Potential urine biomarkers for gestational hypertension and preeclampsia

Guo, Haipeng; Zhu, Yanbin; Wu, Changcai; Zhong, Ming; Hu, Shuiwang

doi:10.3892/mmr.2019.9911

Cited by 14 publications

(11 citation statements)

References 22 publications

(24 reference statements)

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“…Plasma ET-1 is associated with hemodynamic changes during normal pregnancy. ET-1 showed no significant difference in the first and second trimester, but increased significantly in the third trimester, interacting with other vasoactive substances to regulate blood pressure and hemodynamic changes [ 34 – 37 ]. In this study, the levels of NO and SOD increased in both groups after treatment, and the experimental group was significantly higher than the control group.…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Pinggan Yiqi Yangshen Recipe Combined with Labetalol Hydrochloride and Magnesium Sulfate in the Treatment of PIH

Zhao²,

Gao³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. To observe the clinical effect of Pinggan Yiqi Yangshen recipe combined with labetalol hydrochloride and magnesium sulfate in the treatment of pregnancy-induced hypertension (PIH). Methods. A total of 126 patients with PIH diagnosed in our hospital from January 2016 to May 2018 were randomly divided into the control group and the experimental group, with 63 cases in each group. The control group was treated with labetalol combined with magnesium sulfate. On the basis of the control group, the experimental group was treated with Pinggan Yiqi Yangshen recipe. Clinical efficacy, blood pressure, renal function, and biochemical indexes were compared between the two groups. Moreover, pregnancy outcomes and adverse reactions were compared between the two groups. Results. After treatment, the total effective rate in the experimental group was higher than in the control group. Blood pressure and mean arterial pressure in the experimental group were more significantly downregulated than the control group. Renal function indexes and biochemical indexes in the experimental group were more significant than those in the control group. The incidence of cesarean section, preterm birth, and abnormal fetal heart rate in the experimental group was significantly lower than that in the control group. There was no difference in the incidence of fetal distress, postpartum hemorrhage, neonatal asphyxia, and adverse reactions between the two groups. Conclusion. Pinggan Yiqi Yangshen recipe combined with labetalol hydrochloride and magnesium sulfate can effectively reduce the blood pressure of patients with PIH, help patients to return to normal levels of biochemical indexes and renal function indexes, and improve pregnancy outcomes with high safety, which is worthy of further promotion and application in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Pinggan Yiqi Yangshen Recipe Combined with Labetalol Hydrochloride and Magnesium Sulfate in the Treatment of PIH

Zhao²,

Gao³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Likewise, early preeclampsia with or without HELLP (hemolysis, elevated liver enzymes, and a low platelet count) syndrome was associated with an increased placental perlecan expression that showed a positive correlation with maternal vascular malperfusion [176]. In contrast, the findings by Guo et al showed decreased perlecan concentration in urine when compared the gestational hypertension group with controls, indicating glomerular filtration barrier injury and renal dysfunction [177]. Collectively, these observations paint a complex and underexplored role for perlecan in hypertension in the cerebrovasculature and beyond.…”

Section: Perlecan and The Cerebrovasculature In Disease And Strokementioning

confidence: 95%

Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia

Trout

Rutkai

Biose

et al. 2020

IJMS

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Perlecan is a heparan sulfate proteoglycan protein in the extracellular matrix that structurally and biochemically supports the cerebrovasculature by dynamically responding to changes in cerebral blood flow. These changes in perlecan expression seem to be contradictory, ranging from neuroprotective and angiogenic to thrombotic and linked to lipid retention. This review investigates perlecan’s influence on risk factors such as diabetes, hypertension, and amyloid that effect Vascular contributions to Cognitive Impairment and Dementia (VCID). VCID, a comorbidity with diverse etiology in sporadic Alzheimer’s disease (AD), is thought to be a major factor that drives the overall clinical burden of dementia. Accordingly, changes in perlecan expression and distribution in response to VCID appears to be injury, risk factor, location, sex, age, and perlecan domain dependent. While great effort has been made to understand the role of perlecan in VCID, additional studies are needed to increase our understanding of perlecan’s role in health and in cerebrovascular disease.

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“…As such, the urinary content of around 50 different specific proteins is different in preeclampsia than in normal pregnancy – a focus of current research using urinary proteomics (Guo et al . ) to discriminate between types of gestational hypertensive disorders.…”

Section: Cardiovascular and Renal Characteristics Of Preeclampsiamentioning

confidence: 99%

Preeclampsia: a gestational cardiorenal syndrome

Gyselaers

Thilaganathan

2019

The Journal of Physiology

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It is generally accepted today that there are two different types of preeclampsia: an early‐onset or placental type and a late‐onset or maternal type. In the latent phase, the first one presents with a low output/high resistance circulation eventually leading in the late second or early third trimester to an intense and acutely aggravating systemic disorder with an important impact on maternal and neonatal mortality and morbidity; the other type presents initially as a high volume/low resistance circulation, gradually evolving to a state of circulatory decompensation usually in the later stages of pregnancy, with a less severe impact on maternal and neonatal outcome. For both processes, numerous dysfunctions of the heart, kidneys, arteries, veins and interconnecting systems are reported, most of them presenting earlier and more severely in early‐ than in late‐onset preeclampsia; however, some very specific dysfunctions exist for either type. Experimental, clinical and epidemiological observations before, during and after pregnancy are consistent with gestation‐induced worsening of subclinical pre‐existing chronic cardiovascular dysfunction in early‐onset preeclampsia, and thus sharing the pathophysiology of cardiorenal syndrome type II, and with acute volume overload decompensation of the maternal circulation in late‐onset preeclampsia, thus sharing the pathophysiology of cardiorenal syndrome type 1. Cardiorenal syndrome type V is consistent with the process of preeclampsia superimposed upon clinical cardiovascular and/or renal disease, alone or as part of a systemic disorder. This review focuses on the specific differences in haemodynamic dysfunctions between the two types of preeclampsia, with special emphasis on the interorgan interactions between heart and kidneys, introducing the theoretical concept that the pathophysiological processes of preeclampsia can be regarded as the gestational manifestations of cardiorenal syndromes.

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Potential urine biomarkers for gestational hypertension and preeclampsia

Cited by 14 publications

References 22 publications

Clinical Evaluation of Pinggan Yiqi Yangshen Recipe Combined with Labetalol Hydrochloride and Magnesium Sulfate in the Treatment of PIH

Clinical Evaluation of Pinggan Yiqi Yangshen Recipe Combined with Labetalol Hydrochloride and Magnesium Sulfate in the Treatment of PIH

Review of Alterations in Perlecan-Associated Vascular Risk Factors in Dementia

Preeclampsia: a gestational cardiorenal syndrome

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