Potential use of C-phycocyanin in non-alcoholic fatty liver disease

Ma, Peng; Huang, Rongrong; Jiang, Jingyao; Yuan, Ding; Li, Tingting; Ou, Yu

doi:10.1016/j.bbrc.2020.04.001

Cited by 18 publications

(11 citation statements)

References 32 publications

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“…The cylinders that are in contact with the membrane have an α subunit replaced by ApcD and a β subunit replaced by ApcF. A second α unit is replaced by the globular domain (PB domain) of the Linker core-membrane (ApcE) [18] , [45] . ApcD, ApcF and PB domain are essential to energy tansfer to the photosystems [46] , [47] , [48] , [49] …”

Section: Structural Characteristics Of Pbpsmentioning

confidence: 99%

“… Nutraceuticals and therapeutics of non-alcoholic fatty liver disease. [45] Spirulina platensis / Inhibits α-amylase and β-glucosidase enzymes activity. Potential drug development for diabetes type 2 treatment.…”

Section: Biotechnological Perspectives Of Pbpsmentioning

confidence: 99%

“…Anti-obesity activity was identified for PC by inhibition of the pancreatic lipase activity [99] . In addition, C-PC reduce the lipid accumulation in the steatosis L02 cells and liver of non-alcoholic steatohepatitis (NASH) mice, and improve the antioxidant capacity of liver [45] .…”

Section: Biotechnological Perspectives Of Pbpsmentioning

confidence: 99%

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Phycobiliproteins: Structural aspects, functional characteristics, and biotechnological perspectives

Dagnino‐Leone

Figueroa

Castañeda

et al. 2022

Computational and Structural Biotechnology Journal

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Section: Structural Characteristics Of Pbpsmentioning

confidence: 99%

Section: Biotechnological Perspectives Of Pbpsmentioning

confidence: 99%

See 1 more Smart Citation

Phycobiliproteins: Structural aspects, functional characteristics, and biotechnological perspectives

Dagnino‐Leone

Figueroa

Castañeda

et al. 2022

Computational and Structural Biotechnology Journal

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“…C-PC, a selective cyclooxygenase-2 inhibitor [ 215 ], limits nitric oxide production, iNOS expression, TNF-α formation and NF-κB activation in lipopolysaccharide-stimulated RAW 264.7 macrophages, thus limiting some key aspects of deregulated inflammation [ 216 ]. Moreover, the administration of either Sp extract, C-PC or PCB has been found to protect the liver under diverse hepatotoxic conditions [ 217 - 220 ]. Given that liver injury is associated with severe disease in COVID-19 patients [ 221 ], and also has an impact on the progression of neurological conditions like encephalopathy [ 222 ], it can be seen that this liver-safeguarding action of C-PC/PCB may provide indirect neuroprotective activity in these patients.…”

Section: C-pc/pcb For the Complementary Management Of Covid-19-induce...mentioning

confidence: 99%

C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19- induced Damage to the Nervous System

Pentón‐Rol

Marín‐Prida

McCarty³

2021

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: The edible cyanobacterium Spirulina platensis and its chief biliprotein C-Phycocyanin have shown protective activity in animal models of diverse human health diseases, often reflecting antioxidant and anti-inflammatory effects. The beneficial effects of C-Phycocyanin seem likely to be primarily attributable to its covalently attached chromophore Phycocyanobilin (PCB). Within cells, biliverdin is generated from free heme and it is subsequently reduced to bilirubin. Although bilirubin can function as an oxidant scavenger, its potent antioxidant activity reflects its ability to inactivate some isoforms of NADPH oxidase. Free bilirubin can also function as an agonist for the aryl hydrocarbon receptor (AhR); this may explain its ability to promote protective Treg activity in cellular and rodent models of inflammatory disease. AhR agonists also promote transcription of the gene coding for Nrf-2, and hence can up-regulate phase 2 induction of antioxidant enzymes such as HO-1. Hence, it is proposed that C-Phycocyanin/PCB chiefly exert their protective effects via inhibition of NADPH oxidase activity, as well as by AhR agonism that both induces Treg activity and up-regulates phase 2 induction. This simple model may explain their potent antioxidant/anti-inflammatory effects. Additionally, PCB might mimic biliverdin in activating anti-inflammatory signaling mediated by biliverdin reductase. This essay reviews recent research in which C-Phycocyanin and/or PCB, administered orally, parenterally, or intranasally, have achieved marked protective effects in rodent and cell culture models of Ischemic Stroke and Multiple Sclerosis, and suggests that these agents may likewise be protective for Alzheimer’s disease, Parkinson’s disease, and in COVID-19 and its neurological complications.

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“…Phycocyanin (PC) is a bright blue-colored, water-soluble, pigment-protein complex that is used as a natural pigment and fluorescent marker owing to its unique physical and chemical properties. In recent years, studies have shown that PC also has a variety of biological functions, including antioxidant [ 1 , 2 ], anti-inflammatory [ 3 ], antitumor [ 4 ], and liver protective activities [ 5 ]. These findings indicate that PC may have great potential applications in functional food, biological detection, and medicine fields.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Mg-Doped Calcium Phosphate-Coated Phycocyanin Nanoparticles for Improving the Thermal Stability of Phycocyanin

Dong

2022

Foods

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Phycocyanin (PC) is a blue-colored, pigment-protein complex with unique fluorescence characteristics. However, heat leads to PC fading and fluorescence decay, hampering its widespread application. To improve the thermal stability of PC, we induced the in situ mineralization of calcium phosphate (CaP) on the PC surface to prepare PC@Mg-CaP. The nanoparticles were characterized using transmission electron microscopy, energy dispersive spectrometry, fourier transform infrared spectroscopy, and X-ray diffraction. The results showed that PC@Mg-CaP was spherical, and the nanoparticle size was less than 200 nm. The shell of PC@Mg-CaP was composed of amorphous calcium phosphate (ACP). The study suggested that CaP mineralization significantly improved the thermal stability of PC. After heating at 70 °C for 30 min, the relative concentration of PC@Mg-CaP with a Ca/P ratio = 2 was 5.31 times higher than that of PC. Furthermore, the Ca/P ratio was a critical factor for the thermal stability of PC@Mg-CaP. With decreasing Ca/P, the particle size and thermal stability of PC@Mg-CaP significantly increased. This work could provide a feasible approach for the application of PC and other thermal-sensitive biomolecules in functional foods requiring heat treatment.

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Potential use of C-phycocyanin in non-alcoholic fatty liver disease

Cited by 18 publications

References 32 publications

Phycobiliproteins: Structural aspects, functional characteristics, and biotechnological perspectives

Phycobiliproteins: Structural aspects, functional characteristics, and biotechnological perspectives

C-Phycocyanin-derived Phycocyanobilin as a Potential Nutraceutical Approach for Major Neurodegenerative Disorders and COVID-19- induced Damage to the Nervous System

Preparation and Characterization of Mg-Doped Calcium Phosphate-Coated Phycocyanin Nanoparticles for Improving the Thermal Stability of Phycocyanin

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