Potential use of hematological and acute phase protein parameters in the diagnosis of acute Schmallenberg virus infection in experimentally infected calves

Kęsik-Maliszewska, Julia; Pomorska‐Mól, Małgorzata; Collins, Áine B.; Rola, J.; Larska, Magdalena

doi:10.1016/j.cimid.2019.03.008

Cited by 5 publications

(4 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparing to our study, the European bisons from HEAL were below this value (0.176 mg/ml), while the animals from ELIM were above the cut-off point (0.305 mg/ml). Yet, Kęsik-Maliszewska et al [ 29 ] have not proved differences in serum APPs excretion in experimentally infected with Schmallenberg virus calves, suggesting that not all infections induce measurable response. A team of Ansari-Lari et al [ 30 ] analysed changes of Hp, Fb, SAA and albumin (Ab) levels in the course of post-traumatic reticulitis and peritonitis in cattle.…”

Section: Discussionmentioning

confidence: 99%

Acute-phase protein concentrations in serum of clinically healthy and diseased European bison (Bison bonasus) – preliminary study

et al. 2022

Self Cite

View full text Add to dashboard Cite

Background This is the first report describing levels of APPs in European bison. Serum concentration of acute phase proteins (APPs) may be helpful to assess general health status in wildlife and potentially useful in selecting animals for elimination. Since there is a lack of literature data regarding concentration of APPs in European bisons, establishment of the reference values is also needed. Methods A total of 87 European bison from Polish populations were divided into two groups: (1) healthy: immobilized for transportation, placing a telemetry collar and routine diagnostic purposes; and (2) selectively culled due to the poor health condition. The serum concentration of haptoglobin, serum amyloid A and α1-acid-glycoprotein were determined using commercial quantitative ELISA assays. Since none of the variables met the normality assumptions, non-parametric Mann-Whitney U test was used for all comparisons. Statistical significance was set at p < 0.05. Statistical analyses were performed using Statistica 13.3 (Tibco, USA). Results The concentration of haptoglobin and serum amyloid A was significantly higher in animals culled (euthanised) due to the poor condition in respect to the clinically healthy European bison. The levels of α1-acid-glycoprotein did not show statistical difference between healthy and sick animals. Conclusions Correlation between APPs concertation and health status was proven, therefore the determination of selected APPs may be considered in future as auxiliary predictive tool in assessing European bison health condition.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute-phase protein concentrations in serum of clinically healthy and diseased European bison (Bison bonasus) – preliminary study

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…However, although the levels of both proteins increased during infection, the pattern of response was different when analyzing the different clinical stages and pathological forms of PTB. In most of the conditions evaluated in ruminants, the increase in the APPs’ levels was proportional to the severity of the lesions and clinical signs [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. In the case of mycobacterial diseases, studies carried out in tuberculous animals also showed increases in serum APPs according to the severity of the lesions present [ 29 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…The circulating concentration of these APPs is related to the severity of the disorder and the extent of tissue damage in the affected animal, therefore giving not only diagnostic but even prognostic value [ 17 ]. In this sense, the influence of different inflammatory conditions on the concentrations of these proteins in domestic livestock has been documented, such as in various bacterial and metabolic disorders such as metritis [ 18 ], mastitis [ 19 ], caseous lymphadenitis [ 20 ], respiratory infections [ 21 ], or ruminal acidosis [ 22 ]; parasitic diseases such as psoroptic and sarcoptic mange [ 23 , 24 ];or viral conditions as Schmallenberg virus infection [ 25 ], bovine viral diarrhea [ 26 ], blue tongue disease [ 27 ], or foot-and-mouth disease [ 28 ], among others.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Acute-Phase Protein Response Associated with the Different Pathological Forms of Bovine Paratuberculosis

Espinosa

Morena

Benavides

et al. 2020

Animals

View full text Add to dashboard Cite

In this study, the concentrations of two acute-phase proteins (APPs), haptoglobin (Hp) and serum amyloid A (SAA), were quantitatively assessed in serum samples from cattle naturally infected with paratuberculosis (PTB). APP profiles were compared across 190 animals classified according to the different pathological forms associated with infection: uninfected (n = 59), with focal lesions (n = 73), multifocal lesions (n = 19), and diffuse paucibacillary (n = 11) and diffuse multibacillary lesions (n = 28). Our results showed a significant increase in both APPs in infected animals compared to the control group, with differences depending on the type of lesion. Hp and SAA levels were increased significantly in all infected animals, except in cows with diffuse multibacillary lesions that showed similar values to non-infected animals. The expression pattern of both APPs was similar and negatively correlated with the antibody levels against PTB. These results indicate that the release of Hp and SAA is related to the presence of PTB lesions associated with a high cell-mediated immune response and a lower bacterial load, suggesting that the pro-inflammatory cytokines that are associated with these forms are the main stimulus for their synthesis. These molecules could show some potential to be used as putative biomarkers of PTB infection, particularly for the identification of subclinical animals showing pathological forms related to latency or resistance to the development of advanced lesions.

show abstract

“… [ 2 , 35 ] Schmallenberg virus The mid-size white blood cell (mid) and red blood cell count (RBC) are decreased, while the average red blood cell hemoglobin is increased. [ 51 ] Hepatitis E virus Transaminase and serum bilirubin concentration are significantly increased. [ 52 ] Ebola virus Haematological abnormalities were common, including raised haematocrit thrombocytopenia, and granulocytosis.…”

Section: Detection Methodsmentioning

confidence: 99%

Current methods and prospects of coronavirus detection

Deng

Liu

et al. 2021

Talanta

View full text Add to dashboard Cite

Potential use of hematological and acute phase protein parameters in the diagnosis of acute Schmallenberg virus infection in experimentally infected calves

Cited by 5 publications

References 38 publications

Acute-phase protein concentrations in serum of clinically healthy and diseased European bison (Bison bonasus) – preliminary study

Acute-phase protein concentrations in serum of clinically healthy and diseased European bison (Bison bonasus) – preliminary study

Assessment of Acute-Phase Protein Response Associated with the Different Pathological Forms of Bovine Paratuberculosis

Current methods and prospects of coronavirus detection

Contact Info

Product

Resources

About