Potential role of N-benzylcinnamide in inducing neuronal differentiation from human amniotic fluid mesenchymal stem cells

Thangnipon, Wipawan; Puangmalai, Nicha; Suwanna, Nirut; Soi-ampornkul, Rungtip; Phonchai, Ruchee; Kotchabhakdi, Naiphinich; Mukda, Sujira; Phermthai, Tatsanee; Julavijitphong, Suphakde; Tuchinda, Patoomratana; Nobsathian, Saksit

doi:10.1016/j.neulet.2015.10.050

Cited by 9 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When we treated AFS cells with retinoic acid to induce neural differentiation, we observed an increase in p53 protein levels [112] which is consistent with the studies of Thangnipon et al and Gasiūnienė et al Thangnipon and his crew observed increased p53 levels when they induced neuronal differentiation of AFS cells with a combination of N-benzylcinnamide and bone morphogenetic protein (BMP)-9 [116] whereas Gasiūnienė and colleagues observed an increase in p53 mRNA and protein levels upon cardiomyogenic differentiation in AFS cells using DNMT methyltransferases and p53 inhibitors [117]. We could furthermore show that p53 is an important determinant for the DNA damage response of AFS cells.…”

Section: P53 In Amniotic Fluid Stem Cellssupporting

confidence: 83%

Amniotic Fluid Cells, Stem Cells, and p53: Can We Stereotype p53 Functions?

Rodrigues

Blattner

Stuppia

2019

IJMS

View full text Add to dashboard Cite

In recent years, great interest has been devoted to finding alternative sources for human stem cells which can be easily isolated, ideally without raising ethical objections. These stem cells should furthermore have a high proliferation rate and the ability to differentiate into all three germ layers. Amniotic fluid, ordinarily discarded as medical waste, is potentially such a novel source of stem cells, and these amniotic fluid derived stem cells are currently gaining a lot of attention. However, further information will be required about the properties of these cells before they can be used for therapeutic purposes. For example, the risk of tumor formation after cell transplantation needs to be explored. The tumor suppressor protein p53, well known for its activity in controlling Cell Prolif.eration and cell death in differentiated cells, has more recently been found to be also active in amniotic fluid stem cells. In this review, we summarize the major findings about human amniotic fluid stem cells since their discovery, followed by a brief overview of the important role played by p53 in embryonic and adult stem cells. In addition, we explore what is known about p53 in amniotic fluid stem cells to date, and emphasize the need to investigate its role, particularly in the context of cell tumorigenicity.

show abstract

Section: P53 In Amniotic Fluid Stem Cellssupporting

confidence: 83%

Amniotic Fluid Cells, Stem Cells, and p53: Can We Stereotype p53 Functions?

Rodrigues

Blattner

Stuppia

2019

IJMS

View full text Add to dashboard Cite

show abstract

“…Antioxidant treatment abolishes the effects of BMP7 on dendrite formation, data that demonstrates the importance of ROS in this phenomenon [81]. Additionally, BMP9 induces and maintains the neuronal cholinergic phenotypes in the central nervous system by inducing gene expression of choline acetyltransferase and vesicular acetylcholine transporter [104]. Interestingly, BMP9 levels and its bioavailability are reduced by redox-dependent proteolysis [105].…”

Section: Bmps and Ros In Cell Specificationmentioning

confidence: 99%

Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology

et al. 2019

View full text Add to dashboard Cite

The integration of cell extrinsic and intrinsic signals is required to maintain appropriate cell physiology and homeostasis. Bone morphogenetic proteins (BMPs) are cytokines that belong to the transforming growth factor-β (TGF-β) superfamily, which play a key role in embryogenesis, organogenesis and regulation of whole-body homeostasis. BMPs interact with membrane receptors that transduce information to the nucleus through SMAD-dependent and independent pathways, including PI3K-AKT and MAPKs. Reactive oxygen species (ROS) are intracellular molecules derived from the partial reduction of oxygen. ROS are highly reactive and govern cellular processes by their capacity to regulate signaling pathways (e.g., NF-κB, MAPKs, KEAP1-NRF2 and PI3K-AKT). Emerging evidence indicates that BMPs and ROS interplay in a number of ways. BMPs stimulate ROS production by inducing NOX expression, while ROS regulate the expression of several BMPs. Moreover, BMPs and ROS influence common signaling pathways, including PI3K/AKT and MAPK. Additionally, dysregulation of BMPs and ROS occurs in several pathologies, including vascular and musculoskeletal diseases, obesity, diabetes and kidney injury. Here, we review the current knowledge on the integration between BMP and ROS signals and its potential applications in the development of new therapeutic strategies.

show abstract

Amniotic fluid cells: current progress and emerging challenges in renal regeneration

2017

View full text Add to dashboard Cite

Amniotic fluid (AF) contains a heterogeneous population of cells that have been identified to possess pluripotent and progenitor-like characteristics. These cells have been applied in various regenerative medicine applications ranging from in vitro cell differentiation to tissue engineering to cellular therapies for different organs including the heart, the liver, the lung, and the kidneys. In this review, we examine the different methodologies used for the derivation of amniotic fluid stem cells and renal progenitors, and their application in renal repair and regeneration. Moreover, we discuss the recent achievements and newly emerging challenges in our understanding of their biology, their immunoregulatory characteristics, and their paracrine-mediated therapeutic potential for the treatment of acute and chronic kidney diseases.

show abstract

Potential role of N-benzylcinnamide in inducing neuronal differentiation from human amniotic fluid mesenchymal stem cells

Cited by 9 publications

References 20 publications

Amniotic Fluid Cells, Stem Cells, and p53: Can We Stereotype p53 Functions?

Amniotic Fluid Cells, Stem Cells, and p53: Can We Stereotype p53 Functions?

Interplay between BMPs and Reactive Oxygen Species in Cell Signaling and Pathology

Amniotic fluid cells: current progress and emerging challenges in renal regeneration

Contact Info

Product

Resources

About