Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatment

Liyis, Bryan Gervais de; Halim, Wilson; Widyadharma, I Putu Eka

doi:10.1186/s41983-022-00487-5

Cited by 4 publications

(1 citation statement)

References 56 publications

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“…Recent research indicates that neurodegenerative diseases have increased in prevalence in recent years [44,45] due to pesticides effects [46][47][48]. Specifically, the etiology of Alzheimer's disease remains unclear and the role of the environment as a probable risk factor is significant [38, [49][50][51], nevertheless, some new treatments has been suggested for this affection, at least in vitro [52][53][54][55]. Of particular concern is the evidence suggesting that prenatal and postnatal exposures to harmful environmental factors predispose individuals to neurodegenerative diseases later in life [56].…”

Section: Ad and Pesticidesmentioning

confidence: 99%

The Indiscriminate Use of Pesticides could Increase the Prevalence of Alzheimer's Disease? A Systematic Review

Trevisan,

Cristina-Pereira,

Santos

et al. 2024

Int. Neuropsy. Dis. J.

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Aims: This review aims to perform an extensive literature search about the pesticides problems and to associate with AD in qualitative analysis, mainly. Place and Duration of Study: Biomathematics Laboratory, Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas, Brazil. Entre outubro de 2023 a abril de 2024. Methodology: For the purpose of this systematic review, articles from 2014 onwards with the descriptors Alzheimer's disease and pesticides; neurodegenerative diseases and pesticides, were sought. Among these, articles considered most pertinent to the objective of the present review were utilized, i.e., those whose subject matter was associated with the effects of pesticides, especially glyphosate, on dementias, particularly Alzheimer’s disease (AD). Results: After analyzed 35,590 articles, and applying exclusion criteria to journals with an impact factor equal to or lower than 4 and including topics most relevant to the objectives of this work, 35,526 articles were excluded, resulting in 64 remaining articles, of which 40 were qualitative in scope and 24 were quantitative. The articles considered most suitable for the objective of the present review were utilized, i.e., those whose topic was associated with the effects of pesticides, especially glyphosate, on dementia. The criteria for scrutinizing articles included a journal impact factor equal to or greater than 4 and the removal of duplicate articles using the freely accessible EndNote program from Web of Science. Articles and books on history and those outside the scope of the pesticide/AD relationship did not follow the criterion of having an impact factor equal to or greater than 4. Conclusion: There appears to be a relationship between the increase in pesticide use, particularly Glyphosate, and the rise in Alzheimer's disease prevalence.

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Section: Ad and Pesticidesmentioning

confidence: 99%

The Indiscriminate Use of Pesticides could Increase the Prevalence of Alzheimer's Disease? A Systematic Review

Trevisan,

Cristina-Pereira,

Santos

et al. 2024

Int. Neuropsy. Dis. J.

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Growth factors and their receptors

Lazaldin

Lambuk

Ahmad

et al. 2023

Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders

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A review of literature on Compound 21-loaded gelatin nanoparticle: a promising nose-to-brain therapy for multi-infarct dementia

Liyis

Sutedja

Kesuma

et al. 2023

Egypt J Neurol Psychiatry Neurosurg

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Multi-infarct dementia (MID) is described as a chronic progressive decline in cortical cognitive function due to the occurrence of multiple infarcts in the cerebral vascularization throughout the gray and white matter. Current therapies of MID mostly focus only on slowing down MID progression and symptomatic medications. A novel therapy which is able to provide both preventive and curative properties for MID is of high interest. The purpose of this review is to identify the potential of Compound 21 (C21) gelatin nanoparticle through the nose-to-brain route as therapy for MID. C21, an angiotensin II type 2 receptor (AT2R) agonist, has shown to reduce the size of cerebral infarct in rodent models, resulting in the preservation and improvement of overall cognitive function and prevention of secondary neurodegenerative effects. It is also shown that C21 decreases neuronal apoptosis, improves damaged axons, and encourage synapse development. The challenge remains in preventing systemic AT2R activation and increasing its low oral bioavailability which can be overcome through nose-to-brain administration of C21. Nose-to-brain drug delivery of C21 significantly increases drug efficiency and limits C21 exposure in order to specifically target the multiple infarcts located in the cerebral cortex. Adhering C21 onto gelatin nanoparticles may enable longer contact time with the olfactory and the trigeminal nerve endings, increasing the potency of C21. In summary, treatment of C21 gelatin nanoparticle through nose-to-brain delivery shows high potential as therapy for vascular dementia. However, clinical trials must be further studied in order to test the safety and efficacy of C21.

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Potential role of recombinant growth differentiation factor 11 in Alzheimer’s disease treatment

Cited by 4 publications

References 56 publications

The Indiscriminate Use of Pesticides could Increase the Prevalence of Alzheimer's Disease? A Systematic Review

The Indiscriminate Use of Pesticides could Increase the Prevalence of Alzheimer's Disease? A Systematic Review

Growth factors and their receptors

A review of literature on Compound 21-loaded gelatin nanoparticle: a promising nose-to-brain therapy for multi-infarct dementia

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