Potential role of vitamin K in radiological progression of early knee osteoarthritis patients

El-Brashy, Abdel Wahab Sh. E.; Eltanawy, Refaat; Hassan, Waleed; Shaban, Howyda M.; Bhnasawy, Menna Mi

doi:10.1016/j.ejr.2016.03.001

Cited by 17 publications

(7 citation statements)

References 36 publications

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“…On the other hand, adequate vitamin K (≥ 90 µg/day for women or 120 µg/day for men) and D intake (≥ 600 IU for age < 70 years, ≥ 800 IU for age ≥ 70 years) were associated with overall 20-m gait speed and chair stand completion time, on follow-up, but not in the 400-m walk time [37]. In another study, subjects with vitamin K deficiency also showed higher pain scores on The Western Ontario McMaster Scale Scores, after 12 months follow-up study [25].…”

Section: Prospective Studiesmentioning

confidence: 92%

“…In the Health ABC Study, plasma vitamin K level below detection at baseline predicted articular cartilage and meniscus damage among community-dwelling elderly after three years [34]. Similarly, El-Brashy et al [25] showed that baseline vitamin K deficiency (as indicated by the plasma phylloquinone level) was associated with significantly decreased cartilage thickness at medial, lateral, and sulcus condyles, as revealed by ultrasound assessment, as well as OA progression.…”

Section: Prospective Studiesmentioning

confidence: 95%

“…Increased plasma phylloquinone level was linked to increased medial cartilage thickness. Subjects with vitamin K deficiency was found to have higher scores of Western Ontario McMaster Scale (WOMAC), which reflects an increased severity of the disease [25].…”

Section: Case-control Studiesmentioning

confidence: 99%

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The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence

Chin

2020

Nutrients

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Vitamin K is a cofactor of γ-glutamyl carboxylase, which plays an important role in the activation of γ-carboxyglutamate (gla)-containing proteins that negatively regulate calcification. Thus, vitamin K status might be associated with osteoarthritis (OA), in which cartilage calcification plays a role in the pathogenesis of the disease. This review collates the evidence on the relationship between vitamin K status (circulating or dietary intake level of vitamin K, or circulating uncarboxylated gla proteins) and OA from human observational studies and clinical trial, to examine its potential as an agent in preventing OA. The current literature generally agrees that a sufficient level of vitamin K is associated with a lower risk of OA and pathological joint features. However, evidence from clinical trials is limited. Mechanistic study shows that vitamin K activates matrix gla proteins that inhibit bone morphogenetic protein-mediated cartilage calcification. Gla-rich proteins also inhibit inflammatory cascade in monocytic cell lines, but this function might be independent of vitamin K-carboxylation. Although the current data are insufficient to establish the optimal dose of vitamin K to prevent OA, ensuring sufficient dietary intake seems to protect the elderly from OA.

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Section: Prospective Studiesmentioning

confidence: 92%

Section: Prospective Studiesmentioning

confidence: 95%

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The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence

Chin

2020

Nutrients

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“…Knees are the most commonly affected joints by primary OA [5], and it was reported that radiographic progression has been detected even with early Knee OA (KOA) involvement in Egyptian patients [6,7]. Chronic inflammation accompanied by angiogenesis play an important role in the pathophysiology of osteoarthritis and affect disease progression [2,8].…”

Section: Introductionmentioning

confidence: 99%

Synovial fluid level of vascular endothelial growth factor (VEGF) can predict functional status and radiological severity in patients with knee osteoarthritis (OA)

Abdel-Magied¹,

AbuOmar²,

Higazi³

et al. 2019

Int. J. Clin. Rheumatol

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Aim of the work: Detection of serum and synovial fluid level of Vascular Endothelial Growth Factor (VEGF) in patients with knee osteoarthritis (OA) and to determine its relation to radiological severity and function status. Patients and methods: Thirty OA patients and thirty controls were included. Function status was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Knee pain evaluated using the Visual Analogue Scale (VAS). Serum and synovial fluid level of VEGF were measured. Kellgren-Lawrence grading scale (KL) used to assess radiological severity. Results: The mean of patients' age was 50.33 ± 5.3 years (20 females and 10 males) with disease duration of 7.03 ± 2.12 years. Mean synovial fluid VEGF of OA patients was 964.1 ± 396.72, mean serum VEGF of OA patients was 219.1 ± 96.95. No difference between serum VEGF of patients and control groups (p=0.787). Significant positive correlation between serum and synovial VEGF in OA patients (r=0.58, p=0.001). Significant positive correlation between the synovial fluid VEGF and patients' age, disease duration, inactivity stiffness, ESR, VAS, WOMAC and KL grade scale (p‹0.0001,p=0.029,p‹0.0001,p‹0.0001,p=0.00 3,p‹0.0001,p‹0.0001). Significant positive correlation between serum VEGF and patients' age, inactivity stiffness, WOMAC, ESR and KL grade scale (p‹0.0001, p=0.005, p=0.001, p=0.001,p=0.010). Synovial fluid VEGF was the significant predictors for determining the function status (p‹0.0001); while for determining severity; synovial fluid VEGF, patients' age and VAS were significant predictors (p‹0.0001,p=0.001 and p=0.029 respectively). Conclusion: Serum and synovial fluid VEGF correlated with the clinical features, functional status and radiological features of Knee OA. Synovial VEGF can predict both functional impact and radiological severity in patients with knee OA.

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“…As a result, read alignments may be erroneous particularly at genomic regions that differ substantially between the sequenced individual and the reference sequence, thus introducing reference allele bias, flawed genotypes, and false-positive variant discovery around indels [25][26][27]. Aligning reads to population-or breed-specific reference genomes may overcome most of these limitations [28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Accurate sequence variant genotyping in cattle using variation-aware genome graphs

Crysnanto

Wurmser

Pausch

2018

Preprint

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Background:The genotyping of sequence variants typically involves as a first step the alignment of sequencing reads to a linear reference genome. Because a linear reference genome represents only a small fraction of sequence variation within a species, reference allele bias may occur at highly polymorphic or diverged regions of the genome. Graph-based methods facilitate to compare sequencing reads to a variation-aware genome graph that incorporates a collection of non-redundant DNA sequences that segregate within a species.We compared accuracy and sensitivity of graph-based sequence variant genotyping using the Graphtyper software to two widely used methods, i.e., GATK and SAMtools, that rely on linear reference genomes using whole-genomes sequencing data of 49 Original Braunvieh cattle. Results:We discovered 21,140,196, 20,262,913 and 20,668,459 polymorphic sites using GATK, Graphtyper, and SAMtools, respectively. Comparisons between sequence variant and microarray-derived genotypes showed that Graphtyper outperformed both GATK and SAMtools in terms of genotype concordance, non-reference sensitivity, and non-reference discrepancy. The sequence variant genotypes that were obtained using Graphtyper had the lowest number of mendelian inconsistencies for both SNPs and indels in nine sire-son pairs with sequence data. Genotype phasing and imputation using the Beagle software improved the quality of the sequence variant genotypes for all tools evaluated particularly for animals that have been sequenced at low coverage. Following imputation, the concordance between sequence-and microarray-derived genotypes was almost identical for the three methods evaluated, i.e., 99.32, 99.46, and 99.24 % for GATK, Graphtyper, and SAMtools, respectively. Variant filtration based on commonly used criteria improved the genotype concordance slightly but it also decreased sensitivity. Graphtyper required considerably more computing resources than SAMtools but it required less than GATK.Conclusions: Sequence variant genotyping using Graphtyper is accurate, sensitive and computationally feasible in cattle. Graph-based methods enable sequence variant genotyping from variation-aware reference genomes that may incorporate cohort-specific sequence variants which is not possible with the current implementations of state-of-the-art methods that rely on linear reference genomes.

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Potential role of vitamin K in radiological progression of early knee osteoarthritis patients

Cited by 17 publications

References 36 publications

The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence

The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence

Synovial fluid level of vascular endothelial growth factor (VEGF) can predict functional status and radiological severity in patients with knee osteoarthritis (OA)

Accurate sequence variant genotyping in cattle using variation-aware genome graphs

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