Potential therapeutic effect and methods of traditional Chinese medicine on <scp>COVID‐19</scp>‐induced depression: A review

Da, Xiaoli; Yue, Lifeng; Li, Xiaojuan; Chen, Jianbei; Yuan, Naijun; Chen, Jiaxu

doi:10.1002/ar.24758

Cited by 10 publications

(10 citation statements)

References 57 publications

(69 reference statements)

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“…Moreover, there was significant improvement of Sahaj Samadhi meditation on the Hamilton rating scale for depression in old patients during the COVID-19 period (110). Traditional Chinese herb formulations, such as Chaihu Shugan San, Xiaoyao San, and Sini San were proved to be effective to reduce depressive symptoms in patients infected with COVID-19 virus (111). Moreover, acupuncture was proofed not only to relief primary and secondary depressive symptoms, but also to reduce the side effects of the medical treatments (112).…”

Section: Complementary and Integrative Therapiesmentioning

confidence: 99%

Late-life depression: Epidemiology, phenotype, pathogenesis and treatment before and during the COVID-19 pandemic

Zhao

Tang³

et al. 2023

Front. Psychiatry

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Late-life depression (LLD) is one of the most common mental disorders among the older adults. Population aging, social stress, and the COVID-19 pandemic have significantly affected the emotional health of older adults, resulting in a worldwide prevalence of LLD. The clinical phenotypes between LLD and adult depression differ in terms of symptoms, comorbid physical diseases, and coexisting cognitive impairments. Many pathological factors such as the imbalance of neurotransmitters, a decrease in neurotrophic factors, an increase in β-amyloid production, dysregulation of the hypothalamic-pituitary-adrenal axis, and changes in the gut microbiota, are allegedly associated with the onset of LLD. However, the exact pathogenic mechanism underlying LLD remains unclear. Traditional selective serotonin reuptake inhibitor therapy results in poor responsiveness and side effects during LLD treatment. Neuromodulation therapies and complementary and integrative therapies have been proven safe and effective for the treatment of LLD. Importantly, during the COVID-19 pandemic, modern digital health intervention technologies, including socially assistive robots and app-based interventions, have proven to be advantageous in providing personal services to patients with LLD.

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Section: Complementary and Integrative Therapiesmentioning

confidence: 99%

Late-life depression: Epidemiology, phenotype, pathogenesis and treatment before and during the COVID-19 pandemic

Zhao

Tang³

et al. 2023

Front. Psychiatry

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“…As is well known, individuals remain in the workforce and have the highest psychological stress responses related to family, economic, and health issues in this stage of life [ 8 , 34 ]. It has also been found that music listening interventions or online music therapies have effects on reducing anxiety, enhancing mood, improving mental health, and supporting subjective wellbeing, not only for coping with diagnosed diseases but also for combating COVID-19-induced mood disturbance or mental stress [ 21 , 26 , 38 ]. Some types of music may actually increase negative emotions, although this differential effect of music has not yet been adequately tested.…”

Section: Discussionmentioning

confidence: 99%

Complementary and Alternative Medicines Used by Middle-Aged to Older Taiwanese Adults to Cope with Stress during the COVID-19 Pandemic: A Cross-Sectional Survey

Liu

Yeh

2022

Healthcare

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Background: This study aimed to investigate the factors influencing the use of complementary and alternative medicines (CAMs) to manage stress during the COVID-19 pandemic in Taiwan. Methods: A cross-sectional survey was administered to community-dwelling adults between the ages of 46 and 75 years, and a total of 351 participants completed the questionnaire. Log-binominal regression analyses were fitted to explore the factors associated with the use of CAMs. Results: The mean age of the participants was 57.0 years, and 67.0% reported that they had used CAMs within the past three months. Middle-aged adults were more likely to use CAMs than late middle-aged adults and older adults (p < 0.001). Overall, the major CAMs utilized to relieve psychological stress were music therapies (37.6%), massage (31.1%), spinal manipulation (25.1%), relaxing therapies (24.2%), and reading scriptures or The Bible (23.9%). Religion and vegetarian diets were the most important factors influencing participants to use CAMs, especially music therapies, massage, and reading scriptures/The Bible. Conclusions: CAM use was very prevalent among middle-aged adults in Taiwan; in particular, music therapies were the most favored activities for reducing stress. Population-specific mental health interventions using music can be developed to improve stress management outcomes during public health emergencies.

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“…[11] Accumulating evidence indicated the favorable therapeutic efficacy of traditional Chinese medicine in treating disease-induced depression, such as post-stroke depression, [12] chronic unpredictable mild stress-induced depression-like behaviors, [13] and COVID-19-induced depression. [14] Traditional Chinese medicine prescription is an effective, low-toxicity, multi-target prescription not only in the treatment of depression but also cancers. For example, a Chinese herbal formulation called Xiaoyao Kangai Jieyu Fang could ameliorate cancer-related depression concurrent with BC by promoting hippocampal synaptic plasticity.…”

Section: Introductionmentioning

confidence: 99%

Molecular basis of breast cancer with comorbid depression and the mechanistic insights of Xiaoyaosan in treating breast cancer-associated depression

Chen

2023

Medicine

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Depression and breast cancer (BC) have been found to have a shared genetic basis, multiple loci of effect, and a presumed causal relationship. The treatment of BC combined with depression poses significant challenges. This study aims to use bioinformatics and network pharmacology to explore the molecular basis of BC combined with depression and to elucidate the potential mechanisms of Xiaoyaosan (XYS) in treating this disease. The molecular background of BC complicated with depression was discovered via data mining and bioinformatics. The molecular mechanism of XYS in the treatment of BC with depression was investigated by network pharmacology. The binding affinity between targets and active compounds was evaluated by molecular docking. The impact of XYS on the gene and protein expression of matrix metallopeptidase 9 (MMP9) in microglial cells was assessed using RT-quantitative PCR and western blot analysis, respectively. Differential expression analysis was conducted to identify genes associated with BC, revealing that 2958 genes were involved, with 277 of these genes also being related to depression. XYS was found to contain 173 active compounds and 342 targets, with 44 of these targets being involved in regulating the progression of BC and depression. Enrichment analysis was performed to identify pathways associated with these targets, revealing that they were related to cell proliferation, catalytic activity, cell communication, and interleukin-18 signaling and LXR/RXR activation. Network analysis was conducted to identify key targets of Xiaoyaosan in treating BC combined with depression, with EGF, interleukin 6, epidermal growth factor receptor, and peroxisome proliferator activated receptor gamma being identified as important targets. Molecular docking was also performed to assess the binding affinity between key targets and active compounds, with puerarin showing the strongest affinity for MMP9. In microglial cells, XYS significantly enhances the gene and protein expression of MMP9. This study elucidated the pharmacological mechanism of co-treatment for BC patients complicated with depression and the pharmacological mechanism of XYS against BC plus depression.

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Potential therapeutic effect and methods of traditional Chinese medicine on COVID‐19‐induced depression: A review

Cited by 10 publications

References 57 publications

Late-life depression: Epidemiology, phenotype, pathogenesis and treatment before and during the COVID-19 pandemic

Late-life depression: Epidemiology, phenotype, pathogenesis and treatment before and during the COVID-19 pandemic

Complementary and Alternative Medicines Used by Middle-Aged to Older Taiwanese Adults to Cope with Stress during the COVID-19 Pandemic: A Cross-Sectional Survey

Molecular basis of breast cancer with comorbid depression and the mechanistic insights of Xiaoyaosan in treating breast cancer-associated depression

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