Potential Roles of Innate Immune Chemokine and Cytokine Network on Lipopolysaccharide-Based Therapeutic Approach in Ovarian Cancer

Ignacio, Rosa Mistica C.; Lee, Eun-Sook; Son, Deok‐Soo

doi:10.4110/in.2019.19.e22

Cited by 8 publications

(6 citation statements)

References 45 publications

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“…Interestingly, Ihnba showed a high expression exclusively in peritoneal macrophages (data not shown). A recent report found that LPS treatment improved the innate immunity in a xenograft model of SKOV3 cells in CD-1 mice, resulting in extended survival and increased CXCL1 levels [31], one of the chemokines that was also detected here at higher levels in multiparous mice ( Figure 4A).…”

Section: Parity-dependent Serum Cytokine Levels and Correlation With supporting

confidence: 54%

The Ovarian Transcriptome of Reproductively Aged Multiparous Mice: Candidate Genes for Ovarian Cancer Protection

et al. 2020

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In middle-aged women, the decline of ovarian follicle reserve below a critical threshold marks menopause, leading to hormonal, inflammatory, and metabolic changes linked to disease. The highest incidence and mortality of sporadic ovarian cancer (OC) occur at post-menopause, while OC risk is reduced by full-term pregnancies during former fertile life. Herein, we investigate how parity history modulates the ovarian transcriptome related to such declining follicle pool and systemic inflammation in reproductively-aged mice. Female C57BL/6 mice were housed under multiparous and virgin (nulliparous) breeding regimens from adulthood until estropause. The ovaries were then subjected to follicle count and transcriptional profiling, while a cytokine panel was determined in the sera. As expected, the follicle number was markedly decreased just by aging. Importantly, a significantly higher count of primordial and total follicles was observed in aged multiparous relative to aged virgin ovaries. Consistently, among the 65 genes of higher expression in aged multiparous ovaries, 27 showed a follicle count-like pattern, 21 had traceable evidence of roles in follicular/oocyte homeostasis, and 7 were transforming-growth factor beta (TGF-β)/bone morphogenetic protein (BMP) superfamily members. The remaining genes were enriched in cell chemotaxis and innate-immunity, and resembled the profiles of circulating CXCL1, CXCL2, CXCL5, CSF3, and CCL3, chemokines detected at higher levels in aged multiparous mice. We conclude that multiparity during reproductive life promotes the retention of follicle remnants while improving local (ovarian) and systemic immune-innate surveillance in aged female mice. These findings could underlie the mechanisms by which pregnancy promotes the long-term reduced OC risk observed at post-menopause.

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Section: Parity-dependent Serum Cytokine Levels and Correlation With supporting

confidence: 54%

The Ovarian Transcriptome of Reproductively Aged Multiparous Mice: Candidate Genes for Ovarian Cancer Protection

et al. 2020

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“…On the one hand, studies using LPS in immunocompetent, immune-system-intact animals show inoculation regimes are quite effective in reducing tumor burden (ovarian, liver, glioma etc.) ( Ignacio et al, 2019 ; Okuyama et al, 2017 ; Won et al, 2003 ), coinciding with significant changes in boosting of immune function ( Chicoine et al, 2001 ; Chicoine et al, 2007 ). LPS has also been shown to lessen the side effects of antibiotics and chemotherapies ((e.g., LPS or gram-negative microbes (e. g., Alistipes shahii ) ( Soma and Inagawa, 2015 ) and oral administration e. g. ( Pantoea agglomerans ) establishes complete recovery and remission in 62 % of patients ( Morishima and Inagawa, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Functional immune boosters; the herb or its dead microbiome? Antigenic TLR4 agonist MAMPs found in 65 medicinal roots and algae’s

Mazzio,

Barnes,

Badisa

et al. 2023

Journal of Functional Foods

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“…The RP105/MD‐1 complex mediates the response to lipopolysaccharide (LPS), similar to TLR4, and promotes pathological and physiological regulation of the innate immune system and inflammation . It was reported that LPS significantly increased the mean survival time in the murine peritoneal dissemination model of SKOV‐3 ovarian cells, likely through potentiation of the cytotoxic‐related innate immunogenicity via proinflammatory chemokines . With the development of molecular immunology, immunotherapy is becoming an attractive therapeutic strategy for OS treatment .…”

Section: Discussionmentioning

confidence: 99%

A risk signature‐based on metastasis‐associated genes to predict survival of patients with osteosarcoma

Shi

Zhuang

et al. 2020

J of Cellular Biochemistry

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Osteosarcoma (OS) is the most common primary solid malignant bone tumor, and its metastasis is a prominent cause of high mortality in patients. In this study, a prognosis risk signature was constructed based on metastasis-associated genes. Four microarrays datasets with clinical information were downloaded from Gene Expression Omnibus, and 256 metastasis-associated genes were identified by limma package. Further, a protein-protein interaction network was constructed, and survival analysis was performed using data from the Therapeutically Applicable Research to Generate Effective Treatments data matrix, identifying 19 genes correlated with prognosis. Six genes were selected by the least absolute shrinkage and selection operator regression for multivariate cox analysis. Finally, a three-gene (MYC, CPE, and LY86) risk signature was constructed, and datasets GSE21257 and GSE16091 were used to validate the prediction efficiency of the signature. The survival times of low-and highrisk groups were significantly different in the training set and validation set.Additionally, gene set enrichment analysis revealed that the genes in the signature may affect the cell cycle, gap junctions, and interleukin-6 production. Therefore, the three-gene survival risk signature could potentially predict the prognosis of patients with OS. Further, proteins encoded by CPE and LY86 may provide novel insights into the prediction of OS prognosis and therapeutic targets.differentially expressed genes, metastasis, osteosarcoma, risk signature, survival analysis 1 | INTRODUCTION Osteosarcoma (OS), characterized by malignant mesenchymal cells producing an osteoid matrix and fibrillary stroma, is the most common osseous aggressive cancer in children and juveniles and commonly arises at the terminus of the long bones, including distal femurs, proximal tibias, and proximal humor. 1 According to the National Cancer Institute Surveillance, Epidemiology, and End Results program, the frequency of OS has increased by 0.3% per year over the last decade. 2 With the intensification of chemotherapeutic regimens, the 5-year survival rate of OS patients without metastasis has been improved to 60%-70%. 3 By contrast, the survival rate is only 0%-30% in patients with OS with metastasis, 4 indicating that OS metastasis is associated poor longterm prognosis. However, metastasis-associated molecules Yi Shi and Ronghan He contributed equally to this work.

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Potential Roles of Innate Immune Chemokine and Cytokine Network on Lipopolysaccharide-Based Therapeutic Approach in Ovarian Cancer

Cited by 8 publications

References 45 publications

The Ovarian Transcriptome of Reproductively Aged Multiparous Mice: Candidate Genes for Ovarian Cancer Protection

The Ovarian Transcriptome of Reproductively Aged Multiparous Mice: Candidate Genes for Ovarian Cancer Protection

Functional immune boosters; the herb or its dead microbiome? Antigenic TLR4 agonist MAMPs found in 65 medicinal roots and algae’s

A risk signature‐based on metastasis‐associated genes to predict survival of patients with osteosarcoma

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