Potential therapeutic targets for sarcopenia identified by Mendelian randomisation

Jiang, Wei; Zhan, Wenli; Zhou, Luo-Qi; Dong, Minghao; Liu, Liang; Xu, Xiangjie; Cao, Zhixin

doi:10.1093/ageing/afad024

Cited by 7 publications

(5 citation statements)

References 62 publications

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“…The percentage of elderly people with frailty (25.9%) is lower than the percentage of elderly people without frailty (74.1%), and the risk of depressive symptoms in frailty is significantly higher than that in non-fragility. This result is supported by a previous study conducted by Sang et al [24] Sang et al used a two-way 2 sample Mendelian randomization study to study the causal relationship between depression and frailty. The results showed that univariate analysis showed that depression was positively correlated with the risk of frailty.…”

Section: Discussionsupporting

confidence: 78%

The relationship between frailty, walking ability, and depression in elderly Chinese people

Yin,

Gao,

Quan

et al. 2023

Medicine

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To explore the relationship between depression symptoms, frailty, and walking ability in Chinese elderly people, and to provide new evidence for research on the prevention and treatment of depression in Chinese elderly people. The data of this study is sourced from the 2018 CHARLS data (China Health and Retirement Longitudinal Study). Z-test, logistic regression, and linear stratified regression were used to analyze the walking ability, frailty, and depressive symptoms of 2927 participants. Good walking ability and non frailty were significantly negatively correlated with depression symptoms in the elderly (P < .05). This important negative association persists even after adjusting for demographic, health condition, and lifestyle factors. (P < .05). Elderly women are at a higher risk of developing depression than men, while elderly people with good walking ability and no frailty are at a lower risk of developing depression. At the same time, elderly people with disabilities, hypertension, arthritis, and low levels of physical activity are more likely to experience depressive symptoms. It is recommended that elderly people pay attention to maintaining walking ability and avoiding frailty to reduce the risk of depression.

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Section: Discussionsupporting

confidence: 78%

The relationship between frailty, walking ability, and depression in elderly Chinese people

Yin,

Gao,

Quan

et al. 2023

Medicine

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“…In addition, sex chromosome genes in females with cancer are more prone to losing their stability compared to males. This increases the likelihood of a mitochondrial metabolic imbalance and impaired muscle oxidation capacity in females, ultimately making them more susceptible to muscle atrophy [ 43 , 44 ]. This study further analyzed several types of cancer with relatively larger sample sizes among the 1,602 individuals with cancer and sarcopenia, and discovered an important connection between sarcopenia and the NHHR in individuals with breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and sarcopenia in individuals with cancer: a cross-sectional study

He,

Ye,

Zhu

et al. 2024

Lipids Health Dis

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Background Cancer and sarcopenia are both closely related to lipid metabolism, but the relationship between lipid metabolism and patients with cancer and sarcopenia has not been thoroughly studied. The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) is a reliable measure of lipid metabolism. The purpose of this study was to determine the possible relationship between the NHHR and sarcopenia in individuals with cancer. Methods Data from the National Health and Nutrition Examination Survey (NHANES) database for individuals with cancer, with and without sarcopenia was analyzed using weighted multiple regression equations, weighted regression cubic spline (RCS) analysis, and weighted subgroup analysis. Results In total, 1,602 individuals with cancer were included, of whom 17.1% had sarcopenia. In Adjusted Model 2, the occurrence of sarcopenia was found to be significantly associated with a higher NHHR in cancer (95% confidence interval [CI]:1.01–1.39, P = 0.036). Individuals with high a NHHR had a 2.09-fold higher risk of developing sarcopenia in comparison to those with a low NHHR (95% CI:1.12–3.92, P = 0.022). RCS analysis further identified a U-shaped non-linear relationship between females with cancer and the muscle index. Subgroup analysis indicated that sex was a significant stratifying factor, whereas age, race, marital status, smoking and drinking habits, and history of cardiovascular disease, arthritis, hypertension, and diabetes had no significant impact. Conclusion From the perspective of lipid metabolism, the NHHR may serve as an indicator for monitoring and preventing the occurrence of sarcopenia in individuals with cancer, particularly for females with cancer who appear to have greater sensitivity.

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“…Internationally, there are different diagnostic criteria for sarcopenia. DXA measures the appendicular skeletal muscle mass index (ASMI), which represents muscle mass, while grip strength serves as the muscle strength index, and daily gait speed indicates the physical fitness index 7 . Sarcopenia can be diagnosed when the corresponding measurements are lower than the above values.…”

Section: Introductionmentioning

confidence: 99%

The original scores of traditional Chinese medicine constitutions are risk and diagnostic factors in middle‐aged and older adults with sarcopenia

Nie,

Wang,

Zhang

et al. 2024

Aging Medicine

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ObjectiveSarcopenia is a geriatric syndrome that occurs with age and is characterized by a gradual decline in muscle mass, power, and functionality. It serves as a prominent contributor to frailty, disability, and mortality among older individuals. Currently, no standardized global guidelines exist for the diagnosis of sarcopenia. This study aimed to establish the correlation between sarcopenia and the constitutions of traditional Chinese medicine (TCM), considering the connection between physical functioning and sarcopenia.MethodsA total of 1441 participants in this study were diagnosed with sarcopenia. The Asian Working Group for Sarcopenia (AWGS) proposed a sarcopenia definition algorithm. To determine the constitution of each participant, classification and determination standards were used in traditional Chinese medicine. This study evaluated the demographics, lifestyles, and self‐reported medical history of individuals diagnosed with sarcopenia through a self‐administered questionnaire. The constitution of the participants was determined using TCM classification and determination standards. Subsequently, we analyzed the results of univariate analysis and multivariate regression and constructed a receiver operating characteristic (ROC) curve.ResultsParticipants who were diagnosed with sarcopenia had substantially lower original Neutral constitution scores (P < 0.050). In comparison to those without sarcopenia, individuals with sarcopenia exhibited notably elevated original Qi‐deficiency, Yang‐deficiency, Yin‐deficiency, Blood‐stagnation, and Qi‐stagnation scores in contrast to those in the healthy group (P < 0.050). The identified risk factors associated with sarcopenia included the following: Neutral (OR = 0.903), Qi‐deficiency (in males, OR = 1.126), Yang‐deficiency (OR = 1.062), Phlegm‐dampness (in males, OR = 0.833), and Blood‐stagnation (in females, OR = 1.089). The highest area under the curve (AUC) was observed for the original neutral constitution score, followed by the Yang‐deficiency and blood‐stagnation scores (0.644, 0.613, and 0.611, respectively). Additionally, the AUC for the combined original scores of all nine constitutions among males reached 0.778.ConclusionsIn this cross‐sectional study of older people with higher original Qi‐deficiency, Yin deficiency, Yang‐deficiency, Blood‐stagnation, and Qi‐stagnation were associated with sarcopenia. Notably, various TCM constitutions are significantly linked to sarcopenia. There was a significant occurrence of various body constitution types among individuals diagnosed with sarcopenia. The mixture of the nine original constitution scores exhibited good diagnostic performance for sarcopenia in males.

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Potential therapeutic targets for sarcopenia identified by Mendelian randomisation

Cited by 7 publications

References 62 publications

The relationship between frailty, walking ability, and depression in elderly Chinese people

The relationship between frailty, walking ability, and depression in elderly Chinese people

Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and sarcopenia in individuals with cancer: a cross-sectional study

The original scores of traditional Chinese medicine constitutions are risk and diagnostic factors in middle‐aged and older adults with sarcopenia

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