct and an indirect relationship between paraoxonase 1 (PON1) and atherosclerosis exists. Given PON1's physical location within high‐density lipoprotein (HDL) particles and its recognized enzyme activity, it is certainly reasonable to suggest that PON1 facilitates the antiatherogenic nature of HDL particles. PON1 also plays a role in regulating reverse cholesterol transport, antioxidative, anti‐inflammatory, antiapoptotic, vasodilative, and antithrombotic activities and several endothelial cell functions. HDL dysfunctionality is a more recent issue and seems to be centered on pathological conditions affecting HDL structure and size profiles. This review is focused on the role of PON1 status in different atherosclerosis‐related diseases that we have studied over the last twenty years (coronary heart disease, acute ischemic stroke, diabetes mellitus type 2, end‐stage renal disease, chronic obstructive pulmonary disease, and sarcoidosis) with the aim to determine the true value of PON1 as a biomarker. The role of PON1 in cancer is also covered, as risk factors and mechanisms underlying both atherosclerosis and cancer share common features.

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Potential Usefulness of Inflammatory Markers to Monitor Respiratory Functional Impairment in Sarcoidosis

Abstract: Background: Sarcoidosis is a multiorgan inflammatory granulomatous disorder of unknown origin for which adequate markers to monitor disease severity are lacking. The aim of this study was to evaluate the potential clinical usefulness of serologic markers of inflammation

Cited by 140 publications

References 31 publications

Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients

Matrix metalloproteinases-9 and tissue inhibitor of matrix metalloproteinases-1 in sarcoidosis patients

Prognostic Factors in Sarcoidosis

Paraoxonase 1 and atherosclerosis‐related diseases

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