Potential Unmet Needs in Acute Treatment of Migraine in Japan: Results of the OVERCOME (Japan) Study

Takeshima, Takao; Ueda, Kaname; Komori, Mika; Zagar, Anthony; Kim, Yongin; Jaffe, Dena H.; Matsumori, Yasuhiko; Hirata, Koichi

doi:10.1007/s12325-022-02289-w

Cited by 14 publications

(17 citation statements)

References 27 publications

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“…More male respondents were in full-time employment than female respondents (80.3% and 43.8%, respectively). As reported previously [ 5 , 13 ], there was evidence of substantial disability, with 20.7% of respondents being in the moderate-to-severe MIDAS categories and 37.4% reporting severe impairment or requiring bed rest. There was also evidence of substantial interictal burden, with 41.5% of respondents in the moderate-to-severe MIBS-4 categories.…”

Section: Resultssupporting

confidence: 77%

“… Data are n (%) unless otherwise specified a Previously reported [ 5 , 12 ] b Other categories for marital status: single, divorced, separated, widowed, and prefer not to say; married respondents previously reported [ 5 , 12 ] c Survey respondents were included in the migraine cohort if they met the modified ICHD-3 criteria for migraine or reported that a physician had diagnosed them with migraine. The number reported here includes all respondents who reported a diagnosis of migraine (most of whom also met ICHD-3 criteria) d Previously reported [ 12 ] e Previously reported (percentages only) [ 13 ] f Previously reported (percentages only) [ 5 ] g The WPAI-M total daily activity impairment score is the mean percentage of time that daily activities were impaired due to migraine in the previous 7 days ICHD-3 International Classification of Headache Disorders, third edition, MIBS Migraine Interictal Burden Scale, MIDAS Migraine Disability Assessment, SD standard deviation, WPAI-M Work Productivity and Activity Impairment-Migraine …”

Section: Resultsmentioning

confidence: 99%

“…The ObserVational survey of the Epidemiology, tReatment, and Care Of MigrainE (OVERCOME [Japan]) study is a cross-sectional survey that provides an observational “snapshot” of people with migraine in Japan. Previous analyses of OVERCOME (Japan) data have described symptomatology, diagnosis, and treatment [ 12 ]; disability, quality of life, and work impairment [ 5 ]; potential unmet treatment needs [ 13 ]; and factors associated with insufficient effectiveness of acute treatment [ 14 ]. However, the impacts of migraine on daily, non-work activities and fundamental health indicators have not previously been described in detail for people with migraine in Japan.…”

Section: Introductionmentioning

confidence: 99%

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Impact of Migraine on Daily Life: Results of the Observational survey of the Epidemiology, Treatment, and Care of Migraine (OVERCOME [Japan]) Study

Awaki,

Takeshima,

Matsumori

et al. 2024

Neurol Ther

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Introduction The impacts of migraine on daily life, including daily activities and fundamental health indicators (sleep and mental health), have not been described in detail for people with migraine in Japan. Methods The cross-sectional ObserVational survey of the Epidemiology, tReatment, and Care Of MigrainE (OVERCOME [Japan]) study was conducted between July and September 2020. Impacts of migraine on housework, family/social/leisure activities, driving, and sleep were assessed using questions from the Migraine Disability Assessment (MIDAS), Migraine-Specific Quality-of-Life Questionnaire, and Impact of Migraine on Partners and Adolescent Children scales and questions developed for OVERCOME (Japan). The Migraine Interictal Burden Scale (MIBS-4) evaluated burden on days without headaches. Depression and anxiety were assessed with the Patient Health Questionnaire (PHQ-8) and Generalized Anxiety Disorder (GAD-7) scales, respectively. Impacts on daily life were also described across MIDAS/MIBS-4 categories. Results Among 17,071 respondents with migraine, 24.8% required assistance with housework at least sometimes. Migraine interfered with relationships, leisure, and social activities at least sometimes for 31.8%, 41.6%, and 18.0% of respondents, respectively. Between headache days, 26.8% of respondents worried about planning social/leisure activities at least sometimes. Among respondents living with family ( N = 13,548), migraine also had impacts on participation in and enjoyment of family activities. Among respondents who drove ( N = 10,921), 43.9% reported that symptoms interfered with driving at least sometimes. Migraine interfered with sleep and mood at least sometimes for 52.7% and 70.7% of respondents, respectively. PHQ-8 and GAD-7 thresholds for clinical depression and anxiety were met by 28.6% and 22.0% of respondents, respectively. Impact of migraine on daily life increased with increasing severity of MIDAS/MIBS-4 categories. Conclusion The burden of migraine on daily activities, sleep, and mental health is substantial for people with migraine in Japan. In clinical practice, it is important to evaluate the impact of migraine on daily life in addition to migraine symptoms. Supplementary Information The online version contains supplementary material available at 10.1007/s40120-023-00569-3.

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Section: Resultssupporting

confidence: 77%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Migraine on Daily Life: Results of the Observational survey of the Epidemiology, Treatment, and Care of Migraine (OVERCOME [Japan]) Study

Awaki,

Takeshima,

Matsumori

et al. 2024

Neurol Ther

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“…Recently, Japanese researchers have shown growing awareness of the effects of headache disorders on the overall health of the Japanese population [7][8][9][10][11][12][13][14]. These studies have revealed several consequences for people with migraines, including an unmet need for migraine healthcare, increased burden and disability, decreased quality of life, productivity impairment, and employer costs.…”

Section: Introductionmentioning

confidence: 99%

Different effects of migraine associated features on disability and psychiatric conditions in patients with migraine without aura: a multicenter observational cohort study

Imai,

Matsumori

2024

Preprint

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Background: Migraine is a multifactorial brain disorder characterized by recurrent disabling headaches and their associated features. Several studies have suggested that these features are related to migraine disabilities and psychiatric conditions. However, differences in the impact of each associated feature on migraine disability or psychiatric conditions remain unclear. This study aimed to assess the impact of migraine-associated features on disability and psychiatric conditions in patients with migraine. Methods: We enrolled patients with migraine without aura (MwoA) to exclude those with migraine without headache and to avoid the influence of medication overuse headache, which is commonly associated with chronic migraine. We assessed the impact of associated features on disability or psychiatric conditions using multivariate logistic regression analyses. Associated symptoms included nausea, vomiting, photophobia, phonophobia, osmophobia, and allodynia. Migraine disability and psychiatric conditions were determined using the Headache Impact Test (HIT-6), Visual Analog Scale (VAS), Generalized Anxiety Disorder 7-item scale (GAD-7), and the Patient Health Questionnaire-9 (PHQ-9). Results: In total, 1103 patients with MwoA were enrolled in this study. One hundred twenty-five patients were excluded from the study because of missing data. Finally, 939 patients with MwoAs were included in this study. On multivariate logistic regression analyses, nausea (odd ratios [OR] 1.87, confidence interval [CI]: 1.37-2.54), vomiting (OR 1.57, CI: 1.11-2.23), photophobia (OR 1.67, CI: 1.18-2.35), and allodynia (OR 1.56, CI: 1.06-2.28) were independent positive predictors of higher HIT-6 scores, and nausea (OR 1.72, CI: 1.22-2.43), vomiting (OR 1.84, CI: 1.29-2.63), phonophobia (OR 1.58, CI: 1.10-2.25), photophobia (OR 1.49, CI: 1.07-2.08), and allodynia (OR 1.81, CI: 1.24-2.66) were independent positive predictors of higher VAS score. Nausea (OR 1.49, CI: 1.09-2.02), phonophobia (OR 2.00, CI: 1.42-2.82), and allodynia (OR 1.81, CI: 1.24-2.63) were independent positive predictors of GAD-7 score. Nausea (OR 1.66, CI: 1.21-2.28), phonophobia (OR 1.49, CI: 1.05-2.11), and allodynia (OR 1.68, CI: 1.16-2.45) were independent positive predictors and vomiting (OR 0.54, CI: 0.37-0.78) was an independent negative predictor of PHQ-9 score. Conclusions: Our results suggest that nausea, vomiting, photophobia, phonophobia, and osmophobia have distinct effects on migraine disability and psychiatric conditions. Understanding these differences can aid in personalized management of patients with MwoA.

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“…Despite their global impact, there is a notable gap in comprehensive research focused on the clinical characteristics of patients in these settings, particularly in Japan where the prevalence of headaches is comparable to, if not slightly lower than, that observed in Western countries [2][3][4]. Recent efforts by Japanese researchers have highlighted the societal burden of headache disorders [5][6][7][8][9][10][11][12][13][14], yet studies that systematically investigate the clinical pro les of patients attending specialized headache clinics remain remarkably scarce. This gap limits our capacity to tailor patient care effectively and to devise interventions that meet the unique needs of this patient group.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of 2,378 patients presenting with headache disorders to headache clinics in Japan: A clinic-based multicenter study

Imai,

Takizawa,

Watanabe

et al. 2024

Preprint

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Background There are single-center reports regarding patients visiting headache clinics; however, few multicenter studies have been conducted in Japan. This study aims to fill the aforementioned gaps by providing a detailed analysis of the clinical characteristics, headache types, severity, and psychiatric comorbidities of patients presenting to headache clinics across three distinct healthcare settings in Japan: a university hospital, regional headache center, and private headache clinic. Methods We prospectively evaluated the clinical characteristics of 2,378 patients with headache disorders visiting three Japanese Headache Society–accredited headache educational facilities between March 2021 and March 2022. Baseline demographics, such as the visual analog scale (VAS), and psychiatric assessments, such as the Japanese versions of the Generalized Anxiety Disorder-7 (GAD-7) and the Patient Health Questionnaire-9 (PHQ-9), were evaluated. Headache types were classified as migraine, tension-type headache (TTH), trigeminal autonomic cephalalgias (TACs), other primary headache disorders (OPHDs), and secondary headache. Parameters were compared between headache types using the Kruskal–Wallis test. Results The most common headache type was migraine (78.8%), followed by TTH (12.2%), secondary headache (5.5%), OPHDs (2.1%), and TACs (1.6%). Patients with migraine were significantly younger at first consultation (median age 32.0) than those with other headache types (TTH; 47.0, TACs; 39.0, OPHDs; 49.5, and secondary headache; 47.0). Patients with TACs exhibited the highest severity and psychiatric symptoms, with VAS (median 90.0), GAD-7 (7.0), and PHQ-9 (7.5) scores significantly higher than those of other headache type (migraine; 70.0, 5.0, 5.0, TTH; 50.0, 4.0, 4.0, OPHDs; 65.0, 4.0, 3.5, and secondary headache; 60.0, 3.0, 3.5: p < 0.001, p = 0.032, p < 0.001). Conclusion Most patients visiting headache clinics had migraine; patients with TACs showed significantly higher headache severity and psychiatric symptoms than those with other headache types.

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Potential Unmet Needs in Acute Treatment of Migraine in Japan: Results of the OVERCOME (Japan) Study

Cited by 14 publications

References 27 publications

Impact of Migraine on Daily Life: Results of the Observational survey of the Epidemiology, Treatment, and Care of Migraine (OVERCOME [Japan]) Study

Impact of Migraine on Daily Life: Results of the Observational survey of the Epidemiology, Treatment, and Care of Migraine (OVERCOME [Japan]) Study

Different effects of migraine associated features on disability and psychiatric conditions in patients with migraine without aura: a multicenter observational cohort study

Clinical characteristics of 2,378 patients presenting with headache disorders to headache clinics in Japan: A clinic-based multicenter study

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