“…Further support for the concept that reduced neutrophil numbers or function increase the periodontal susceptibility of patients comes from the studies of diabetics (17, 91), reduced chemotaxis in Down's syndrome (60) and neutrophil dysfunction in people with Papillon-Lefevre syndrome (156). Van Dyke et al (154) found that people with inflammatory bowel disease, including those with Crohn's disease and ulcerative colitis, had defects in neutrophil chemotaxis. They found that people with ulcerative colitis had reduced cell associated chemotaxis as compared with control subjects, whereas in those with Crohn's disease, the neutrophil cell-associated chemotactic response was not significantly different.…”