Potential therapeutic application of biophenols – plants secondary metabolites in rheumatoid arthritis

Mandal, Ashok Kumar; Sahoo, Ankit; Dwivedi, Khusbu; Singh, Richa; Kumar, Vikas

doi:10.1080/10408398.2022.2062700

Cited by 4 publications

(1 citation statement)

References 137 publications

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“…Further, it leads to bone erosion, destruction of articular cartilage, intense joint pain, swelling, and a high rate of disability [2]. Current statistics indicate that RA affects approximately 0.5% to 1% of the global population and the disease affects women more than men [3,4]. The cause of RA is unclear and may be related to genetic, environmental, and immunological factors [5].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Mechanism of Topical Application of Clematis Florida in the Treatment of Rheumatoid Arthritis through Network Pharmacology and Experimental Validation

Lei,

Jiang,

Zhao

et al. 2024

Preprint

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Clematis Florida (CF) is a folk medicinal herb in the southeast of China, which is traditionally used for treating osteoarticular diseases. However, the mechanism of action remains unclear. The present study used network pharmacology and experimental validation to explore the mechanism of CF in the treatment of rheumatoid arthritis (RA). Liquid chromatography-mass spectrometry (LC-MS/MS) identified 50 main compounds of CF, then the targets of them were obtained from TCMSP, ETCM, ITCM and Swiss TargetPrediction databases. RA disease related targets were obtained from DisGenet, OMIM and GeneCards databases. 99 overlapped targets were obtained using Venn diagram. The protein-protein interaction network (PPI)、the compound-target network (CT) and the compound-potential target genes-signaling pathways network (CPS) were built and analyzed. The results showed that the core compounds were screened as oleanolic acid, oleic acid, ferulic acid, caffeic acid, and syringic acid. And the core therapeutic targets were identified as PTGS2 (COX-2), MAPK1, NF-κB1, TNF, RELA by network pharmacology analysis, which belong to the MAPK signaling pathway and NF-κB signaling pathway. The animal experiments indicated that topical application of CF showed significant anti-inflammatory activity in mice model of xylene-induced ear edema and strong analgesic effect on acetic acid-induced withing. Furthermore, in the rat model of adjuvant arthritis (AA), topical administration of CF could alleviate toe swelling and ameliorate joint damage. The elevation of serum content of IL-6, COX-2, TNF-α, IL-1β, and RF caused by adjuvant arthritis were reduced by CF treatment. Western blotting tests showed that CF may exert regulation on the ERK and NF-κB pathway. The results provided a new perspective for the topical application of CF on RA.

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Section: Introductionmentioning

confidence: 99%

Exploring the Mechanism of Topical Application of Clematis Florida in the Treatment of Rheumatoid Arthritis through Network Pharmacology and Experimental Validation

Lei,

Jiang,

Zhao

et al. 2024

Preprint

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Isolation and Pharmacochemistry of  α-Mangostin as a Chemotherapeutic Agent

Meah,

Panichayupakaranant,

Sayeed

et al. 2024

Pharmacognosy Magazine

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A naturally occurring xanthone, mangostanin (1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9 H-xanthen-9-one), was isolated from Garcinia mangostana L. It demonstrates a range of pharmacological effects, such as antibacterial, antifungal, antiviral, anti-inflammatory, and anticancer activity. The α-mangostin’s isoprenyl and benzopyrone skeleton side chains are crucial to its antibacterial activity. In this review, we review the current approach for the isolation of α-mangostin from plant sources and the recent report on its biological activity. The structure–activity relationship is discussed to demonstrate the pharmacophore of α-mangostin responsible for its anti-infective properties, including antibacterial, antifungal, and antiviral activities. The potential approaches for developing α-mangostin for the treatment of infectious diseases are proposed as future perspectives.

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Secondary metabolites in topical infectious diseases and nanomedicine applications

Sahoo,

Dwivedi,

Almalki

et al. 2024

Nanomedicine

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Topical infection affects nearly one-third of the world's population; it may result from poor sanitation, hygienic conditions and crowded living and working conditions that accelerate the spread of topical infectious diseases. The problems associated with the anti-infective agents are drug resistance and long-term therapy. Secondary metabolites are obtained from plants, microorganisms and animals, but they are metabolized inside the human body. The integration of nanotechnology into secondary metabolites is gaining attention due to their interaction at the subatomic and skin-tissue levels. Hydrogel, liposomes, lipidic nanoparticles, polymeric nanoparticles and metallic nanoparticles are the most suitable carriers for secondary metabolite delivery. Therefore, the present review article extensively discusses the topical applications of nanomedicines for the effective delivery of secondary metabolites.

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Potential therapeutic application of biophenols – plants secondary metabolites in rheumatoid arthritis

Cited by 4 publications

References 137 publications

Exploring the Mechanism of Topical Application of Clematis Florida in the Treatment of Rheumatoid Arthritis through Network Pharmacology and Experimental Validation

Exploring the Mechanism of Topical Application of Clematis Florida in the Treatment of Rheumatoid Arthritis through Network Pharmacology and Experimental Validation

Isolation and Pharmacochemistry of  α-Mangostin as a Chemotherapeutic Agent

Secondary metabolites in topical infectious diseases and nanomedicine applications

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Potential therapeutic application of biophenols – plants secondary metabolites in rheumatoid arthritis

Cited by 4 publications

References 137 publications

Exploring the Mechanism of Topical Application of Clematis Florida in the Treatment of Rheumatoid Arthritis through Network Pharmacology and Experimental Validation

Exploring the Mechanism of Topical Application of Clematis Florida in the Treatment of Rheumatoid Arthritis through Network Pharmacology and Experimental Validation

Isolation and Pharmacochemistry of α-Mangostin as a Chemotherapeutic Agent

Secondary metabolites in topical infectious diseases and nanomedicine applications

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Isolation and Pharmacochemistry of  α-Mangostin as a Chemotherapeutic Agent