Potential Role of lncRNA H19 as a Cancer Biomarker in Human Cancers Detection and Diagnosis: A Pooled Analysis Based on 1585 Subjects

Abstract

Long noncoding RNAs (lncRNAs) have been reported to serve as diagnostic and prognostic biomarkers of cancers, which play vital roles in tumorigenesis and tumor progression. Several studies have been performed to explore diagnostic value of lncRNA H19 in cancer detection and diagnosis. However, there are still inconsistent results in diagnostic accuracy and reliability in individual studies. Therefore, the present study was performed to summarize the overall diagnostic performance of lncRNA H19 in cancer detection and diagnosis. A total of eight studies with 770 cases and 815 controls were included in this pooled analysis. The pooled diagnostic results were as follows: sensitivity, 0.69 (95%CI=0.62-0.76), specificity, 0.79 (95% CI=0.70-0.86), positive likelihood ratio (PLR), 3.31 (95%CI=2.29-4.78), negative likelihood (NLR), 0.39 (95%CI=0.31-0.49), diagnostic odds ratio (DOR), 8.53 (95%CI=4.99-14.60), and area under the curve (AUC), 0.79 (95%CI=0.76-0.83). Deeks’ funnel plot asymmetry test (P=0.13) suggested no potential publication bias. Our results indicated that lncRNA H19 had a relatively moderate accuracy in cancer detection and diagnosis. Further comprehensive prospective studies with large sample sizes are urgently required to validate our findings.

Silencing of Long Noncoding RNA LINC00324 Interacts with MicroRNA-3200-5p to Attenuate the Tumorigenesis of Gastric Cancer via Regulating BCAT1

“…Abnormal expression of lncRNAs is related to the tumorigenesis of GC [20,21]. Some lncRNAs, such as Sox2ot [22], ANRIL [23], and H19 [24], are upregulated in patients with GC. In this study, the expression of LINC00324 in tumor tissues was higher than that in adjacent normal tissues in GC patients.…”

The relationship between H19 and parameters of ovarian reserve

“…We also report a correlation between serum H19 and AMH, a marker of follicular response during IVF 23 . Circulating H19 has been explored as a diagnostic and prognostic biomarker for other conditions including coronary artery disease [43], multiple myeloma [44], and cancers including bladder and gastric cancer [22,40,41,45,46]. In the reproductive tract, circulating H19 is higher in women with polycystic ovary syndrome (PCOS) compared to controls [47], and H19 has been identified as a potential diagnostic and prognostic marker for epithelial ovarian [48] and cervical cancer [49].…”

Blocking lncRNA H19-miR-19a-Id2 axis attenuates hypoxia/ischemia induced neuronal injury

“…These results indicated H19 level could be a diagnostic and prognostic biomarker for ischemic stroke. However, circulating H19 levels may be a non-specific biomarker, since elevated circulating H19 levels have been implicated in diverse oncological conditions [9–12, 22–26]. Known oncological etiologies would have to be ruled out prior to designating H19 level as a more specific biomarker for cerebra ischemia.…”