Potential Trends of Point-of-Care Diagnostics—The Next Generation of the Laboratory Diagnosis

Sheng, Lin; Shen, Ching Fen; Cheng, Chao

doi:10.3390/diagnostics10100774

Cited by 1 publication

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“…Esta prueba supone un avance aplicable en algunos pacientes sintomáticos pero se requiere seguir avanzando para poner a punto una herramienta diagnóstica rápida más efectiva que permita controlar la propagación de la enfermedad especialmente en pacientes asintomáticos con baja carga viral [27,28].…”

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Evaluation of the validity of Ag PANBIO-COVID19 in the diagnosis of SARS-CoV-2 infection in asymptomatic or mildly infected patients

Gras-Valentí¹,

Vidal²,

Montiel-Higuero³

et al. 2021

Rev Esp Quimioter

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Objective. To assess the validity of SARS-CoV-2 Antigen (Ag) detection for the diagnosis of SARS-CoV-2 infection in mildly infected or asymptomatic patients. Material and methods. Observational study to evaluate diagnostic tests. Non-hospitalized patients with indication for diagnostic testing for SARS-CoV-2 infection were included. The diagnostic test to be evaluated was the determination of Ag and as a reference standard to determine the presence of viral RNA the RT-PCR was used. Results. A total of 494 patients were included. Of these 71.5% (353/494) had symptoms and 28.5% (141/494) were asymptomatic (presurgery screening (35/494) and confirmed case-contact (106/494). The overall sensitivity of the Ag test was 61.1% and the specificity was 99.7%. The sensitivity and specificity in the asymptomatic group were 40% and 100% respectively, and in the symptomatic group 63.5% and 99.6% respectively. In turn, the sensitivity and specificity in the group of symptomatic patients varied according to the time of symptom evolution: in patients with recent symptoms, they were 71.4% and 99.6% respectively, while in patients with symptoms of more than 5 days of evolution, they were 26.7% and 100% respectively. In all groups studied, the presence of antigen is associated with a high viral load (Ct<30 cycles). Conclusions. The use of Ag detection test is not indicated for the diagnosis of SARS-CoV-2 infection in asymptomatic patients or with symptoms of more than 5 days of evolution, but it could be useful in patients with symptoms of 1-5 days of evolution.

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Section: Discussionunclassified

Evaluation of the validity of Ag PANBIO-COVID19 in the diagnosis of SARS-CoV-2 infection in asymptomatic or mildly infected patients

Gras-Valentí¹,

Vidal²,

Montiel-Higuero³

et al. 2021

Rev Esp Quimioter

View full text Add to dashboard Cite

show abstract

Potential Trends of Point-of-Care Diagnostics—The Next Generation of the Laboratory Diagnosis

Abstract: With the current worldwide outbreak of COVID-19, developing rapid, effective, and convenient detection tools has become imperative [...]

Cited by 1 publication

References 6 publications

Evaluation of the validity of Ag PANBIO-COVID19 in the diagnosis of SARS-CoV-2 infection in asymptomatic or mildly infected patients

Evaluation of the validity of Ag PANBIO-COVID19 in the diagnosis of SARS-CoV-2 infection in asymptomatic or mildly infected patients

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