Potential use of drug carried-liposomes for cancer therapy via direct intratumoral injection

Bao, Ande; Phillips, William T.; Goins, Beth; Zheng, Xiangpeng; Sabour, Siamak; Natarajan, Mohan; Woolley, F. Ross; Zavaleta, Cristina; Otto, Randal A.

doi:10.1016/j.ijpharm.2006.02.039

Cited by 68 publications

(72 citation statements)

References 16 publications

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“…Previous studies have shown that liposomal systems exhibit broad interstitial diffusion within tumor mass after intratumoral injection, with slow clearance from the interstitial space. 29 Prolonged accumulation of liposomes and the therapeutics within tumor mass does not always lead to enhanced intracellular delivery as it is necessary to establish if binding to the extracellular matrix does not hinder intracellular uptake into tumor cells. In conclusion of this 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 study, carbon nanotubemediated delivery exhibited the highest uptake in tumor cells as obtained by CLSM which conflicts with, conflicting the results obtained by whole body IVIS imaging which showed higher fluorescence signals of tumors injected with the lipoplexes.…”

Section: Discussionmentioning

confidence: 99%

Design of Cationic Multiwalled Carbon Nanotubes as Efficient siRNA Vectors for Lung Cancer Xenograft Eradication

et al. 2015

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PoloLike Kinase (PLK1) has been identified as a potential target in cancer gene therapy via chemical or genetic inhibitory approaches. The biomedical applications of chemically functionalized carbon nanotubes (fCNTs) in cancer therapy have been studied due to their ability to efficiently deliver siRNA intracellularly. In this study, we established the capacity of cationic MWNTNH 3 + to deliver the apoptotic siRNA against PLK1 (siPLK1) by RTPCR and Western blot, in addition to TUNEL staining confirmed the biological functionality of the siRNA intratumorally, suggesting that tumor eradication was due to PLK1 knockdown. Furthermore, by using a fluorescently labeled, noncoding siRNA sequence complexed with MWNTNH 3 + , we established for the first time that the improved therapeutic efficacy observed in f CNTbased siRNA delivery is directly proportional to the enhanced siRNA retention in the solid tumor and subsequent uptake by tumor cells after local administration in vivo.

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Section: Discussionmentioning

confidence: 99%

Design of Cationic Multiwalled Carbon Nanotubes as Efficient siRNA Vectors for Lung Cancer Xenograft Eradication

et al. 2015

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“…58 Also, 186 Re-PEG-liposomes could be used for the treatment of large intact solid tumors or partially resected tumors via intratumoral injection of the therapeutic agent. 46,59,60 The therapeutic effect of 186 Re-Doxil, 186 Re-PEG-liposomes, and intravenous Doxil on tumors is shown by histopathologic examination. Control tumors and 186 Re-liposome-treated tumors showed lobules of tumor cells separated by extracellular matrix.…”

Section: -234748mentioning

confidence: 99%

Chemoradionuclide Therapy with¹⁸⁶Re-Labeled Liposomal Doxorubicin: Toxicity, Dosimetry, and Therapeutic Response

Soundararajan

Bao

Phillips³

et al. 2011

Cancer Biotherapy and Radiopharmaceuticals

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This study was performed to determine the maximum tolerated dose (MTD) and therapeutic effects of rhenium-186 ( 186 Re)-labeled liposomal doxorubicin (Doxil), investigate associated toxicities, and calculate radiation absorbed dose in head and neck tumor xenografts and normal organs. Doxil and control polyethylene glycol (PEG)-liposomes were labeled using Re-Doxil has promising potential, because good tumor control was achieved with limited associated toxicity.

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“…Almond et al (22) reported the in vivo evaluation of the efficacy of an intratumoral injection of mitoxantrone both as a free drug and as drug-loaded albumin microspheres. Finally, Bao et al (23) reported the potential use of liposome drug carriers for cancer therapy via direct intratumoral injection. Higher intratumoral retention of the technetium99m ( 99m Tc)-liposomes was accompanied by improved intratumoral diffusion suggesting that intratumorally administered liposomal drugs are potentially promising agents for solid tumor local therapy.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of tailored, selective and effective anticancer chemotherapy by direct injection of docetaxel-loaded immunoliposomes into Her2/neu positive gastric tumor xenografts

Yamamoto

Yoshida²,

Sato³

et al. 2010

Int J Oncol

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Abstract.We assessed the effects of direct injection of docetaxel-loaded immuno-(trastuzumab)-liposomes (IDL) on a xenograft mouse tumor model to determine potential clinical applications of intratumoral tailored chemotherapy against Her2/neu-overexpressing gastric cancer. The NCI-N87 Her2/neu overexpressing gastric cancer cell line xenograft mouse model was treated with IDL or docetaxel-loaded liposomes (DL). The ratio of the tumor volume of the treatment:control was determined. In addition, docetaxel pharmacokinetics in tumors were measured using highperformance liquid chromatography, and the cell viability and cell cycle distribution of Her2/neu positive cells were determined by flow cytometric analysis. The IDL group showed a significantly higher distribution of docetaxel in the N87 xenograft tumor tissues and superior antitumor efficacy compared to crude administration of docetaxel and/or trastuzumab and DL. The number of viable Her2/neu positive cells decreased following treatment with either free trastuzumab or IDL. On day 7 after treatment, a decrease in the G0/G1 phase of the cell cycle was observed in the DL and IDL groups compared to the control group. No local adverse effects were observed. These results suggest that intratumoral administration of IDL maintains a high concentration of docetaxel within the tumor leading to a safe and effective regional cancer therapeutic strategy. In addition to the inherent cytotoxic effect of trastuzumab, conjugation of trastuzumab to a liposome further enhanced the retention of docetaxel within the tumors. These data suggest that immuno-liposome mediated delivery of drugs is a promising new therapeutic option for patients with advanced gastric cancer that overexpress Her2/neu.

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Potential use of drug carried-liposomes for cancer therapy via direct intratumoral injection

Cited by 68 publications

References 16 publications

Design of Cationic Multiwalled Carbon Nanotubes as Efficient siRNA Vectors for Lung Cancer Xenograft Eradication

Design of Cationic Multiwalled Carbon Nanotubes as Efficient siRNA Vectors for Lung Cancer Xenograft Eradication

Chemoradionuclide Therapy with¹⁸⁶Re-Labeled Liposomal Doxorubicin: Toxicity, Dosimetry, and Therapeutic Response

Feasibility of tailored, selective and effective anticancer chemotherapy by direct injection of docetaxel-loaded immunoliposomes into Her2/neu positive gastric tumor xenografts

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Potential use of drug carried-liposomes for cancer therapy via direct intratumoral injection

Cited by 68 publications

References 16 publications

Design of Cationic Multiwalled Carbon Nanotubes as Efficient siRNA Vectors for Lung Cancer Xenograft Eradication

Design of Cationic Multiwalled Carbon Nanotubes as Efficient siRNA Vectors for Lung Cancer Xenograft Eradication

Chemoradionuclide Therapy with186Re-Labeled Liposomal Doxorubicin: Toxicity, Dosimetry, and Therapeutic Response

Feasibility of tailored, selective and effective anticancer chemotherapy by direct injection of docetaxel-loaded immunoliposomes into Her2/neu positive gastric tumor xenografts

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Chemoradionuclide Therapy with¹⁸⁶Re-Labeled Liposomal Doxorubicin: Toxicity, Dosimetry, and Therapeutic Response