Potential therapeutic role of spermine via Rac1 in osteoporosis: Insights from zebrafish and mice
Rui-Xue Jiang,
Nan Hu,
Yu-Wei Deng
et al.
Abstract:Osteoporosis (OP) is a prevalent metabolic bone disease. While drug therapy is essential to prevent bone loss in osteoporotic patients, current treatments are limited by side effects and high costs, necessitating the development of more effective and safer targeted therapies. Utilizing a zebrafish (
Danio rerio
) larval model of osteoporosis, we explored the influence of the metabolite spermine on bone homeostasis. Results showed that spermine exhibited dual activity in osteoporotic zebr… Show more
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