Potential Roles of PTEN on Longevity in Two Closely Related Argopecten Scallops With Distinct Lifespans

Xu, Hanzhi; Lu, Xia; Wang, Chunde; Ning, Jing; Chen, Min; Wang, Yuan; Yuan, Ke

doi:10.3389/fphys.2022.872562

Cited by 5 publications

(4 citation statements)

References 60 publications

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“…Insulin/IGF-1 signaling (IIS), an evolutionarily conserved signaling pathway which has been known to play a key role in determination of animal lifespan for nearly three decades (Kenyon et al, 1993;Newell Stamper et al, 2018;An et al, 2019;Zhao et al, 2021), is one of the major pathways mediated by MEK1 in lifespan regulation. Numerous studies have demonstrated the importance of the PI3K/AKT/FoxO branch of IIS, and we have found it played a vital role in extending lifespan in Argopecten scallops (Wang et al, 2022;Xu et al, 2022). Previous studies also have identified an equally important role for Ras/Raf/MEK/ERK signaling cascade in IIS-dependent lifespan extension (LeRoith et al, 1995;Luckhart and Riehle, 2007).…”

Section: Introductionmentioning

confidence: 52%

“…The expression level of MEK1 in two scallop species were evaluated by quantitative real-time PCR (qRT-PCR) using specific qRT-PCR primers for MEK1 as listed in Table 1. The elongation factor EF-1a was chosen as the reference for internal standardization according to the previous study (Xu et al, 2022). Reactions were carried out on the QuantStudioTM 5 Real-Time PCR Instrument (Applied Biosystems) using SYBR green as fluorescent dye.…”

Section: Expression Profile Of Mek1 Gene In Two Argopecten Scallopsmentioning

confidence: 99%

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Potential roles of MEK1 on aging in Argopecten scallops

Yuan

Ning

et al. 2022

Front. Mar. Sci.

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Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) has been found to regulate aging through the Ras/Raf/MEK/ERK cascade in terrestrial animals. However, few reports have focused on MEK1 promoting aging in marine bivalves. In this study, we aimed to examine the potential roles of MEK1 in the regulation of aging in two Argopecten scallops, the bay scallop A. irradians and the Peruvian scallop A. purpuratus, which are closely related but with distinct lifespan. The complete ORFs of AiiMEK1 and ApuMEK1 were both 1209 bp, encoding 403 identical amino acids but with 41 synonymous SNPs, which may have contributed to the different activities of MEK1 in two scallops. Nutrient restriction, one of the most effective non-genetic means of promoting life span, significantly inhibit the expression of AiiMEK1 and ApuMEK1. The response in hepatopancreas of A. irradians to nutrient restriction was more persistently than that in A. purpuratus. RNAi of AiiMEK1 significantly increased the expression of its downstream genes known to favor longevity, such as FoxO and SOD, while decreased the expression of ERK1/2 and the key genes in the mTOR signaling pathway, as well as the β-GAL activity (a marker for senescence). These results indicated that AiiMEK1 may play a negative role in longevity through Ras/Raf/MEK/ERK pathway. Our results may provide new perspective for understanding of the conservative functions of MEK1 in regulation of aging in animals and benefit the genetic selection of scallops.

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Section: Introductionmentioning

confidence: 52%

Section: Expression Profile Of Mek1 Gene In Two Argopecten Scallopsmentioning

confidence: 99%

Potential roles of MEK1 on aging in Argopecten scallops

Yuan

Ning

et al. 2022

Front. Mar. Sci.

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“…Based on the obtained results, the most important genes included in the pathway were upregulated after long-distance delivery-PTEN (FC = 1.77), IRS2 (FC = 3.54), and SESN2 (FC = 5.11). The PTEN gene encodes a phosphatase and tensin homologue and is involved in the regulation of the cell cycle, preventing rapid cell growth and division (Xu et al, 2022). Several connections between physical exercise and PTEN expression have been shown in previous studies (Liu et al, 2012;Dashtiyan et al, 2017).…”

Section: Discussionmentioning

confidence: 90%

The modifications of Longevity Regulating Pathway resulting from endurance effort in Arabian horses

Myćka,

Ropka-Molik,

Cywińska

et al. 2024

Annals of Animal Science

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Recent studies have shown a highly positive effect of physical exercise on the overall condition of the body. The observed changes occur at the cellular level – proliferation, oxidative respiration, ROS degradation, whole-organism homeostasis improvement and ageing inhibition. The longevity regulating pathway is a broad term encompassing all the biochemical actions that contribute to keeping the organism in good condition and prolonging life duration. The overall aim of the present study was to describe the correlation between intensive physical activity and the expression of genes involved in biochemical processes related to longevity. A group of n=10 Arabian horses taking a part in an endurance ride for 120 km were included in the study. Blood samples from the horses were taken before and after the ride to perform comparative analyses of the transcriptome profiles. Using high-throughput NGS and bioinformatics tools, the group of 9 genes with the highest up- and downregulation fold change (FC) rates were identified: PTEN, IRS2, SESN2, CCND1, TBC1D1, FOXO1, KL, TP53, and SOD2. The results of this study could lead to the identification of a genetic marker for hot-blooded horse breeding.

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“…In BC, the PI3K over-activation is correlated with decreased phosphatase and tensin homolog deleted on chromosome ten (PTEN) expression that leads to activated and increased levels of AKT, thus promoting cell cycle progression [53]. Furthermore, PTEN is a tumor suppressor and a highly penetrant gene involved in hereditary predisposition to BC, which regulates and extends longevity through the inactivation of PI3K/AKT/FoxO pathway and maintenance of genome integrity in worms, flies, and mammals [54].…”

Section: Bc Is a Genomic Diseasementioning

confidence: 99%

Onco-Breastomics: An Eco-Evo-Devo Holistic Approach

Neagu,

Whitham,

Bruno

et al. 2024

IJMS

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Known as a diverse collection of neoplastic diseases, breast cancer (BC) can be hyperbolically characterized as a dynamic pseudo-organ, a living organism able to build a complex, open, hierarchically organized, self-sustainable, and self-renewable tumor system, a population, a species, a local community, a biocenosis, or an evolving dynamical ecosystem (i.e., immune or metabolic ecosystem) that emphasizes both developmental continuity and spatio-temporal change. Moreover, a cancer cell community, also known as an oncobiota, has been described as non-sexually reproducing species, as well as a migratory or invasive species that expresses intelligent behavior, or an endangered or parasite species that fights to survive, to optimize its features inside the host’s ecosystem, or that is able to exploit or to disrupt its host circadian cycle for improving the own proliferation and spreading. BC tumorigenesis has also been compared with the early embryo and placenta development that may suggest new strategies for research and therapy. Furthermore, BC has also been characterized as an environmental disease or as an ecological disorder. Many mechanisms of cancer progression have been explained by principles of ecology, developmental biology, and evolutionary paradigms. Many authors have discussed ecological, developmental, and evolutionary strategies for more successful anti-cancer therapies, or for understanding the ecological, developmental, and evolutionary bases of BC exploitable vulnerabilities. Herein, we used the integrated framework of three well known ecological theories: the Bronfenbrenner’s theory of human development, the Vannote’s River Continuum Concept (RCC), and the Ecological Evolutionary Developmental Biology (Eco-Evo-Devo) theory, to explain and understand several eco-evo-devo-based principles that govern BC progression. Multi-omics fields, taken together as onco-breastomics, offer better opportunities to integrate, analyze, and interpret large amounts of complex heterogeneous data, such as various and big-omics data obtained by multiple investigative modalities, for understanding the eco-evo-devo-based principles that drive BC progression and treatment. These integrative eco-evo-devo theories can help clinicians better diagnose and treat BC, for example, by using non-invasive biomarkers in liquid-biopsies that have emerged from integrated omics-based data that accurately reflect the biomolecular landscape of the primary tumor in order to avoid mutilating preventive surgery, like bilateral mastectomy. From the perspective of preventive, personalized, and participatory medicine, these hypotheses may help patients to think about this disease as a process governed by natural rules, to understand the possible causes of the disease, and to gain control on their own health.

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Potential Roles of PTEN on Longevity in Two Closely Related Argopecten Scallops With Distinct Lifespans

Cited by 5 publications

References 60 publications

Potential roles of MEK1 on aging in Argopecten scallops

Potential roles of MEK1 on aging in Argopecten scallops

The modifications of Longevity Regulating Pathway resulting from endurance effort in Arabian horses

Onco-Breastomics: An Eco-Evo-Devo Holistic Approach

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