Potential roles of the rectum keystone microbiota in modulating the microbial community and growth performance in goat model

Abstract

Background Ruminal microbiota in early life plays critical roles in the life-time health and productivity of ruminant animals. However, understanding of the relationship between gut microbiota and ruminant phenotypes is very limited. Here, the relationship between the rectum microbiota, their primary metabolites, and growth rate of a total of 76 young dairy goats (6-month-old) were analyzed, and then 10 goats with the highest or lowest growth rates respectively were further compared for the differences in the rectum microbiota, metabolites, and animal’s immune parameters, to investigate the potential mechanisms by which the rectum microbiota contributes to the health and growth rate. Results The analysis of Spearman correlation and microbial co-occurrence network indicated that some keystone rectum microbiota, including unclassified Prevotellaceae, Faecalibacterium and Succinivibrio, were the key modulators to shape the rectum microbiota and closely correlated with the rectum SCFA production and serum IgG, which contribute to the health and growth rate of young goats. In addition, random forest machine learning analysis suggested that six bacterial taxa in feces could be used as potential biomarkers for differentiating high or low growth rate goats, with 98.3% accuracy of prediction. Moreover, the rectum microbiota played more important roles in gut fermentation in early life (6-month-old) than in adulthood stage (19-month-old) of goats. Conclusion We concluded that the rectum microbiota was associated with the health and growth rate of young goats, and can be a focus on the design of the early-life gut microbial intervention.

Dynamic effects of black soldier fly larvae meal on the cecal bacterial microbiota and prevalence of selected antimicrobial resistant determinants in broiler chickens

“…Interestingly, it has been shown that amendment of an obese-associated microbiome with the species Christensenellaceae minuta in mice, can reduce weight gain when subsequently transferred into germ-free mice [ 52 ]. As well, a higher prevalence of Christensenellaceae was found in goats with lower growth rates [ 53 ]. Taken together, the Christensenellaceae R-7 group bacteria may have significant implications modulating body weight of broiler chicken, which may, in turn, explain the reduced performance associated with a high BSFLM content diet.…”

Modulation of the rat intestinal microbiota in the course of Anisakis pegreffii infection

“…They are capable of producing various essential salts and fatty acids from dietary fiber, thereby playing a significant role in animal growth and development. Moreover, an increase in the abundance of the population of this group has been associated with the mitigation of gastric ulcer pathology (42)(43)(44)(45). The high weighted degree of centrality of this bacterial group in both the control and infected groups indicates its importance in the intestinal tract of both groups of test animals.…”

Astaxanthin, <i>Haematococcus pluvialis</i> and <i>Haematococcus pluvialis</i> Residue Alleviate Liver Injury in D-Galactose-induced Aging Mice through Gut-liver Axis

“…The results indicated the protective roles of the supplements on gut microbiota dysbiosis in aging mice. At genus levels, norank_f__Muribaculaceae 36) , Lactobacillus 37) , unclassified_f__Lachnospiraceae, norank_f__Lachnospiraceae 38) , Lachnospiraceae_ UCG-006 39) , Alistipes 40) , Streptococcus 41) , Rikenellaceae_ RC9_gut_group 42) , unclassified_f__Prevotellaceae 43) are SCFAs-producing bacteria, which are beneficial for liver health and are reported to be negatively associated with hepatic oxidative stress, inflammation and damage 44) . Norank_f__norank_o__Clostridia_UCG-014 45) , and Pre-votellaceae_UCG-001 46) are beneficial bacteria, that are reported to exert anti-inflammatory function and are inversely correlated with pro-inflammatory cytokines, like IL-6 and TNF-α.…”