Potential Use of Tailored Citicoline Chitosan-Coated Liposomes for Effective Wound Healing in Diabetic Rat Model

Eid, Hussein M.; Ali, Adel A.; Ali, Ahmed Mahmoud Abdelhaleem; Eissa, Dalia Essam; Hassan, Randa M.; El-Ela, Fatma I. Abo; Hassan, Amira H.

doi:10.2147/ijn.s342504

Cited by 28 publications

(27 citation statements)

References 60 publications

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“…Using the plot3D package in R software, 3D surface graphs are plotted [ 24 , 25 ]. The optimization was set to minimum size and maximum surface charge and entrapment to obtain the formula with the maximum desirability [ 26 , 27 ].…”

Section: Methodsmentioning

confidence: 99%

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Intranasal Delivery of Granisetron to the Brain via Nanostructured Cubosomes-Based In Situ Gel for Improved Management of Chemotherapy-Induced Emesis

et al. 2022

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This research aimed to boost granisetron (GS) delivery to the brain via the intranasal route to better manage chemotherapy-induced emesis. Glycerol monooleate (GMO), Poloxamer 407 (P 407) and Tween 80 (T 80) were used to formulate GS-loaded cubosomes (GS-CBS) utilizing a melt dispersion-emulsification technique. GS-CBS were characterized by testing particle diameter, surface charge and entrapment efficiency. The formulations were optimized using a Box–Behnken statistical design, and the optimum formula (including GMO with a concentration of 4.9%, P 407 with a concentration of 10%, and T 80 with a concentration of 1%) was investigated for morphology, release behavior, ex vivo permeation through the nasal mucosa, and physical stability. Moreover, the optimal formula was incorporated into a thermosensitive gel and subjected to histopathological and in vivo biodistribution experiments. It demonstrated sustained release characteristics, increased ex vivo permeability and improved physical stability. Moreover, the cubosomal in situ gel was safe and biocompatible when applied to the nasal mucosa. Furthermore, compared to a drug solution, the nose-to-brain pathway enhanced bioavailability and brain distribution. Finally, the cubosomal in situ gel may be a potential nanocarrier for GS delivery to the brain through nose-to-brain pathway.

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Section: Methodsmentioning

confidence: 99%

“…The GS levels in the supernatant portion were estimated spectrometrically at 302 nm. The EE percentage was calculated using the following equation [26,27]: EE% = (GS added (10 mg) − Free GS in supernatant) GS added (10 mg) × 100…”

Section: Measurement Of Entrapment Efficiencymentioning

confidence: 99%

Intranasal Delivery of Granisetron to the Brain via Nanostructured Cubosomes-Based In Situ Gel for Improved Management of Chemotherapy-Induced Emesis

et al. 2022

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“…Recent studies highlighted that modern dressings with natural active compounds or HEs can be an ideal delivery system in wound healing [ 115 , 116 ]. In addition, other studies describing the incorporation of lipid vesicles in modern dressings for wound healing have shown promising results [ 117 , 118 , 119 , 120 ]. Although, a thorough search of the relevant literature yielded only a limited number of studies in which VNs with PCs were included in polymeric dressings for wound healing [ 31 , 94 ].…”

Section: Topical Delivery Systems Containing Herbal Extractsmentioning

confidence: 99%

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

2022

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The need to develop wound healing preparations is a pressing challenge given the limitations of the current treatment and the rising prevalence of impaired healing wounds. Although herbal extracts have been used for many years to treat skin disorders, due to their wound healing, anti-inflammatory, antimicrobial, and antioxidant effects, their efficacy can be questionable because of their poor bioavailability and stability issues. Nanotechnology offers an opportunity to revolutionize wound healing therapies by including herbal compounds in nanosystems. Particularly, vesicular nanosystems exhibit beneficial properties, such as biocompatibility, targeted and sustained delivery capacity, and increased phytocompounds’ bioavailability and protection, conferring them a great potential for future applications in wound care. This review summarizes the beneficial effects of phytocompounds in wound healing and emphasizes the advantages of their entrapment in vesicular nanosystems. Different types of lipid nanocarriers are presented (liposomes, niosomes, transferosomes, ethosomes, cubosomes, and their derivates’ systems), highlighting their applications as carriers for phytocompounds in wound care, with the presentation of the state-of-art in this field. The methods of preparation, characterization, and evaluation are also described, underlining the properties that ensure good in vitro and in vivo performance. Finally, future directions of topical systems in which vesicle-bearing herbal extracts or phytocompounds can be incorporated are pointed out, as their development is emerging as a promising strategy.

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“…Chitosan (CTS), produced via the partial deacetylation of chitin, is a cationic amino polysaccharide obtained from squid pens, crustacean exoskeletons, and fungi [ 22 ]. CTS recently received much attention due to its unique attributes, such as its polycationic character, biocompatibility, in vivo biodegradability, mucoadhesiveness, and solubility at a low pH in an aqueous medium, wound healing, and antibacterial activity [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…The coating process is often facilitated by electrostatic interaction between the negative surface charge of the nanovesicles and the amino-acid-positive group of CTS [ 25 ]. The surface coating of nanovesicles by CTS has various benefits, such as boosting stability, prolonging drug release, increasing cellular absorption, and preventing drug leakage [ 22 ]. In the TDS area, CTS is attracting considerable interest, and several studies have suggested utilizing CTS as a strategy to improve TDS [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Surface-Modified Bilosomes Nanogel Bearing a Natural Plant Alkaloid for Safe Management of Rheumatoid Arthritis Inflammation

et al. 2022

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Rheumatoid arthritis (RA) is a chronic inflammatory illness affecting the joints. The characteristic of RA is gradual joint deterioration. Current RA treatment alleviates signs such as inflammation and pain and substantially slows the progression of the disease. In this study, we aimed to boost the transdermal delivery of berberine (a natural product) by encapsulating it in chitosan, surface-modified bilosomes nanogel for better management of the inflammation of RA. The chitosan-coated bilosomes loaded with berberine (BER-CTS-BLS) were formulated according to the thin-film hydration approach and optimized for various causal variables, considering the effect of lipid, sodium deoxycholate, and chitosan concentrations on the size of the particles, entrapment, and the surface charge. The optimized BER-CTS-BLS has 202.3 nm mean diameter, 83.8% entrapment, and 30.8 mV surface charge. The optimized BER-CTS-BLS exhibited a delayed-release profile in vitro and increased skin permeability ex vivo. Additionally, histological examination revealed that the formulated BLS had no irritating effects on the skin. Furthermore, the optimized BER-CTS-BLS ability to reduce inflammation was evaluated in rats with carrageenan-induced paw edema. Our results demonstrate that the group treated with topical BER-CTS-BLS gel exhibited a dramatic reduction in rat paw edema swelling percentage to reach 24.4% after 12 h, which was substantially lower than other groups. Collectively, chitosan-coated bilosomes containing berberine have emerged as a promising therapeutic approach to control RA inflammation.

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Potential Use of Tailored Citicoline Chitosan-Coated Liposomes for Effective Wound Healing in Diabetic Rat Model

Cited by 28 publications

References 60 publications

Intranasal Delivery of Granisetron to the Brain via Nanostructured Cubosomes-Based In Situ Gel for Improved Management of Chemotherapy-Induced Emesis

Intranasal Delivery of Granisetron to the Brain via Nanostructured Cubosomes-Based In Situ Gel for Improved Management of Chemotherapy-Induced Emesis

Vesicular Nanocarriers for Phytocompounds in Wound Care: Preparation and Characterization

Surface-Modified Bilosomes Nanogel Bearing a Natural Plant Alkaloid for Safe Management of Rheumatoid Arthritis Inflammation

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