Potential role of tinospora cordifolia in management of COVID-19

Abstract

Background: Tinospora cordifolia has gained popularity as an immunomodulatory and protective herb. Being anIndian traditional herb, it has found its use in Ayurveda and alternative system of medicine. According to World Health Organization, still 80% of the world population relies on alternative therapies for disease and infirmity. Dearth of medicine and treatment for COVID-19 has pushed researcher towards alternative therapies. This review focuses on the potential role of T.cordifolia in management of Coronavirus disease. Methods:A systematic review has been carried out by searching Google Scholar and SCOPUS Database from the year 2020 onwards. The review is written following the PRISMA Guidelines. Results:A total of 20 studies have been included in the systematic review. These studies are mainly based on molecular docking (in-silico studies), narrative reviews, retrospective studies, animal experimentation and randomized controlled trials. All the studies reported promising results. In silico studies covered the activity of phytochemicals in T.cordifolia and their inhibitory action on viral replication and binding. The experimental studies also showed positive results in human as well as animal models.