Potential Use of Cyclodextrins as Drug Carriers and Active Pharmaceutical Ingredients

Abstract

Cyclodextrins (CyDs) are extensively used in various fields, and especially have been widely utilized as pharmaceutical excipients and drug carriers in the pharmaceutical field. Owing to the multi-functional and biocompatible characteristics, CyDs can improve the undesirable properties of drug molecules. This review outlines the current application of CyDs in pharmaceutical formulations, focusing on their use as CyD-based drug carriers for several kinds of drugs. Additionally, CyDs have great potential as active pharmaceutical ingredients against various diseases with few side effects.

Supramolecular Pharmaceutical Sciences: A Novel Concept Combining Pharmaceutical Sciences and Supramolecular Chemistry with a Focus on Cyclodextrin-Based Supermolecules

“…CyDs and their derivatives are widely used as pharmaceutical excipients to improve pharmaceutical properties such as stability, solubility, bioavailability, and taste of drugs. 13,14,16) Notably, CyDs have been used as building blocks of supermolecules, [17][18][19][20] as well as crown ethers, 21) cucurbituril, 22) pillar[n] arenes, 23,24) cryptand, 25) and calixarene. 26) Therefore CyDs can play the role of mediators between supramolecular chemistry and pharmaceutical sciences.…”

Inhibitory effects of alpha-cyclodextrin and its derivative against sucrose-induced hyperglycemia in an <i>in vivo</i> evaluation system

“…α-cyclodextrin (α-CyD) is composed of six glucose residues, β-cyclodextrin (β-CyD) of seven glucose residues, and γ-cyclodextrin (γ-CyD) of eight glucose units. CyD derivatives are clinically used for improving drug solubility and drug delivery (13). Moreover, α-, β-, and γ-CyDs have a capacity to inhibit α-amylase or glucoamylase, which degrade starch to maltose (14).…”

Sulfated β‐Cyclodextrin Templated Assembly and Disassembly of Acridine Orange: Unraveling Contrasting Binding Mechanisms and Light Off/On Switching

“…Active research in supramolecular chemistry involving efficient water soluble macrocyclic hosts have aroused immense interest in molecular recognition field due to their potential applications in chemotherapy, drug delivery, pharmaceuticals, imaging, sensors,, on–off switches, food industry,, catalysis,, nanotechnology,, functional materials, etc. Supramolecular host‐guest assemblies constructed through non‐covalent interactions are highly reversible, dynamic and easy to tune by the influence of external stimuli like light, temperature, pH,,,, competitive analyte,,, etc., which provides these assemblies to be amenable for execution of many “on demand” roles at targeted sites and specific sensing .…”

“…In supramolecular chemistry, native and derivatized cyclodextrins (CDs) are the most widely investigated host molecules to explore application prospects related to targeted drug delivery, pharmaceutical formulations, improved bioavailability, efficient nanomedicines, etc ,. and many of these macrocycles are realized as the novel excipients possessing many unexplored potentials.…”