Potential sex differences in activation of pain-related brain regions in nonhuman primates with a unilateral spinal nerve ligation

Hama, Aldric; Murata, Kanae; Nozawa, Kenya; Matsushita, Masayuki; Yamashita, Aozora; Fujii, Rintaro; Awaga, Yuji; Natsume, Takahiro; Yoshida, Go; Matsuyama, Yukihiro; Takamatsu, Hiroyuki

doi:10.4103/1673-5374.371382

Cited by 2 publications

(2 citation statements)

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“…29,30 Besides, although improvement in motor features after INA delivery can be well assessed in animal models, the evaluation of non-motor functions such as mood, sleep conditions and cognition remains limited and requires further development. 31,32 (2) Multimodal real-time tracing system for precise assessment of INA delivery efficiency: Currently, the quantification of INA delivery efficiency primarily relies on mathematical modeling and tomographic slices. To advance our understanding, additional multimodal imaging technologies are needed for studying brain cell uptake and the real-time localization of drugs.…”

Section: Discussionmentioning

confidence: 99%

“…However, due to the anatomical and physiological differences among species (Table 2), there remains a gap between animal models and human clinical practice 29,30 . Besides, although improvement in motor features after INA delivery can be well assessed in animal models, the evaluation of non‐motor functions such as mood, sleep conditions and cognition remains limited and requires further development 31,32 …”

Section: Discussionmentioning

confidence: 99%

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Chances and challenges in intranasal administration delivery for brain disease treatment

Zheng,

Guo,

Yan

et al. 2023

Clinical and Translational Dis

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In order to overcome the formidable challenges posed by the intricate physiological barriers of the brain, the employment of intranasal administration (INA) has emerged as an unconventional method for drug delivery, offering distinct advantages such as non‐invasiveness and enhanced pharmacokinetic characteristics within the brain. Primarily exploiting the distinct conduit offered by the olfactory and/or trigeminal nerve systems, the INA route effectively delivers therapeutic agents. With introducing appropriate improvements to the drug formulation, such as the incorporation of nanocarriers, the efficacious delivery via the INA approach has gained considerable traction for the treatment of neurological disorders. This concise review highlights the notable progress in INA delivery and explores the potential therapeutic modalities inherent in this promising paradigm.

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