Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties

Guo, Xiong; Dong, Daifeng; Cheng, Chang; Jiang, Yali; Sun, Xiaoqiang; He, Jiayue; Li, Chuting; Gao, Yidian; Zhong, Xue; Zhao, Hanqing; Wang, Xiang; Yao, Shuqiao

doi:10.1016/j.nicl.2021.102871

Cited by 13 publications

(14 citation statements)

References 93 publications

(156 reference statements)

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“…In the analysis of group-level SCN, we did not detect any significant differences in inter-group comparisons. Despite prior investigations indicating group-level differences in structural covariance aberrance (Chen et al, 2022a;Neufeld et al, 2020;Singh et al, 2013;Watanabe et al, 2020;Xiong et al, 2021;Yun & Kim, 2021), our current study did not reveal any significant differences between patients with MDD and HCs. The inconsistent findings across studies may be attributed to factors such as small sample sizes in previous single-center investigations, comorbidities, medication, age of onset (Han et al, 2021;Schmaal et al, 2017).…”

Section: Discussioncontrasting

confidence: 99%

“…To date, the structural covariance network (SCN) has been commonly used to characterize the structural connectivity of gray matter morphology. Technically, traditional SCN, which was constructed from structural MRI by calculating interregional morphological similarity across a cohort of participants at the group level in a certain brain morphological measure, such as gray matter volume (GMV; Yao et al, 2010) or cortical thickness (He, Chen, & Evans, 2007), has been applied to identify abnormal alterations in the topological organization of the structural networks in MDD patients (Chen et al, 2022a; Singh et al, 2013; Xiong et al, 2021). Nevertheless, the population-based SCN not only neglects interindividual variability but cannot reveal the correlation between brain phenotype with clinical symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Altered topology of individual brain structural covariance networks in major depressive disorder

et al. 2023

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Background The neurobiological pathogenesis of major depression disorder (MDD) remains largely controversial. Previous literatures with limited sample size utilizing group-level structural covariance networks (SCN) commonly generated mixed findings regarding the topology of brain networks. Methods We analyzed T1 images from a high-powered multisite sample including 1173 patients with MDD and 1019 healthy controls (HCs). We used regional gray matter volume to construct individual SCN by utilizing a novel approach based on the interregional effect size difference. We further investigated MDD-related structural connectivity alterations using topological metrics. Results Compared to HCs, the MDD patients showed a shift toward randomization characterized by increased integration. Further subgroup analysis of patients in different stages revealed this randomization pattern was also observed in patients with recurrent MDD, while the first-episode drug naïve patients exhibited decreased segregation. Altered nodal properties in several brain regions which have a key role in both emotion regulation and executive control were also found in MDD patients compared with HCs. The abnormalities in inferior temporal gyrus were not influenced by any specific site. Moreover, antidepressants increased nodal efficiency in the anterior ventromedial prefrontal cortex. Conclusions The MDD patients at different stages exhibit distinct patterns of randomization in their brain networks, with increased integration during illness progression. These findings provide valuable insights into the disruption in structural brain networks that occurs in patients with MDD and might be useful to guide future therapeutic interventions.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Altered topology of individual brain structural covariance networks in major depressive disorder

et al. 2023

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“…50,51 Our finding of altered pulvinar connectivity in this mixed (both amnestic and nonamnestic) group is particularly noteworthy since several studies of depression have highlighted the role of the pulvinar in the pathophysiology of depression and also in the response to antidepressant therapy and remission. 35,52 Xiong et al identified decreased gray matter volume in the anterior pulvinar as a trait-marker of depression, 14 a phenomenon which was subsequently reversed with antidepressant therapy. 35,50 This was also suggested by novel connectivity data showing that decreased functional connectivity between the pulvinar and the parietal cortex and precuneus may be associated with memory impairments after electroconvulsive therapy in depressive patients .…”

Section: Descriptivesmentioning

confidence: 99%

The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder

Yulug,

Ayyildiz,

Sayman

et al. 2024

A&D Transl Res & Clin Interv

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INTRODUCTIONEmotionally driven cognitive complaints represent a major diagnostic challenge for clinicians and indicate the importance of objective confirmation of the accuracy of depressive patients’ descriptions of their cognitive symptoms.METHODSWe compared cognitive status and structural and functional brain connectivity changes in the pulvinar and hippocampus between patients with total depression and healthy controls. The depressive group was also classified as “amnestic” or “nonamnestic,” based on the members’ subjective reports concerning their forgetfulness. We then sought to determine whether these patients would differ in terms of objective neuroimaging and cognitive findings.RESULTSThe right pulvinar exhibited altered connectivity in individuals with depression with objective cognitive impairment, a finding which was not apparent in depressive patients with subjective cognitive impairment.DISCUSSIONThe pulvinar may play a role in depression‐related cognitive impairments. Connectivity network changes may differ between objective and subjective cognitive impairment in depression and may play a role in the increased risk of dementia in patients with depression.

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“…The results suggested that the remitted individuals demonstrated higher accuracy in identifying face emotions than the healthy individuals and the currently depressive individuals. On the other hand, trait-dependent abnormalities have also been reported for some psychophysical biomarkers (e.g., Chen et al, 2022;Douglas et al, 2012;Milders et al, 2010;Ruhe et al, 2019) and biological markers (e.g., Elliott et al, 2012;van der Vinne et al, 2019;van Eijndhoven et al, 2013;Xiong et al, 2021). For example, Milders et al (2010) investigated the stability of emotion recognition for patients with unipolar depression by a longitudinal design.…”

Section: Discussionmentioning

confidence: 99%

State‐dependent alterations of implicit emotional dominance during binocular rivalry in subthreshold depression

Qiu,

Luo,

Luo

et al. 2023

PsyCh Journal

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Binocular rivalry, a visual perception phenomenon where two or more percepts alternate every few seconds when distinct stimuli are presented to the two eyes, has been reported as a biomarker in several psychiatric disorders. It is unclear whether abnormalities of binocular rivalry in depression could occur when emotional rivaling stimuli are used, and if so, whether an emotional binocular rivalry test could provide a trait‐dependent or state‐dependent biomarker. In the current study, 34 individuals with subthreshold depression and 31 non‐depressed individuals performed a binocular rivalry task associated with implicit emotional processing. Participants were required to report their perceived orientations of the rival gratings in the foreground and to neglect emotional face stimuli in the background. The participants were retested after an approximately 4‐month time interval. Compared to the non‐depressed group, the subthreshold depression group showed significantly longer perceptual dominance durations of the grating with emotional faces as the background (i.e., implicit emotional dominance) at the initial assessment. However, the abnormality was not found at the follow‐up assessment. More importantly, we found smaller changes in depressive severity at the follow‐up assessment for individuals displaying longer emotional dominance at the initial assessment than for individuals with weaker emotional dominance. The current emotional binocular rivalry test may provide an objective, state‐dependent biomarker for distinguishing individuals with subthreshold depression from non‐depressed individuals.

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Potential structural trait markers of depression in the form of alterations in the structures of subcortical nuclei and structural covariance network properties

Cited by 13 publications

References 93 publications

Altered topology of individual brain structural covariance networks in major depressive disorder

Altered topology of individual brain structural covariance networks in major depressive disorder

The functional role of the pulvinar in discriminating between objective and subjective cognitive impairment in major depressive disorder

State‐dependent alterations of implicit emotional dominance during binocular rivalry in subthreshold depression

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