Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction

Song, Qixiang; Sun, Yi; Deng, Kangli; Mei, Jin-Yi; Chermansky, Christopher; Damaser, Margot S.

doi:10.1038/s41585-022-00621-1

Cited by 21 publications

(19 citation statements)

References 219 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, ALM intervention greatly recovered the levels of TG, T‐CHO, and LDL‐C and masterly augmented the level of HDL‐C, in which ALM acted a more effective role in controlling HDL‐C than ANC. Aside from dyslipidemia, tissue damage regarding hyperglycemia is also thought to be associated with oxidative stress (Song et al., 2022). As shown in Table 1, connected to dyslipidemia, plasma SOD level was slightly descended and MDA level performed a sharp increase after HFHFD treatment, indicating the existent oxidative stress.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Microencapsulation of anthocyanins extracted from black soybean peels by whey protein/fructo‐oligosaccharide contributes to improved stability, bioavailability, and ability to regulate glycolipid metabolism

Zhang,

Li,

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

Black soybean peels (BSPs) are rich in anthocyanins (ANCs), a naturally active substance added to manufactured foods. However, the instability of the ANC structure limits its application in the food industry. In the present study, an efficient and simple microencapsulation method to improve the stability of ANC was successfully established. BSP ANCs were encapsulated in a microencapsulated complex with fructo‐oligosaccharide (FOS) and whey protein (WP) associated with a high encapsulation rate (65.41%) and drug‐loading capacity (6.13%). The particle size and polydispersity index of anthocyanin‐loaded microencapsulation (ALM) were 4.648 ± 0.350 µm and 0.405 ± 0.107, respectively. The ANC stability test showed that ALM performed enhanced thermostability, pH stability, storage stability, and light stability. Meanwhile, in vitro release experiments indicated that ALM dramatically delayed the contact time of ANC with the environment and reduced the degradation. Moreover, animal experiments demonstrated that ALM better improved blood glucose homeostasis and lipid homeostasis in high‐fat‐ and high‐fructose‐treated mice and reduced liver lipid accumulation and damage. Additionally, the better in vivo bioactivity could be attributed to the extended bioavailability that was proved by a pharmacokinetics test. These results suggested that the microencapsulation employed WP‐FOS complexes as the wall materials are of great potential to improve the stability and health‐promoting properties of ANC, providing a promising solution as dietary supplementation.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Aside from dyslipidemia, tissue damage regarding hyperglycemia is also thought to be associated with oxidative stress (Song et al, 2022).…”

Section: Alm Ameliorated High-fat-and High-fructose Diet-induced Gluc...mentioning

confidence: 99%

Microencapsulation of anthocyanins extracted from black soybean peels by whey protein/fructo‐oligosaccharide contributes to improved stability, bioavailability, and ability to regulate glycolipid metabolism

Zhang,

Li,

et al. 2024

Food Frontiers

View full text Add to dashboard Cite

show abstract

“…Oxidative stress also causes inflammatory immune responses, enhancing ROS production and aggravating the oxidative stress response 32 . The oxidative stress response in diabetic patients can lead to changes in the morphology and function of the urothelium, leading to the development of DBD 34 . Neutrophils is a type of phagocytic immune cells, an indicator of response to oxidative stress 35 .…”

Section: Discussionmentioning

confidence: 99%

“…function of the urothelium, leading to the development of DBD. 34 Neutrophils is a type of phagocytic immune cells, an indicator of response to oxidative stress. 35 This study found that elevated ANC was an influencing factor in the occurrence of DBD.…”

Section: Aucmentioning

confidence: 99%

Predictive value of risk factors for bladder dysfunction in Chinese patients with type 2 diabetes mellitus: A case‐control study

Wang,

Liang

et al. 2023

Neurourology and Urodynamics

View full text Add to dashboard Cite

ObjectiveTo analyze risk factors associated with bladder dysfunction in patients with type 2 diabetes mellitus (T2DM) and to construct a prediction model for early prediction of diabetic bladder dysfunction (DBD).MethodsWe included hospitalized patients with T2DM from the endocrinology department of Shenzhen Hospital, Southern Medical University, Shenzhen, China, from January 2019 to 2022. Factors associated with DBD in bivariate analysis with a p < 0.05 were included in a multivariate logistic regression analysis. Multivariate logistic regression analysis was used to determine independent risk factors and to construct a prediction model. The prediction model was presented as the model formula. The receiver operating characteristic (ROC) curve was used to evaluate the predictive value of the above risk factors and the prediction model for DBD. The model was internally verified by Boostrap resampling 1000 times.ResultsTwo hundred and eleven patients were included in this study, and they were divided into the DBD group (n = 101) and the non‐DBD group (n = 110). Eight variables showed significant significance in the bivariate analysis, including age, diabetic peripheral neuropathy (DPN), glycated hemoglobin (HbA1c), urinary microalbumin (mALB), red blood cell count (RBC), white blood cell count (WBC), absolute neutrophil count (ANC), percentage of monocyte (Mono%). Furthermore, multivariate logistic regression analysis revealed that age (OR [95% CI]: 1.077 [1.042−1.112]), p < 0.001; DPN (OR [95% CI]: 2.373 [1.013−5.561]), p = 0.047; HbA1c (OR [95% CI]: 1.170 [1.029−1.330]), p = 0.017 and ANC (OR [95% CI]: 1.234 [1.059−1.438]), p = 0.007 were independent risk factors for the DBD. The prediction model formula was Logit (p) = −6.611 + 0.074 age + 0.864 DPN + 0.157 HbA 1 c + 0.078 ANC. The area under the ROC curve (AUC) for the four risk factors were 0.676, 0.582, 0.618, and 0.674, respectively. The prediction model predicted DBD with higher accuracy than the individual risk factors, AUC = 0.817 (95% CI: 0.757−0.877), and the sensitivity and specificity were 88.1% and 50.0%, respectively. The model internal validation results showed that the AUC = 0.804 (95% CI: 0.707−0.901), and the calibration curve is close to the ideal diagonal line.ConclusionsAge, DPN, HbA1c, and ANC were risk factors for DBD. The prediction model constructed based on the four risk factors had a good predictive value for predicting the occurrence of DBD.

show abstract

“…15,16 Diabetes is a group of metabolic diseases characterized by persistent hyperglycemia majorly caused by insulin resistance. In the early stage of DBD, the pathophysiology of OAB syndrome may be elicited from several aspects of metabolic disturbances, such as insulin resistance in the bladder mucosa, 17 or excessive metabolites from the tricarboxylic acid cycle (e.g., succinate overproduction), 18,19 and dysregulated oxidative stress, 20 which may trigger the OAB syndrome of diabetic patients through extensive dysfunction in the urothelium, bladder detrusor muscle, and afferent and efferent nerves. 21 In the present study, OAB-wet seems to be a dominant OAB category and appears to be significantly bothersome among diabetic participants.…”

Section: Discussionmentioning

confidence: 99%

The impact of diabetes on overactive bladder presentations and associations with health-seeking behavior in China, South Korea, and Taiwan: Results from a cross-sectional, population-based study

Lee,

Chow,

Hsu

et al. 2023

Journal of the Chinese Medical Association

View full text Add to dashboard Cite

Background: This study aimed to explore the impact of diabetes on overactive bladder (OAB) presentations and related predictors of healthcare-seeking behavior among adults aged ≥ 40 years in China, Taiwan, and South Korea. Methods: A internet-based survey was conducted to assess the prevalence of diabetes, OAB presentations, and self-perceived urinary symptoms by a multi-national sample of 8284 individuals who completed the survey between June 2, 2015 and July 31, 2015. Independent associations with health-seeking behavior for urinary symptoms was estimated with odds ratio (OR) with 95% confidence interval (95%CI) using multivariate logistic regression. Results: Diabetes was reported in 13.6% participants and OAB was 20.8%. Diabetic participants were older than non-diabetic participants in both sexes. Participants with diabetes reported a higher rate of OAB (43.1%) and increased bothersome symptoms associated with OAB than those without diabetes. Participants with diabetes (OR, 3.07 [2.39-3.96]], urgent incontinence (OR, 2.38 [1.86-3.03]), frequency (OR, 1.86 [1.45-2.38]), and nocturia (OR, 1.14 [1.05-1.24]) were associated with healthcare-seeking behavior. Conclusion: The proportion of diabetic participants with OAB was 2.5-fold higher than those without diabetes. Diabetes, urinary frequency, nocturia, and urgent incontinence are predictors of medical treatment-seeking behavior, but the key symptom of OAB-urgency is not a predictor of treatment-seeking behavior. It is important for clinicians to recognize the interplay between diabetes and OAB and to early identify various bothersome urinary symptoms for better health outcomes in daily practice.

show abstract

Potential role of oxidative stress in the pathogenesis of diabetic bladder dysfunction

Cited by 21 publications

References 219 publications

Microencapsulation of anthocyanins extracted from black soybean peels by whey protein/fructo‐oligosaccharide contributes to improved stability, bioavailability, and ability to regulate glycolipid metabolism

Microencapsulation of anthocyanins extracted from black soybean peels by whey protein/fructo‐oligosaccharide contributes to improved stability, bioavailability, and ability to regulate glycolipid metabolism

Predictive value of risk factors for bladder dysfunction in Chinese patients with type 2 diabetes mellitus: A case‐control study

The impact of diabetes on overactive bladder presentations and associations with health-seeking behavior in China, South Korea, and Taiwan: Results from a cross-sectional, population-based study

Contact Info

Product

Resources

About