POTENTIAL TRACKING OF CYTOTOXIC ACTIVITIES OF MANGROVE PEREPATE (Sonneratia alba) ROOT EXTRACT AS AN ANTICANCER CANDIDATE

Latief, Madyawati; Nelson, Nelson; Amanda, Hilda; Tarigan, Indra Lasmana; Aisyah, Siti

doi:10.15416/pcpr.v5i2.26790

Cited by 12 publications

(17 citation statements)

References 8 publications

(14 reference statements)

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“…Sampel yang digunakan pada penelitian ini adalah daun sungkai yang telah dipreparasi terlebih dahulu (Latief et al, 2020). Setelah itu dilakukan perajangan untuk memperluas permukaan sampel agar sampel dapat kering dengan merata dengan lebar daun ±2 cm.…”

Section: Simplisia Daun P Canescens Jackunclassified

Aktivitas Antihiperurisemia Ekstrak Etanol Daun Sungkai (Peronema canescens Jack) Pada Mencit Putih Jantan

et al. 2021

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Hyperuricemia is a disease caused by an increase in uric acid levels in the blood. Currently, various treatments are developed by utilizing natural ingredients as an anti-hyperuricemia. Sungkai (Peronema canescens Jack) is one of the plants that contain a natural compound that can use as an anti-hyperuricemia treatment is the leaves of sungkai (Peronema canescens Jack.). The aim of this study to determine the anti-hyperuricemia activity of the ethanol extract of Sungkai leaves. The test animals used in this study were male white mice Wistar strain. This study used a completely randomized design (CRD) with 5 groups consisting of negative control (Na CMC 0.5%) positive control (allopurinol 10 mg / kg BW), treatment 1 (extract 125 mg / kg BW), treatment 2 (extract 250 mg / kg BW) and treatment 3 (extract 500 mg / kg BW). The parameters seen were uric acid levels measured using the POCT (Point of Care Test) method and analyzed using One Way Anova statistical analysis and Duncan's continued test. Our results showed that the treatment group with a dose of 125-500 mg / Kg BW reduce uric acid levels in mice. The best dose was a dose of 500 mg / Kg BW in reducing uric acid levels in mice with percent decline of 38.66%.

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Section: Simplisia Daun P Canescens Jackunclassified

Aktivitas Antihiperurisemia Ekstrak Etanol Daun Sungkai (Peronema canescens Jack) Pada Mencit Putih Jantan

et al. 2021

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“…Penelitian mengenai eksplorasi senyawa antibakteri baru yang berasal dari bahan alami terus mengalami perkembangan. Salah satu tumbuhan yang menjadi alternatif sumber senyawa antibakteri tersebut adalah tumbuhan mangrove, Sonneratia alba (Latief et al, 2019;Latief et al, 2020).…”

Section: Pendahuluanunclassified

“…Penelitian tentang kandungan metabolit sekunder yang telah dilakukan sebelumnya pada ekstrak metanol daun S. alba menunjukkan bahwa terdapat berbagai senyawa metabolit sekunder, salah satunya adalah alkaloid (Latief et al, 2019;Latief et al, 2020). Secara farmakologis, alkaloid diketahui memiliki banyak aktivitas biologis seperti antibakteri, antiradang, serta antioksidan.…”

Section: Pendahuluanunclassified

“…Uji aktivitas antimikroba pada ekstrak n-heksan, etil asetat, dan metanol daun dan buah S. alba menunjukkan hasil positif untuk S. aureus, bakteri E. coli, dan jamur C. albicans. Selain itu, ekstrak etil asetat dan metanol dari daun S. alba juga terbukti memiliki aktivitas antimikroba pada bakteri gram positif S. aureus dan B. cereus dan E. coli gram negatif serta pada jamur C. neoformans (Latief et al, 2019;Latief et al, 2020;Latief et al, 2018;Muhaimin et al, 2019;Saad et al, 2012).…”

Section: Pendahuluanunclassified

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Isolation of alkaloids compound of ethanol extract of mangrove perepat (S. alba) root and its antibacterial activity

Latief

Muhaimin

Amanda

et al. 2021

JIF

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Background: Exploration of the chemical contents and bioactivities of mangrove plants is important to discover new therapeutic agents for society and to develop its medicinal values. Objective: This study aims to isolate alkaloid compounds from the ethanol extract of Sonneratia alba root which is likely to have an antibacterial activity. Methods: Isolation was carried out using fractionation and chromatography, while antibacterial activity test was performed using the disc diffusion methods. Results: Our phytochemical screening shows that the ethanol extract has a high concentration of alkaloid compounds. The alkaloid which contain in isolate (F4) is further confirmed through UV-Vis Spectra and FT-IR spectra. The ethanol extract exhibits the antibacterial activity against S. aureus and E. coli with the inhibition zone of 1.5 mm and 2.5 mm, respectively. Conclusion: Alkaloid compound has been isolated from Sonneratia alba and has potential as antibacterial agent. Keywords: mangrove perepat (Sonneratia alba), alkaloid, antibacterial agent

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“…Purification of the main components contained in the active fraction was carried out by column chromatography and recrystallization until a pure compound with a single stain was obtained at TLC. 10,11…”

Section: Extraction Isolation and Fractionationmentioning

confidence: 99%

Anti-inflammatory activities of squalene compound of methanol extract of Abroma augusta L

Latief¹,

Muhaimin²,

Amanda³

et al. 2020

J. Teknol. Laboratorium

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Abroma augusta L plant traditionally was used to treat swellings, cuts, sores, and bruises. In the province of Jambi, A. augusta is used in folk medicine to treat wounds. This study aims to isolate the steroid compound from the root of A. augusta L and determine its anti-inflammatory activities. Extraction and fractionation have been done with graded maceration using solvents with different polarities, which are n-hexane, ethyl acetate, and methanol. The separation was performed by column chromatography, followed by preparative thin-layer chromatography. The characterization of the isolate was carried out using UV-Vis spectrophotometry and infrared spectrophotometry, GC-MS. The anti-inflammatory activities of methanol extract and isolate of A. augusta was performed in this study was designed to evaluate the dose-response relationship of the anti-inflammatory activity in rat models of chronic inflammation chromatography to obtain isolate 2.1.1 that characterize and showed maximum absorbance at 265. The result of IR showed the presence of functional groups, -C=C-H, -C=H, -CH, CH3, CH2, and –CO belongs to the steroid compound. The results of the GC-MS show that isolates contain squalene compounds with a value of m/z 410, Isolate and crude extract showed an anti-inflammatory activity that almost approached the positive control of sodium 4-chlorophenolate. It could be concluded that isolate and extract provide good anti-inflammatory activity, that promise for new drug candidate squalene-based A. augusta.

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POTENTIAL TRACKING OF CYTOTOXIC ACTIVITIES OF MANGROVE PEREPATE (Sonneratia alba) ROOT EXTRACT AS AN ANTICANCER CANDIDATE

Cited by 12 publications

References 8 publications

Aktivitas Antihiperurisemia Ekstrak Etanol Daun Sungkai (Peronema canescens Jack) Pada Mencit Putih Jantan

Aktivitas Antihiperurisemia Ekstrak Etanol Daun Sungkai (Peronema canescens Jack) Pada Mencit Putih Jantan

Isolation of alkaloids compound of ethanol extract of mangrove perepat (S. alba) root and its antibacterial activity

Anti-inflammatory activities of squalene compound of methanol extract of Abroma augusta L

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