Potential Roles of microRNAs in the Regulation of Monoamine Oxidase A in the Brain

Higuchi, Yuki; Soga, Tomoko; Parhar, Ishwar S.

doi:10.3389/fnmol.2018.00339

Cited by 13 publications

(11 citation statements)

References 108 publications

(142 reference statements)

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“…The hemolysis in serum was determined by the absorbance of hemoglobin at 414 nm (A414) using NanoDrop ND-1000 (Thermo Fisher Scientific, Waltham, MA, USA). Serum samples with absorbance ≤0.3 were considered as unhemolyzed [ 40 ], and stored at −80 °C until further purification ( Table S7 shows A414 for each sample).…”

Section: Methodsmentioning

confidence: 99%

Restraint Stress in Mice Alters Set of 25 miRNAs Which Regulate Stress- and Depression-Related mRNAs

Solich

Kuśmider

Faron-Górecka

et al. 2020

IJMS

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In the present study, we aim to identify the effect of restrain stress (RS) on the expression of miRNAs in mouse serum. We used three genotypes of animals (mice with knock-out of the gene-encoding norepinephrine transporter, NET-KO; C57BL/6J, and SWR/J) which had previously been shown to display different sensitivity to RS, and focused on miRNAs which were altered by RS in the serum of all three genotypes. An analysis of miRNAs expression allowed for the identification of a set of 25 differentially expressed miRNAs; 10 were down-regulated compared to an appropriate control group of animals, while 15 were up-regulated. The application of DIANA-miRPath v. 3.0 allowed for the identification of selected pathways (KEGG) and Gene Ontology (GO) categories that were significantly controlled by these miRNAs, while miRWalk v. 3.0—the platform that used the machine learning based algorithm, TaRPmiR—was used to find their targets. The results indicate that 25 miRNAs, identified as altered upon RS in three genotypes of mice, are responsible for regulation of mRNA-encoding proteins that are key for the main hypotheses of depression; therefore, they may help to understand the link between stress and depression at the molecular level.

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Section: Methodsmentioning

confidence: 99%

Restraint Stress in Mice Alters Set of 25 miRNAs Which Regulate Stress- and Depression-Related mRNAs

Solich

Kuśmider

Faron-Górecka

et al. 2020

IJMS

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“…Several miRNAs have been identified as important therapeutic targets involved in synaptic plasticity and neuro-development (27). The targeting of Ca 2+/ calmodulin kinase II (CaMKII) by miR-219 negatively regulates arsenic-induced hippocampus structural damage and the causes impairment of memory and learning (28).…”

Section: Introductionmentioning

confidence: 99%

miR‑134‑5p/Foxp2/Syn1 is involved in cognitive impairment in an early vascular dementia rat model

Liu

Zhang

et al. 2019

Int J Mol Med

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Forkhead box P2 (Foxp2) is a transcription factor involved in vocal learning. However, the number of previous studies that have investigated the role of Foxp2 in early vascular dementia (Vd) is limited. The aim of the present study was to determine whether microRNA (miR)-134-5p/Foxp2 contributes to cognitive impairment in a chronic ischemia-induced early Vd model. miR-134-5p was found to be significantly increased in the cortex in a rat Vd model. Intracerebroventricular injection of miR-134-5p antagomir into Vd rats prevented the loss of synaptic proteins and the development of cognitive impairment phenotypes. Histopathological analysis revealed that miR-134-5p aggravated cognitive impairment in Vd rats through damage to cortical neurons and loss of synaptic proteins. Bioinformatics analysis predicted that miR-134-5p targets Foxp2 mRNA. dual luciferase analysis and western blotting supported the prediction that miR-134-5p targets Foxp2. Furthermore, the silencing of Foxp2 significantly inhibited the effect of miR-134-5p on synaptic protein loss. chromatin immunoprecipitation-quantitative polymerase chain reaction analysis indicated that Foxp2 binds to the synapsin I (Syn1) promoter at-400/-600 bp upstream of the transcription start site. In conclusion, the miR-134-5p/Foxp2/Syn1 axis was found to contribute to cognitive impairment in a chronic ischemia-induced early Vd model, which may enable the development of new therapeutic strategies for the prevention and treatment of Vd.

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“…The time course of recovery of activity after smoking cessation extends over several weeks after smoking cessation, consistent with the equivalent recovery time from inhibition by known irreversible MAO inhibitory drugs ( Fowler et al, 2003 ). Although epigenetic ( Launay et al, 2009 ) and microRNA ( Higuchi et al, 2018 ) mechanisms for MAO activity reduction have been suggested, direct inhibition by components of tobacco smoke as the major cause of the observed reduction remains a likely mechanism by which MAO inhibition is accomplished in smokers.…”

Section: Monoamine Oxidase Inhibitorsmentioning

confidence: 99%

Biologically Active Compounds Present in Tobacco Smoke: Potential Interactions Between Smoking and Mental Health

et al. 2022

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Tobacco dependence remains one of the major preventable causes of premature morbidity and mortality worldwide. There are well over 8,000 compounds present in tobacco and tobacco smoke, but we do not know what effect, if any, many of them have on smokers. Major interest has been on nicotine, as well as on toxic and carcinogenic effects and several major and minor components of tobacco smoke responsible for the negative health effects of smoking have been elucidated. Smokers themselves report a variety of positive effects from smoking, including effects on depression, anxiety and mental acuity. Smoking has also been shown to have protective effects in Parkinson’s Disease. Are the subjective reports of a positive effect of smoking due to nicotine, of some other components of tobacco smoke, or are they a manifestation of the relief from nicotine withdrawal symptoms that smoking provides? This mini-review summarises what is currently known about the components of tobacco smoke with potential to have positive effects on smokers.

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Potential Roles of microRNAs in the Regulation of Monoamine Oxidase A in the Brain

Cited by 13 publications

References 108 publications

Restraint Stress in Mice Alters Set of 25 miRNAs Which Regulate Stress- and Depression-Related mRNAs

Restraint Stress in Mice Alters Set of 25 miRNAs Which Regulate Stress- and Depression-Related mRNAs

miR‑134‑5p/Foxp2/Syn1 is involved in cognitive impairment in an early vascular dementia rat model

Biologically Active Compounds Present in Tobacco Smoke: Potential Interactions Between Smoking and Mental Health

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