Potential roles of microRNAs and long noncoding RNAs as diagnostic, prognostic and therapeutic biomarkers in coronary artery disease

Jiang, Yong; Zhao, Ying; Li, Zhengyi; Chen, Shuang; Fang, Fang; Cai, Jianhui

doi:10.1016/j.ijcard.2023.03.067

Cited by 3 publications

(2 citation statements)

References 125 publications

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“…They extensively partake in umpteen genetic pathways ranging from cell proliferation to apoptosis, exhibiting a critical function in sustaining cell homeostasis. 18 For instance, miR-449a-5p suppresses the profile of CDK6 (cyclindependent kinase 6) to frustrate myocardial cell proliferation, indicating that it is an underlying target for myocardial damage prevention. 19 Bta-miR-885 targets MyoD1 (myogenic differentiation 1) to step up myoblast proliferation and differentiation, implying the indispensable role of Bta-miR-885 in bone development.…”

Section: Introductionmentioning

confidence: 99%

“…microRNAs (miRNAs) are known as small non‐coding RNAs modulating the profiles of genes. They extensively partake in umpteen genetic pathways ranging from cell proliferation to apoptosis, exhibiting a critical function in sustaining cell homeostasis 18 . For instance, miR‐449a‐5p suppresses the profile of CDK6 (cyclin‐dependent kinase 6) to frustrate myocardial cell proliferation, indicating that it is an underlying target for myocardial damage prevention 19 .…”

Section: Introductionmentioning

confidence: 99%

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The long non‐coding RNA maternally expressed 3‐micorRNA‐15a‐5p axis is modulated by melatonin and prevents nucleus pulposus cell inflammation and apoptosis

Zhang,

Qiu,

Yuan

2023

Basic Clin Pharma Tox

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Nucleus pulposus (NP) cell apoptosis is regarded as a critical risk factor for intervertebral disc degeneration (IVDD). Melatonin exerts a protective role on NP cells. The study concentrates on the role and mechanism of lncRNA MEG3 in melatonin‐mediated effects on NP cells. An in‐vitro IVDD model was constructed using IL‐1β on human NP cells. qRT‐PCR investigated MEG3, miR‐15a‐5p, and PGC‐1α mRNA levels in tissues and NP cells. IL‐1β treated NP cells subsequent to transfection, followed by melatonin treatment. NP cell proliferation, viability, apoptosis, and inflammatory reactions were assayed. Western blot checked the profiles of PGC‐1α, SIRT1, and NF‐κB p65. Student t‐test or one‐way analysis of variance (ANOVA) followed by Tukey's test were used for statistical tests. As indicated by the data, melatonin weakened NP cell inflammation and apoptosis and enhanced MEG3 expression. MEG3 expression was attenuated in IVDD tissues. MEG3 knockdown impaired the function of melatonin, which was, however, strengthened by miR‐15a‐5p knockdown. MEG3 targeted miR‐15a‐5p, which targeted PGC‐1α and repressed the PGC‐1α/SIRT1 pathway. Collectively, this study has disclosed that the MEG3‐miR‐15a‐5p‐PGC‐1α/SIRT1 pathway modulated by melatonin can hamper nucleus pulposus cell apoptosis and inflammation elicited by IL‐1β.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The long non‐coding RNA maternally expressed 3‐micorRNA‐15a‐5p axis is modulated by melatonin and prevents nucleus pulposus cell inflammation and apoptosis

Zhang,

Qiu,

Yuan

2023

Basic Clin Pharma Tox

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Non-coding RNAs in meningitis: Key regulators of immune response and inflammation

Imran,

Abida,

Kamal

et al. 2024

Pathology - Research and Practice

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The Significance of Genetically Determined Methylation and Folate Metabolism Disorders in the Pathogenesis of Coronary Artery Disease: A Target for New Therapies?

Pietruszyńska-Reszetarska,

Pietruszyński,

Irzmański

2024

IJMS

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Methylation is a biochemical process involving the addition of a methyl group (-CH3) to various chemical compounds. It plays a crucial role in maintaining the homeostasis of the endothelium, which lines the interior surface of blood vessels, and has been linked, among other conditions, to coronary artery disease (CAD). Despite significant progress in CAD diagnosis and treatment, intensive research continues into genotypic and phenotypic CAD biomarkers. This review explores the significance of the methylation pathway and folate metabolism in CAD pathogenesis, with a focus on endothelial dysfunction resulting from deficiency in the active form of folate (5-MTHF). We discuss emerging areas of research into CAD biomarkers and factors influencing the methylation process. By highlighting genetically determined methylation disorders, particularly the MTHFR polymorphism, we propose the potential use of the active form of folate (5-MTHF) as a novel CAD biomarker and personalized pharmaceutical for selected patient groups. Our aim is to improve the identification of individuals at high risk of CAD and enhance their prognosis.

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Potential roles of microRNAs and long noncoding RNAs as diagnostic, prognostic and therapeutic biomarkers in coronary artery disease

Cited by 3 publications

References 125 publications

The long non‐coding RNA maternally expressed 3‐micorRNA‐15a‐5p axis is modulated by melatonin and prevents nucleus pulposus cell inflammation and apoptosis

The long non‐coding RNA maternally expressed 3‐micorRNA‐15a‐5p axis is modulated by melatonin and prevents nucleus pulposus cell inflammation and apoptosis

Non-coding RNAs in meningitis: Key regulators of immune response and inflammation

The Significance of Genetically Determined Methylation and Folate Metabolism Disorders in the Pathogenesis of Coronary Artery Disease: A Target for New Therapies?

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