Potential roles of medicinal plants for the treatment of viral diseases focusing on <scp>COVID</scp>‐19: A review

Adhikari, Bikash; Marasini, Bishnu P.; Rayamajhee, Binod; Bhattarai, Bibek Raj; Lamichhane, Ganesh; Khadayat, Karan; Adhikari, Achyut; Khanal, Santosh; Parajuli, Niranjan

doi:10.1002/ptr.6893

Cited by 183 publications

(124 citation statements)

References 71 publications

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“…19 It causes the cells attacked by the virus to die and keeps the body stable. According to the literature, acacetin can inhibit the activity of SARS-CoV 3CL 20 and block the signal of IL-6 to reduce the level of IL-6 to play the role of antivirus activity, so as to reduce the lung injury of COVID-19. 21 It is reported that Isatidis Radix can reduce the level of IL-6 in inflammation caused by endotoxin, which further proves that component Radix Isatidis granule can be used to treat COVID-19.…”

Section: Discussionmentioning

confidence: 99%

Network Pharmacology Integrated Molecular Docking Reveals the Anti-COVID-19 and SARS Mechanism of Fufang Banlangen Keli

Cheng

Wang

Zhang

et al. 2021

Natural Product Communications

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Purpose Fufang Banlangen Keli (FBK) has been recommended for its clinical treatment of Coronavirus disease 2019 (COVID-19) and severe acute respiratory syndrome (SARS), but the mechanism of action is unclear. So, using network pharmacology and molecular docking, we studied the active components and mechanism of FBK in the treatment of COVID-19 and SARS. Methods The Encyclopedia of Traditional Chinese Medicine and Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform were used to screen the active components by oral bioactivity and drug likeness. Then, PharmMapper and SwissTargetPrediction databases were used to screen potential target genes of active components; the related target genes of COVID-19 and SARS were obtained from the GeneCards database. The intersection of the active components and disease-related targets was performed by the Venny2.1.0 database. The DAVID6.8 database and KOBAS3.0 database were used to get gene ontology (GO) function enrichment and Kyoto Encyclopedia of Genes and Genomes pathway annotation of gene targets. The “components-targets-pathways (C-T-P)” network of FBK was conducted by Cytoscape3.6.1 software. The top active components, angiotensin-converting enzyme 2 (ACE2) and SARS-CoV-2 3 Cl, were imported into AutoDock and PyMOL for molecular docking. Results From the FBK, a total of 28 active components and 73 gene targets were screened through network pharmacology. Twenty pathways were analyzed, including pathways in cancer, nod-like receptor signaling pathway, and pancreatic cancer, etc. ( P < 0.05). A total of 337 items were obtained by GO functional enrichment analysis ( P < 0.05), including 257 items for biological process, 38 items for cell composition, and 42 items for molecular function. Furthermore, molecular docking studies were performed to study potential binding between the key gene targets and selected active components. Conclusion Based on network pharmacology and molecular docking technology, qingdainone, (2Z)-2-(2-oxoindolin-3-ylidene) indolin-3-one, sinensetin, and acacetin in FBK were verified to bind to ACE2 and SARS-COV-2 3 Cl, so as to treat COVID-19 and SARS.

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Section: Discussionmentioning

confidence: 99%

Network Pharmacology Integrated Molecular Docking Reveals the Anti-COVID-19 and SARS Mechanism of Fufang Banlangen Keli

Cheng

Wang

Zhang

et al. 2021

Natural Product Communications

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“…It was found that NPs/SMs are a rich source of drug potential leads against coronaviruses due to their pronounced structural diversity and complexity. Several compilations of pre-2020 findings on NPs/SMs with activity against coronaviruses were recently reported, some of which could serve as leads for the development of new drugs [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. Among the identified molecules the majority is represented by NPs ( Figure 2 a) and most of them have been found as inhibitors of SARS-CoV ( Figure 2 b).…”

Section: Nps With Anti-hcov Potentialmentioning

confidence: 99%

Natural and Nature-Derived Products Targeting Human Coronaviruses

et al. 2021

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The ongoing pandemic of severe acute respiratory syndrome (SARS), caused by the SARS-CoV-2 human coronavirus (HCoV), has brought the international scientific community before a state of emergency that needs to be addressed with intensive research for the discovery of pharmacological agents with antiviral activity. Potential antiviral natural products (NPs) have been discovered from plants of the global biodiversity, including extracts, compounds and categories of compounds with activity against several viruses of the respiratory tract such as HCoVs. However, the scarcity of natural products (NPs) and small-molecules (SMs) used as antiviral agents, especially for HCoVs, is notable. This is a review of 203 publications, which were selected using PubMed/MEDLINE, Web of Science, Scopus, and Google Scholar, evaluates the available literature since the discovery of the first human coronavirus in the 1960s; it summarizes important aspects of structure, function, and therapeutic targeting of HCoVs as well as NPs (19 total plant extracts and 204 isolated or semi-synthesized pure compounds) with anti-HCoV activity targeting viral and non-viral proteins, while focusing on the advances on the discovery of NPs with anti-SARS-CoV-2 activity, and providing a critical perspective.

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“…It can promote the expression and activity of detoxifying enzymes [ 7 ], and prevent the toxic effects of polycyclic aromatic hydrocarbons [ 14 ]. Lastly, daidzein can assist with the treatment of viral infections, including COVID-19 [ 17 ].…”

Section: Physiological and Therapeutic Actions Of Daidzein And Its Metabolite Equolmentioning

confidence: 99%

The Influence of Plant Isoflavones Daidzein and Equol on Female Reproductive Processes

2021

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In this review, we explore the current literature on the influence of the plant isoflavone daidzein and its metabolite equol on animal and human physiological processes, with an emphasis on female reproduction including ovarian functions (the ovarian cycle; follicullo- and oogenesis), fundamental ovarian-cell functions (viability, proliferation, and apoptosis), the pituitary and ovarian endocrine regulators of these functions, and the possible intracellular mechanisms of daidzein action. Furthermore, we discuss the applicability of daidzein for the control of animal and human female reproductive processes, and how to make this application more efficient. The existing literature demonstrates the influence of daidzein and its metabolite equol on various nonreproductive and reproductive processes and their disorders. Daidzein and equol can both up- and downregulate the ovarian reception of gonadotropins, healthy and cancerous ovarian-cell proliferation, apoptosis, viability, ovarian growth, follicullo- and oogenesis, and follicular atresia. These effects could be mediated by daidzein and equol on hormone production and reception, reactive oxygen species, and intracellular regulators of proliferation and apoptosis. Both the stimulatory and the inhibitory effects of daidzein and equol could be useful for reproductive stimulation, the prevention and mitigation of cancer development, and the adverse effects of environmental stressors in reproductive biology and medicine.

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Potential roles of medicinal plants for the treatment of viral diseases focusing on COVID‐19: A review

Cited by 183 publications

References 71 publications

Network Pharmacology Integrated Molecular Docking Reveals the Anti-COVID-19 and SARS Mechanism of Fufang Banlangen Keli

Network Pharmacology Integrated Molecular Docking Reveals the Anti-COVID-19 and SARS Mechanism of Fufang Banlangen Keli

Natural and Nature-Derived Products Targeting Human Coronaviruses

The Influence of Plant Isoflavones Daidzein and Equol on Female Reproductive Processes

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