Potential Role of Selected Biomarkers for Predicting the Presence and Extent of Coronary Artery Disease

Gřiva, Martin; Náplava, Robert; Špendlíková, Milada; Jarkovský, Jiří; Hlinomaz, Ota; Cíhalík, C

doi:10.5507/bp.2010.033

Cited by 8 publications

(6 citation statements)

References 34 publications

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“…After this period, coronary death due to IHD, is the leading cause of the long-term mortality in IS patients, with an incidence of 1.5-5.4% [31]. Consequently, excessive efforts are dedicated to IHD identification and its proper management [32]. The majorities of initial presentations of CVD are neither AMI nor IS, yet most primary prevention studies focus on these presentations.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Associated with Acute Coronary Syndrome in Northern Saudi Arabia

2017

JCCR

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Objective: The aim of this study was to find out the common risk factors associated with Acute Coronary Syndrome (ACS) in Northern Kingdom of Saudi Arabia (KSA).Methodology: One hundred and fifty six patients with ACS were investigated in intensive care unit (ICU), at cardiac center in King Khalid Hospital, in northern KSA, city of Hail.Results: Risk factors for ACS including; Hypertension, Ischemic Heart Disease (IHD), Smoking, Diabetes Miletus (DM), and Dyslipidemia were found in 68.6%, 34.6%, 20.5%, 59% and 83.3% of the patients, respectively. Conclusion:The most common risk factors for ACS in northern KSA (Hail region) were dyslipidemia and hypertension. These favored the urgent need for intervention and control, which lower the burden of ACS.

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Section: Discussionmentioning

confidence: 99%

Risk Factors Associated with Acute Coronary Syndrome in Northern Saudi Arabia

2017

JCCR

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“…Since inflammation plays an important role in the pathophysiologic process of atherosclerosis, circulatory inflammatory factors could be used as predictors of coronary artery disease (23). Inflammatory cytokines tested here are often applied to predict coronary artery disease and are considered to de associated with vulnerable atherosclerotic plaque.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Free Testosterone and Inflammatory Cytokines in Old Men with Acute Coronary Syndrome

Gao¹

2011

Acta Endo (Buc)

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As men are aging, their testosterone levels decline, while the morbidity of atherosclerosis (AS) rises in accordance with their age. Recent studies indicate that inflammation contributes to atherosclerosis. Whether hypogonadism in old men is associated with inflammation deserves to be investigated.Background. To examine the relationship between free testosterone (FT) and inflammatory cytokines such as pregnancy-associated plasma protein A (PAPP-A), interleukin-6 (IL-6), vascular cell adhesion molecule-1 (VCAM-1), intracellular adhesion factor-1 (ICAM-1) in old men with acute coronary syndrome (ACS).Methods. Serum was collected from 107 men aged 60-86 years. Among them, 52 were patients with ACS. The relationships between FT and PAPP-A, IL-6, VCAM-1 and ICAM-1 were examined respectively.Results. Levels of weight, body mass index, total cholesterol, low density lipoprotein cholesterol, triglyceride, PAPP-A, IL-6, VCAM-1 and ICAM-1 of old male ACS patients were higher than those of controls; FT and high density lipoprotein cholesterol levels were lower than those of controls. FT level was inversely associated with PAPP-A, IL-6, VCAM-1 and ICAM-1. Conclusions. FT level is inversely associated with inflammatory cytokines such as PAPP-A, IL-6, VCAM-1 and ICAM-1 in old men with ACS. This might imply that low testosterone is associated with inflammation in old men with ACS.

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“…In the present study, the diagnosis of IHD was based upon clinical and ECG findings, as used in everyday clinical practice, not on the basis of radiological findings, such as coronarography, as used in previous studies [7][8][9][10] or laboratory findings as emerging studies suggest. Coronarography is a very sensitive and specific method for evaluation of degree of coronary stenosis.…”

Section: Discussionmentioning

confidence: 99%

“…(ref [2][3][4][5] ). Thus, a great deal of effort is devoted to IHD identification and its proper management [6][7][8] . It is not clear to date, why IHD is present only in some IS patients and not in others 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Risk factors associated with ischemic heart disease occurence in acute ischemic stroke patients

Kováčik¹,

Madarasz²,

Král³

et al. 2013

BIOMED PAP

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Aims. At specific time periods following ischemic stroke (IS), acute coronary syndrome as ischemic heart disease (IHD) represents a higher risk of death than IS. Not all IS patients can undergo specific examination for IHD detection. The aim of this study was to assess exclusive risk factors (RFs) associated with IHD occurrence in IS patients. Knowledge of these RFs should help in stratifying IS patients for IHD detection. Materials and methods. This was a hospital-based, retrospective, single centre study. The sample consisted of 192 consecutive IS patients, divided into two subgroups -Subgroup 1 (54 patients without IHD; 55.6% males; 63.1 ± 11.8 years) and Subgroup 2 (138 patients with IHD; 39.1% males; 76.3 ± 9.6 years). The following factors were identified: age; sex; presence of arterial hypertension, atrial fibrillation, diabetes mellitus; plasma levels of total cholesterol, triglycerides, low-density cholesterol, high-density cholesterol; body mass index; presence of carotid plaques. Logistic regression analysis was used for statistical evaluation. Results. Of all identified risk factors only age (OR=1.109; 95% CI: 1.069 -1.150, P=0.001) and the presence of arterial hypertension (OR=6.298; 95% CI: 2.215 -17.905, P=0.003) were exclusively and significantly associated with the presence of IHD in IS patients. Conclusions. Age and arterial hypertension may be exclusive risk factors associated with IHD in IS patients.

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Potential Role of Selected Biomarkers for Predicting the Presence and Extent of Coronary Artery Disease

Cited by 8 publications

References 34 publications

Risk Factors Associated with Acute Coronary Syndrome in Northern Saudi Arabia

Risk Factors Associated with Acute Coronary Syndrome in Northern Saudi Arabia

Relationship Between Free Testosterone and Inflammatory Cytokines in Old Men with Acute Coronary Syndrome

Risk factors associated with ischemic heart disease occurence in acute ischemic stroke patients

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